The spectral opticaltomography study of the layers of the retina in patients with multiple sclerosis



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Abstract

In our research work the spectral optical tomography Spectralis OCT BluePeak study of the layers of the retina 39 (77 eyes) patients with multiple sclerosis and 12 (24 eyes) comparatively healthy patients with myopic refraction was carried out. For visualization of the fundus it was clearly identified 8 out of 10 layers of the retina. With the help of the developed method the apparent thickness of each layer with an accuracy of ± 5 microns was calculated. It was shown that the patients with multiple sclerosis in addition to general thinning of the first layer of nerve fibers in the retina peripapillary area had statistically significant thinning of the layer of the retina in ganglion layer paramakula area. The average ganglion layer of the retina in the patients with multiple sclerosis ranged 85,75±1,68 µm, whereas in the control group of patients with myopic refraction of the layer thickness varied 97,92±2,26 µm (p<0,01). Layered evaluation of the retina showed characteristic deficits ganglion layer of the retina in patients with multiple sclerosis, which may be a specific marker of multiple sclerosis.

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E V Sineok

E V Sineok

References

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  22. Шмидт, Т.Е. Рассеянный склероз /Т.Е. Шмидт, Н.Н. Яхно // М.: Медицина. 2003. - 160 c.
  23. Koh, V.T. Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography / V.T. Koh, Y.C. Tham, C.Y. Cheung et al.// Invest Ophthalmol. Vis. Sci. - 2012. - Vol. 53. - N9. - P. 5853-5859.
  24. Burkholder, B.M. Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis / B.M. Burkholder, B. Osborne, M.J. Loguidice et. al. // Arch Neurol. - 2009. - Vol. 66. - N.11. - P.1366-1372.
  25. Cettomai, D. Reproducibility of Optical Coherence Tomography in Multiple Sclerosis / D. Cettomai, M. Pulicken, E. Gordon-Lipkin et. al. // Arch Neurol. - 2008. - Vol. 65. - N.9. - P. 1218-1222.
  26. Fu, Y. New imaging techniques in the diagnosis of multiple sclerosis / Y. Fu, T. M. Talavage, Ji-Xin Cheng et al. // Expert Opin. Med. Diagn. - 2008. - Vol. 2. - №9. - P. 1055-1065.
  27. Gundogan, F. C. Demirkaya S. Sobaci G. Is Optical Coherence Tomography Really a New Biomarker Candidate in Multiple Sclerosis?-A Structural and Functional Evaluation / F. C. Gundogan, S. Demirkaya G. Sobaci // Investigative Ophthalmology and Visual Science. - 2007 - Vol. 48. - P. 5773-5781.

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Copyright (c) 1970 Sineok E.V., Sineok E.V.

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