Leptin and antiinflammatory factor relationship in patients with myocardial infarction



Cite item

Full Text

Abstract

Lack of information about the nature of changes in leptin and its relationship with anti-inflammatory factors in the development of acute coronary events has determined the feasibility of the study. The study included patients with myocardial infarction with and without type 2 diabetes. Identified giperleptinemiya and elevated concentrations of antiinflammatory factors such as CRP and IL-6, as well as their relationship with markers of myocardial necrosis (CK-MB) and leptin can be considered as one of the most important parts of the inflammatory response in myocardial infarction, not only in patients with diabetic history, but also in patients without this comorbidity. The study may form the basis for new diagnostic and therapeutic tactics correction of metabolic abnormalities in patients with acute coronary vascular disease.

About the authors

E V Belik

E V Belik

References

  1. Hansson G. K. Inflammation, Atherosclerosis, and Coronary Artery Disease // Engl J Med. - 2005. - Vol. 352. - P. 1685-1695.
  2. Rydén L, Standl E, Bartnik M, Van den Berghe G. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD) // Eur Heart J. - 2007. - Vol. 28 (1). - P. 88-136.
  3. Дедов И.И, Мельниченко Г.А, Фадеев В.Ф. Эндокринология. М.: ГЭОТАР-Медиа, 2007. - 432 с.
  4. Fujimaki S., Kanda T., Fujita K., Tamura J., Kobayashi I. The significance of measuring plasma leptin in acute myocardial infarction // J Int Med Res. - 2001. - Vol. 29(2). - P. 13-108.
  5. Yang R., Lili A. Barouch leptin signaling and obesity. Cardiovascular consequences // Circulation Research. - 2007. - Vol. 101. - P. 545-559.
  6. Fujimaki S., Kanda T., Fujita K., Tamura J., Kobayashi I. The significance of measuring plasma leptin in acute myocardial infarction // J Int Med Res. - 2001. - Vol. 29(2). - P. 13-108.
  7. Purdham D. , Zou M., Rajapurohitam V., Karmazyn M. Rat heart is asite of leptin production and action // Am J Physiol Heart Circ Physiol. - 2004. - Vol. 287. - P. 2877-2884.
  8. Matsui H., Motooka M., Koike H., Inoue M., Iwasaki T., Suzuki T., Kurabayashi M., Yokoyama T. Ischemia/reperfusion in rat heart induces leptin and leptin receptor gene expression // Life Sci. - 2007. - Vol. 80. - P. 672-680.
  9. Hansson G. K. Inflammation, Atherosclerosis, and Coronary Artery Disease // Engl J Med. - 2005. - Vol. 352. - P. 1685-1695.
  10. Lord G., Matarese G., Howard J. et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression // Nature. - 1998. - Vol. 394. - P. 897-901.
  11. Barret T., Hennan J., Marks R. et al. C-reactive-protein-associated increase in myocardial infarct size after ischemia/reperfusion // The J. of Pharmacology and experimental therapeutics. - 2002. - Vol. 303. - №. 3. - P.1007-1013.
  12. Fujimaki S., Kanda T., Fujita K., Tamura J., Kobayashi I. The significance of measuring plasma leptin in acute myocardial infarction // J Int Med Res. - 2001. - Vol. 29(2). - P. 13-108.
  13. Lord G., Matarese G., Howard J. et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression // Nature. - 1998. - Vol. 394. - P. 897-901.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 1970 Belik E.V., Belik E.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies