The gender-geneticassessment of frequencyoccurrence of diastolicdysfunction and types of hypertonicremodeling in patientswith controlledand uncontrolledarterial hypertension


In this investigation there was revealed the interconnection of the hypertonic remodeling
type and the difficulty of breaking diastolic function from genotypes characterizing the flow of
arterial hypertension. 76 persons have been investigated: 42 persons with controlled arterial
hypertension, 34 persons with uncontrolled arterial hypertension. All patients were compared
by age and sex. The investigation of echocardiography by using the apparatus Medison Sonoace
8000 was conducted. The molecular genetic investigation with determining genotypes of
polymorphic genes ACE, AGT2R1, eNos was also conducted for all patients. So, the connection
of diastolic dysfunction of the heart at women with uncontrolled arterial hypertension is
associated with concentric hypertrophy of the left ventricle. The difficulty of the diastolic
function and the prognosticly unfavourable type of remodeling heart are associated with
genotypes: ACE - II, AGT2R1 - AG, eNos - ab.


  1. Оганов Р.Г. Профилактика сердечно-сосудистых заболеваний: возможности практического здравоохранения // Кардиоваскулярная терапия и профилактика.- 2002.- № 1.- С. 5-9.
  2. Kenchaiah S., Pfeffer M. Cardiac remodeling in systemic hypertension // Med Clin North Am. -2004. - Vol. 88 (1). - P. 115-130.
  3. Скибицкий В.В., Медведева Ю.Н., Шухардина Е.Л. Взаимосвязь вариабельности артериального давления и ремоделирования левого желудочка при метаболическом синдроме у женщин в хирургическом климаксе // Артериальная гипертензия. - 2006. - № 12 (Приложение). - С. 75-76.
  4. Жмайлова C.B., Рубанова М.П., Вебер В.Р. Эволюция типов гемодинамики и особенности ремоделирования сердца у женщин с артериальной гипертензией 2 степени // Некоронарогенные заболевания миокарда: диагностика, лечение, проблемы профилактики: Материалы Всероссийской научно-практической конференции. - СПб., 2006. - С. 145.
  5. Deng, A. Y. Genetic basis of polygenic hypertension / A. Y. Deng // Human molecular genetics. - 2007. - Vol. 16, R 2. - P. R195-R202.
  6. Soubrier, F. Nitric Oxide Synthase Genes: Candidate Genes Among Many Others / F. Soubrier // Hypertension. - 1999. - Vol. 33, № 4. - P. 924-926.



Abstract - 39


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Copyright (c) 2012 Mel'nikova M.A., Olezov N.V., Mel'nikov A.A., Melnikova M.A., Olezov N.V., Melnikov A.A.

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