Parameters of lipid circulatory system in patients with myocardial infarction and one-, two-, three vascular impairment of coronary bed



Cite item

Full Text

Abstract

The steady growth of mortality from MI gives proof of searching of new markers of cardiovascular pathology development. It is known that the key role in the development of atherosclerosis dysfunction is played by oxidatively modified LDL and antibodies to them, generated on the background of oxidative stress. The lack of information about the participation of these markers in the development of myocardial infarction depending on the gravity of the impairment of coronary bed explains the rationale of this study. The patients with myocardial infarction with ST segment elevation with hemodynamically significant stenosis ≥ 75% of one, two, three or more of the coronary arteries were examined. The increase of concentration of oxLDL and antibodies to them on the background of increasing markers of lipid spectrum and indicators pro-/antioxidant systems, continuing and in the subacute period MI, may be a reflection of the gravity of the defeat of coronary bed, in connection with which significantly expand the possibilities of diagnostics of acute as well as recurrent coronary events in patients with myocardial infarction with ST segment elevation in conjunction with multivascular defeat.

About the authors

Yu A Dyleva

Yu A Diljeva

References

  1. Оганов Р.Г., Масленникова Г.Я. // Кардиоваскулярная терапия и профилактика - 2002. - №.3. - с.4-8.
  2. Sorjja P., Gersh B.J., Cox D.A. et al. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction. // Eur. Heart J. 2007. Vol. - 28. - P. 1709-1716.
  3. Parodi G., Memisha G., Valenti R. et al. Five year outcome after primary coronary intervention for acute ST elevation myocardial infarction: results from a single centre experience. // Heart. - 2005. - Vol. 91. - P. 1541-1544
  4. Климов, А.Н., Никульчева Н.Г. Обмен липидов и липопротеидов и его нарушения. - СПб., 2001.
  5. Yusuf S., Hawken S., azOunpuu S. et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries.// Lancet. - 2004. - Vol. 364. - Р. 937-952.
  6. Ansell B.J., Navab M., Hama S. et al. Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment. // Circulation <http://circ.ahajournals.org>. - 2003. - Vol. 108. - P. 2751-2756.
  7. Downs J.R., Clearfield M., Weis S., et al. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AF CAPS/TexCAPS. // JAMA. - 1998. Vol. 279/ - Р. 1615-1622.
  8. Castelli W.P., Garrison R.J.,Wilson P.W.F., Abbott R.D., Kalousdian S., Kannel W.B. Incidence of coronary heart disease and lipoprotein cholesterol levels. // JAMA. - 1986. - Vol. 256. - Р. 2835-2838.
  9. Khot U.N., Khot M.B., Bajzer C.T., et al. Prevalence of conventional risk factors in patients with coronary heart disease. // JAMA. - 2003. - Vol. 290. - P. 898-904.
  10. Naruko T., Veda M., Ehara S., Iton A. et al. Persistent high levels of plasma oxidized low-density lipoprotein after acute myocardial infarction predict stent restenosis. // Arteriosclerosis, Thrombosis, and Vascular Biology. - 2006. - Vol. 26. - P.877-883.
  11. Parodi G., Memisha G., Valenti R. et al. Five year outcome after primary coronary intervention for acute ST elevation myocardial infarction: results from a single centre experience. // Heart. - 2005. - Vol. 91. - P. 1541-1544.
  12. Климов, А.Н., Никульчева Н.Г. Обмен липидов и липопротеидов и его нарушения. - СПб., 2001.
  13. Khot U.N., Khot M.B., Bajzer C.T., et al. Prevalence of conventional risk factors in patients with coronary heart disease. // JAMA. - 2003. - Vol. 290. - P. 898-904.
  14. Barter P.J., Ballantyne C.M., Carmena R. et al. Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the Thirty-Person/Ten-Country Panel. // J. Intern. Med. - 2006. - Vol. 259. - P. 247-258.
  15. Walldius G., Jungner I., Holme I. et al. High apolipoprotein B, low apolipopro-tein Al, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study. // Lancet. - 2001. - Vol. 358. - Р. 2026-2033.
  16. Virella G., Lopes-Virella M. Lipoprotein Autoantibodies: Measurement and Significance. // Clinical and diagnostic laboratory immunology. - 2003. - Vol. 10(4). - Р. 499-505.
  17. Steinberg D. Low density lipoprotein oxidation and its pathological significance. // J. Biol Chem. - 1997. - Vol. 272. - Р. 20963-20966.
  18. Меньщикова Е.Б., Зенков Н.К., Ланкин В.С., Бондарь И.А., Труфакин В.А. Окислительный стресс: Патологические состояния и заболевания. - Новосибирск, 2008.
  19. Steinberg D. Low density lipoprotein oxidation and its pathological significance. // J. Biol Chem. - 1997. - Vol. 272. - Р. 20963-20966.
  20. Naruko T., Veda M., Ehara S., Iton A. et al. Persistent high levels of plasma oxidized low-density lipoprotein after acute myocardial infarction predict stent restenosis. // Arteriosclerosis, Thrombosis, and Vascular Biology. - 2006. - Vol. 26. - P.877-883.
  21. Virella G., Lopes-Virella M. Lipoprotein Autoantibodies: Measurement and Significance. // Clinical and diagnostic laboratory immunology. - 2003. - Vol. 10(4). - Р. 499-505.
  22. Erkkila A. T., Narvanen O., Lehto S. et. al. Autoantibodies against oxidized low-density lipoprotein and cardiolipin in patients with coronary heart disease. // Arterioscler. Thromb. Vasc. Biol. - 2000. - Vol. 20. - Р. 204-209.
  23. Naruko T., Veda M., Ehara S., Iton A. et al. Persistent high levels of plasma oxidized low-density lipoprotein after acute myocardial infarction predict stent restenosis. // Arteriosclerosis, Thrombosis, and Vascular Biology. - 2006. - Vol. 26. - P.877-883.
  24. Меньщикова Е.Б., Зенков Н.К., Ланкин В.С., Бондарь И.А., Труфакин В.А. Окислительный стресс: Патологические состояния и заболевания. - Новосибирск, 2008.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 1970 Dyleva Y.A., Diljeva Y.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies