Aspirantskiy Vestnik PovolzhiyaAspirantskiy Vestnik Povolzhiya2072-23542410-3764Samara State Medical University2513310.17816/2072-2354.2010.0.3-4.236-239The antioxidant therapy of toxicity induced by transplantable carcinoma and irradiationSkopinP Iskopinpi@mail.ru15062010103-423623911032020Copyright © 2010, Skopin P.I.2010The objective of the study was the investigation of the status of oxidative damage in rats with transplantable cholangiocellular RS-1 carcinoma. We investigated the ability of derivative LBK-149 oxinicotinic acid to control oxidative damage induced by tumor and irradiation. LBK-149 at a dose of 100 mg/kg was injected i.p. or i.m. before or after irradiation. Biochemical methods were used for this investigation. The greatest therapeutic efficiency has noted been at a combination LBK-149 after irradiation, in comparison with monoirradiation and preventive injection of a LBK-149. It was shown that injection LBK-149 (100 mg/kg) in 10 day after irradiation has allowed to increase a doze of irradiation up to 5 Gy without increase of level of oxidative damage.lipid peroxidation, antioxidant drugs, transplantable cholangiocellular RS-1 carcinoma, anticancer radiotherapyантиоксиданты, противоопухолевая лучевая терапия, перекисное окисление липидов, перевиваемый холангиоцеллюлярный рак РС-1[1. Виноградов В.М. Перспективные методики лучевой терапии // Практическая онкология. - 2007. - т. 8. - № 4. - С. 194-203.][2. Kumaraguruparan R., Subapriya R., Kabalimoorthy J., Nagini S. Antioxidant profile in the circulation of patients with fibroadenoma and adenocarcinoma of the breast // Clin. Biochem. - 2002. - vol. 35. - №4. - P. 275-279.][3. Ladas E.J., Jacobson J.S., Kennedy D.D. et al. Antioxidants and cancer therapy: a systematic review // J. Clin. Oncol. - 2004. - vol. 1. - №22(3). - P. 517-528.][4. Lawenda B.D., Kelly K.M., Ladas E.J. et al. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? // J. Natl. Cancer Inst. - 2008. - vol. 4. - №100(11). - P. 773-783.][5. Prasad K.N., Cole W.C., Kumar B., Che Prasad K. Pros and cons of antioxidant use during radiation therapy // Cancer Treat. Rev. - 2002. - vol. 28. - №2. - P. 79-91.][6. Roszkowski K., Gackowski D., Rozalski R. et al. Small field radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism // Int. J. Cancer. - 2008. -vol. 15. - №123(8). - P. 1964-1967.][7. Skrzydlewska E., Sulkowski S., Koda M. et al. Lipid peroxidation and antioxidant status in colorectal cancer // World J. Gastroenterol. - 2005. - vol. 21. - 11(3). - P. 403-406.]