Aspirantskiy Vestnik PovolzhiyaAspirantskiy Vestnik Povolzhiya2072-23542410-3764Samara State Medical University2419110.17816/2075-2354.2018.18.137-144Research ArticlePROFESSIONAL RISK AND THE GROWTH FACTORS FGF2, VEGF IN PREDICTING OCCUPATIONAL LUNG DISEASESBudashD STeaching assistant, Department of professional Diseases and Clinical Pharmacology n.a. after honored scientist of the Russian Federation, Professor V.V. Kosarev, Samara State Medical University, Candidate of Medicinedashyyha15@yandex.ruBabanovS AHead of Department of Occupational Diseases and Clinical Pharmacology n.a. honored scientist of the Russian Federation, Professor V.V. Kosarev, Samara State Medical University, Doctor of Medicine, Professor.s.a.babanov@mail.ruSamara State Medical University15032018181-213714411032020Copyright © 2018, Budash D.S., Babanov S.A.2018The article is investigates occupational risk in workers with prolonged working experience who are exposed to industrial aerosols of varying degrees of fibrogenicity with excessive concentration. Immunological profile of patients with chronic dust bronchitis, silicosis and pneumoconiosis due to the effects of highly dispersed welding aerosols is studied. To solve the set goals and objectives of the study at the clinical stage, 161 people of the contact group, patients with chronic dust bronchitis, silicosis and pneumoconiosis caused by the exposure to highly dispersed welding aerosols were examined. The control group included 60 people. There was also a survey of 304 people with experience of more than 10 years under the influence of high concentrations of industrial fibrogenic aerosols, who underwent an in-depth periodic medical examination at the Regional Center of Occupational Pathology where occupational risk (RR), its etiological fraction (EF) and the ratio of chances (OR) of the development of occupational respiratory diseases were assessed. The features of the course of dust lung diseases, features of the immunological profile, increase in the level of growth factors were established. This allows us to establish the features of the occurrence, course and progression of dust lung diseases, as well as to improve the quality of early diagnosis, optimize prevention strategies for this pathology.dust lung diseasesprofessional riskearly diagnosisimmune profileпылевые болезни легкихпрофессиональный рискранняя диагностикаиммунный профиль[Мартинсоне Ж.С., Калюжная Д.В., Мартиньсоне И.Ю., Ванадзиньш И.А. Предварительное исследование наночастиц в различных процессах шлифования в Латвии / В сб. материалов международного научного форума «Современные вопросы здоровья и безопасности на рабочем месте». - Минск, 2017. - С. 203-208][Чугунов В.В., Васякша Л.О. Динамка клшико-патопсихолопчних розладiв у хворих на пневмоконюз залежно вщ стади легеново! хвороби // Актуальн питання фармацевтично! i медично! науки та практики. - 2013. - № 1 (11). - С. 115-118][Серебряков П.В. Профессиональные заболевания органов дыхания. Национальное руководство / Под ред. академика РАН Н.Ф. Измерова, академика РАН А.Г Чучалина. - М.: ГЭОТАР-Медиа, 2015. - 792 с][Профессиональные болезни / Под редакцией академика РАН Н.А. Мухина, профессора С.А. Бабанова. -М.: ГЭОТАР-Медиа, 2018. - 576 с][Бабанов С.А., Будаш Д.С. Состояние гуморального иммунитета при хроническом пылевом бронхите и пневмокониозах от воздействия различных видов фиброгенной пыли // Известия высших учебных заведений. Поволжский регион. Медицинские науки. - 2016. - № 3. - С. 23-34][Величковский Б.Т., Фишман Б.Б. Оценка цитотоксичности пыли при изготовлении высокоглиноземных муллитовых огнеупорных глин // Гигиена и санитария. - 1999. - № 5. - С. 53-57]