Aspirantskiy Vestnik PovolzhiyaAspirantskiy Vestnik Povolzhiya2072-23542410-3764Samara State Medical University2435610.17816/2072-2354.2015.0.1-2.114-120Research ArticleEffectiveness of radiofrequency ablation for treatment of lung cancerKorolevD G-15032015151-211412011032020Copyright © 2015, Korolev D.G.2015The aim of this study was to analyze the results of our radiofrequency ablation (RFA) procedures of primary non-small cell lung cancers (NSCLC) to appreciate the effectiveness of this method. Twenty-eight lesions in 28 patients who underwent RFA from April 2008 to December 2009 were analyzed (20 - adenocarcinoma, 5 - squamous cell carcinoma, 2 - neuroendocrine carcinoma, 1 - clear cell carcinoma). On the basis of the clinical-radiological alterations that were revealed at the first computed tomography (CT) scan and at the subsequent computed tomography, we evaluated the success of total ablation, local control of tumor and one-, three- and five-year survival rate. The complications after RFA were also evaluated. At the first CT scan complete ablation (CA) was obtained in 100%. Nine patients (32.1%) had local recurrence during the follow-up (48 months on the average). Overall survival at 1, 3 and 5 years was 89.2%, 67.7% and 39.5 %, respectively. There were no major complications. Pneumothorax occurred in 4 (14.3%) out of 28 treatment sessions: 1 was asymptomatic, and 3 required thoracostomy. Pleuritis occurred in one (3.6%) session and one more patient (3.6%) had lung abscess in the RFA area. Conclusion: Radiofrequency ablation of NSCLC was effective, well tolerated, with satisfying overall survival. However, to determine the role of RFA in the treatment of patients with non-small cell lung cancer, we need to compare RFA with surgery and radiation therapy.non-small cell lung cancerradiofrequency ablationperipheral lung tumorRFAпериферическая опухоль легкогонемелкоклеточный рак легкогорадиочастотная абляция (РЧА)[Долгушин Б.И., Косырев В.Ю., Рампрабанант С. Радиочастотная аблация в онкологии // Практическая онкология. - 2007. № 4. С. 219-227.][Vrdoljak E., Miše K., Sapunar D., Rozga A., Marušić M. Survival analysis of untreated patients with non-small-cell lung cancer // Chest. - 1994. 106(6):1797-1800.][Ginsberg R.J., Rubinstein L.V. Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. The Annals of Thoracic Surgery. - 1995. 60(3): 615-623.][Bach P.B., Cramer L.D., Warren J.L., Begg C.B. Racial differences in the treatment of early-stage lung cancer // The New England Journal of Medicine. - 1999. 341(16):1198-1205.][Qiao X., Tullgren O., Lax I., Sirzen F., Lewensohn R. The role of radiotherapy in treatment of stage I non-small cell lung cancer // Lung Cancer. - 2003. 41(1):1-11.][Hiraki T., Gobara H., Mimura H., Matsui Y., Toyooka S., and Kanazawa S. Percutaneous radiofrequency ablation of clinical stage I non-small cell lung cancer // The Journal of Thoracic and Cardiovascular Surgery. - 2011. Vol. 142. № 1. Р. 24-30.][Hiraki T., Gobara H., Iishi T.et al. Percutaneous radiofrequency ablation for clinical stage I non-small cell lung cancer: results in 20 nonsurgical candidates // The Journal of Thoracic and Cardiovascular Surgery. - 2007. Vol. 134. № 5. Р. 1306-1312.][Королев Д.Г., Скупченко А.В., Скобельцов Д.А., Королева О.Л. Оценка местного контроля опухоли легкого после радиочастотной абляции. Совершенствование медицинской помощи при онкологических заболеваниях, включая актуальные проблемы детской гематологии и онкологии. Национальная онкологическая программа. - 2009. С. 249.][Dupuy D.E., Zagoria R.J., Akerley W., Mayo-Smith W.W., Kavanagh P.V., Safran H. Percutaneous radiofrequency ablation of malignancies in the lung // The American Journal of Roentgenology. - 2000. 174(1): 57-59.][Каганов О.И. Оценка результативности хирургического лечения колоректальных метастазов в легкие с применением метода радиочастотной аблации // Общественное здоровье и здравоохранение. - 2009. № 3. С. 72-78.][Каганов О.И., Козлов С.В., Кутырёва Ю.Г., Труханова И.Г. Результаты паллиативного хирургического лечения метастазов колоректального рака в легкие // Паллиативная медицина и реабилитация. -2011. № 3. С. 31-33.][Hiraki T., Gobara H., Iguchi T., Fujiwara H., Matsui Y., Kanazawa S. Radiofrequency ablation for early-stage nonsmall celllung cancer // BioMed Research International. - 2014. P. 2-11.][Crabtree T. D., Puri V., Robinson C.et al. Analysis of first recurrence and survival in patients with stage I non-small cell lung cancer treated with surgical resection or stereotactic radiation therapy // The Journal of Thoracic and Cardiovascular Surgery. - 2014. Vol. 147. № 4. Р. 1183-1192.][Crabtree T.D., Puri V., Timmerman R. et al. Treatment of stage I lung cancer in high-risk and inoperable patients: comparison of prospective clinical trials using stereotactic body radiotherapy (RTOG 0236), sublobar resection (ACOSOG Z4032), and radiofrequency ablation (ACOSOG Z4033) // The Journal of Thoracic and Cardiovascular Surgery. - 2013.Vol. 145. №. 3. Р. 692- 699]