Metabolites levelin blood and enzymes activity inthe liver at acute alcoholicintoxication in ratswith experimental diabetes

Abstract

On the model of acute alcoholic intoxication at a singl dose 4 g/kg in rats is shown that in 6 hours in blood the level of free fat acids, urea is increased. In 24 hours concentration of glucose, lactate and urea is increased, the level of free fat acids decreases. Activity of glutamatdehydrogenasa and tirosinaminotransferasa in liver at acute alcoholic intoxication increases. In the rats with experimental diabetes (15 day) in 6 hours after an injection of ethanol in blood the level of glucose, urea, triglycerols is increased, the concentration of free amino acids, lactate is lowered. In this condition in liver of experimental animals activity of glutamatdehydrogenasa decreases and tirosinaminotransferasa increases. In 24 hours in blood concentration of triglycerols is lowered very much, the level of urea remains increased.

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Copyright (c) 2012 Zharkova N.V., Stel'makh A.Y., Medvedeva N.B., Zharkova N.V., Stelmakh A.Y., Medvedeva N.B.

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