The spectral opticaltomography study of the layers of the retina in patients with multiple sclerosis

Abstract


In our research work the spectral optical tomography Spectralis OCT BluePeak study of the layers of the retina 39 (77 eyes) patients with multiple sclerosis and 12 (24 eyes) comparatively healthy patients with myopic refraction was carried out. For visualization of the fundus it was clearly identified 8 out of 10 layers of the retina. With the help of the developed method the apparent thickness of each layer with an accuracy of ± 5 microns was calculated. It was shown that the patients with multiple sclerosis in addition to general thinning of the first layer of nerve fibers in the retina peripapillary area had statistically significant thinning of the layer of the retina in ganglion layer paramakula area. The average ganglion layer of the retina in the patients with multiple sclerosis ranged 85,75±1,68 µm, whereas in the control group of patients with myopic refraction of the layer thickness varied 97,92±2,26 µm (p<0,01). Layered evaluation of the retina showed characteristic deficits ganglion layer of the retina in patients with multiple sclerosis, which may be a specific marker of multiple sclerosis.

About the authors

E V Sineok

E V Sineok

References

  1. Гусева Е. И. Рассеянный склероз и другие демиелинизирующие заболевания / Е. И. Гусева, И.А. Завалишин, А.Н. Бойко // М.: Миклош. 2004. - 540 с.
  2. Гусева, М.Р. Результаты клинико-иммуногенетического обследования при оптических невритах у детей с достоверным рассеянным склерозом / М.Р. Гусева, С.Ю. Бойко, И. О. Маслова // Неврологический журнал. 1999. - № 5. - C.10-15
  3. Шмидт, Т.Е. Рассеянный склероз /Т.Е. Шмидт, Н.Н. Яхно // М.: Медицина. 2003. - 160 c.
  4. Burkholder, B.M. Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis / B.M. Burkholder, B. Osborne, M.J. Loguidice et. al. // Arch Neurol. - 2009. - Vol. 66. - N.11. - P.1366-1372.
  5. Cettomai, D. Reproducibility of Optical Coherence Tomography in Multiple Sclerosis / D. Cettomai, M. Pulicken, E. Gordon-Lipkin et. al. // Arch Neurol. - 2008. - Vol. 65. - N.9. - P. 1218-1222.
  6. Fu, Y. New imaging techniques in the diagnosis of multiple sclerosis / Y. Fu, T. M. Talavage, Ji-Xin Cheng et al. // Expert Opin. Med. Diagn. - 2008. - Vol. 2. - №9. - P. 1055-1065.
  7. Hougaard, J. L. Evaluation of Heredity as a Determinant of Retinal Nerve Fiber Layer Thickness as Measured by Optical Coherence Tomography / J. L. Hougaard, L. Kessel, B. Sander, et al. // Investigative Ophthalmology and Visual Science. - 2003. - Vol. 44. - P. 3011- 3016.
  8. Koh, V.T. Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography / V.T. Koh, Y.C. Tham, C.Y. Cheung et al.// Invest Ophthalmol. Vis. Sci. - 2012. - Vol. 53. - N9. - P. 5853-5859.
  9. Parisi, V. Correlation between Morphological and Functional Retinal Impairment in Multiple Sclerosis Patients / V. Parisi, G. Manni, M. Spadaro, et al. // Investigative Ophthalmology and Visual Science. - 1999. - Vol. 40. - P. 2520-2527
  10. Pinilla, I. Comparison of Retinal Nerve Fiber Layer Thickness Measurements in Healthy Subjects Using Fourier and Time Domain Optical Coherence Tomography/ I. Pinilla, E. Garcia-Martin, M. Idoipe et al.// J Ophthalmol. - 2012. -Vol. 5. - N3. -P. 401-405.
  11. Ratchford, J.N., Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies / J.N. Ratchford, M.E. Quigg, A. Conger et. al. // Neurology. - 2009. - Vol. 73. - N. 4. - P. 302-308.
  12. Gundogan, F. C. Demirkaya S. Sobaci G. Is Optical Coherence Tomography Really a New Biomarker Candidate in Multiple Sclerosis?-A Structural and Functional Evaluation / F. C. a, S. Demirkaya G. Sobaci // Investigative Ophthalmology and Visual Science. - 2007 - Vol. 48. - P. 5773-5781.
  13. Cettomai, D. Reproducibility of Optical Coherence Tomography in Multiple Sclerosis / D. Cettomai, M. Pulicken, E. Gordon-Lipkin et. al. // Arch Neurol. - 2008. - Vol. 65. - N.9. - P. 1218-1222.
  14. Fu, Y. New imaging techniques in the diagnosis of multiple sclerosis / Y. Fu, T. M. Talavage, Ji-Xin Cheng et al. // Expert Opin. Med. Diagn. - 2008. - Vol. 2. - №9. - P. 1055-1065.
  15. Hougaard, J. L. Evaluation of Heredity as a Determinant of Retinal Nerve Fiber Layer Thickness as Measured by Optical Coherence Tomography / J. L. Hougaard, L. Kessel, B. Sander, et al. // Investigative Ophthalmology and Visual Science. - 2003. - Vol. 44. - P. 3011- 3016.
  16. Koh, V.T. Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography / V.T. Koh, Y.C. Tham, C.Y. Cheung et al.// Invest Ophthalmol. Vis. Sci. - 2012. - Vol. 53. - N9. - P. 5853-5859.4
  17. Parisi, V. Correlation between Morphological and Functional Retinal Impairment in Multiple Sclerosis Patients / V. Parisi, G. Manni, M. Spadaro, et al. // Investigative Ophthalmology and Visual Science. - 1999. - Vol. 40. - P. 2520-2527.
  18. Pinilla, I. Comparison of Retinal Nerve Fiber Layer Thickness Measurements in Healthy Subjects Using Fourier and Time Domain Optical Coherence Tomography/ I. Pinilla, E. Garcia-Martin, M. Idoipe et al.// J Ophthalmol. - 2012. -Vol. 5. - N3. -P. 401-405.
  19. Ratchford, J.N., Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies / J.N. Ratchford, M.E. Quigg, A. Conger et. al. // Neurology. - 2009. - Vol. 73. - N. 4. - P. 302-308.
  20. Гусева, Е. И. Рассеянный склероз и другие демиелинизирующие заболевания / Е. И. Гусева, И.А. Завалишин, А.Н. Бойко // М.: Миклош. 2004. - 540С
  21. Гусева, М.Р. Результаты клинико-иммуногенетического обследования при оптических невритах у детей с достоверным рассеянным склерозом / М.Р. Гусева, С.Ю. Бойко, И. О. Маслова // Неврологический журнал. 1999. - № 5. - с.10-15
  22. Шмидт, Т.Е. Рассеянный склероз /Т.Е. Шмидт, Н.Н. Яхно // М.: Медицина. 2003. - 160 c.
  23. Koh, V.T. Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography / V.T. Koh, Y.C. Tham, C.Y. Cheung et al.// Invest Ophthalmol. Vis. Sci. - 2012. - Vol. 53. - N9. - P. 5853-5859.
  24. Burkholder, B.M. Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis / B.M. Burkholder, B. Osborne, M.J. Loguidice et. al. // Arch Neurol. - 2009. - Vol. 66. - N.11. - P.1366-1372.
  25. Cettomai, D. Reproducibility of Optical Coherence Tomography in Multiple Sclerosis / D. Cettomai, M. Pulicken, E. Gordon-Lipkin et. al. // Arch Neurol. - 2008. - Vol. 65. - N.9. - P. 1218-1222.
  26. Fu, Y. New imaging techniques in the diagnosis of multiple sclerosis / Y. Fu, T. M. Talavage, Ji-Xin Cheng et al. // Expert Opin. Med. Diagn. - 2008. - Vol. 2. - №9. - P. 1055-1065.
  27. Gundogan, F. C. Demirkaya S. Sobaci G. Is Optical Coherence Tomography Really a New Biomarker Candidate in Multiple Sclerosis?-A Structural and Functional Evaluation / F. C. Gundogan, S. Demirkaya G. Sobaci // Investigative Ophthalmology and Visual Science. - 2007 - Vol. 48. - P. 5773-5781.

Statistics

Views

Abstract - 33

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions

Refbacks

  • There are currently no refbacks.

Copyright (c) 1970 Sineok E.V., Sineok E.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies