Vol 18, No 1-2 (2018)

Articles
INVESTIGATION OF THE MORPHOLOGIOAL STATE OF THE OEREBELLAR OORTEX IN WHITE RATS AND THEIR BEHAVIORAL REACTIONS AFTER CRANIOCEREBRAL INJURY
Shubina O.S., Egorova M.V.
Abstract
The article presents the results of a morphological study of the neurons of the cerebellar cortex and the behavior of sexually mature white male rats in case of craniocerebral injuries. It is shown that the experimental traumatizing caused persistent changes in the neurons of the cerebellar cortex in animal and led to deviation in animal behavior.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):6-11
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THE OHARAOTERisTic oF MAiN GELL DiFFERoNEs iN uTERINE OERviX DEFiNITivE TiSSUES
Grigoryeva Y.V., Suvorova G.N., Tulaeva O.N., Kulakova O.V., Vologdina N.N., Chemidronov S.N.
Abstract
We investigated the principal role of fibroblastic and smooth muscles cell differones in human and rat uterine cervix. The predominance of smooth muscle differon in a rat and fibroblastic differon in human results from specific differentiation due to the tissue functional features. Smooth muscle tissue is known to have contractile function and be able to perform temporally blocking, but not support function. We reveal the connective tissue predominance in human cervix results from the necessity to retain the fetus in uterine cavity during pregnancy in two-leg uprightness in evolution.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):12-16
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HPLC OF THE COMPLEX OF TERPENOIDS OF EUCALYPTUS VIMINALIS LABILL
Lаpinа A.S., Varina N.R., Kurkin V.A., Avdeeva E.V., Platonov I.A., Nikitchenko N.V.
Abstract
The article describes the problems of phytochemical investigation of Eucalyptus viminalis leaves and the complex of terpenoids as biologically active compounds in particular. The article also analyzes the possibility to detection the most pharmacologically important group such as phenolaldehydes of terpenoids (euglobals) by means of chromatographic methods (TLC and HPLC). As a result of the research, the methods of qualitative and quantitative analysis were developed. They allow to estimate the identification and quality of medicinal plant materials and medicines of Eucalyptus viminalis.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):17-21
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COMPARATIVE PHYTOCHEMICAL STUDY OF THE FRUITS, SHOOTS AND FLOWERS OF SOME HAWTHORN SPECIES
Morozova T.V., Kurkin V.A., Pravdivtseva O.E., Zhavkina T.M., Rozno S.A.
Abstract
The article is devoted to comparative phytochemical study of the fruits, shoots and flowers of some hawthorn species. The results of the research and the conclusions are presented in the paper. The results of the conducted study confirmed the difference in the raw material chemical composition of different species of hawthorn. It was also found that the hawthorn shoots collected during flowering are the promising type of medicinal plant raw material. In addition, it was determined that further studies of the raw material of Crategus submollis Sarg. are rational.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):22-24
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IMPLEMENTATION OF THE FEDERAL DRUG ASSISTANOE PROGRAM IN THE PRIVOLZHSKY FEDERAL DISTRIOT, ANALYSIS OF INDIOATORS
Petrukhina I.K., Yagudina R.I., Egorova A.V., Ryazanova T.K.
Abstract
The article is devoted to the analysis of the implementation of the federal drug assistance program for the population of the Privolzhsky Federal District (PFD). The main indicators of the program are considered on the example of ten federal subjects of PFD (Russia) were compared; they are total funding, the cost structure for the federal program implementation which depends on the groups of benefit recipient and categories of diseases; appealability of federal benefit recipients to medical organizations for prescribed medicines; actual individual consumption per capita; formulation indicators of the program. The results of the study made it possible to reveal regional features of public drug supply for federal benefit recipients.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):25-32
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HYGiENic assessment of the NuTRiTioNAL status of vARious popuLATioN groups with the use of instrumental methods of diagnosis
Gavryushin M.Y., Sazonova O.V., Gorbachev D.O., Frolova O.V.
Abstract
The article studies the nutritional status of children (n = 1014) and able-bodied adult (n = 827) population of the Samara region. The results of research and evaluation of anthropometric indicators of children are presented. The proportion of children with disharmonic physical development due to excess or lack of body weight was revealed. BIA indicators analysis as well as the data of physical development revealed the children who have excess body weight due to high values of skeletal muscle mass. Body composition analysis of the able-bodied population showed that fat mass prevails in women while skeletal muscle mass in men. The analysis of fat mass content in the group of ablebodied population with excess nutritional status (BMI more than 25 kg/m2) revealed both men and women who had a high proportion of skeletal muscle mass, which determined their excess body weight in terms of BMI. The results of the study prove bioimpedance analysis to be an informative method of the nutritional status analysis.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):33-38
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A MODERN APPROACH ТО THE ASSESSMENT OF THE NUTRITIONAL STATUS OF THE population
Gorbachev D.O., Borodina L.M., Gavryushin M.Y., Tupikova D.S.
Abstract
The article is devoted to topical issues of modern assessment of the actual nutrition of the population and nutritional status. The study of the state of nutrition is based on a multi-level assessment which includes monitoring of individual and organized groups nutrition as well as households. To achieve these goals the authors used a questionnaire-survey method based on a specially developed online form, the parameters of food status were studied using modern methods of component assessment of body composition, indirect calorimetry, characteristics of metabolic status. The data obtained in the course of a comprehensive study of the nutrition state of the population allowed to develop a system of preventive measures aimed at correcting diets, reducing the risks of alimentary-dependent diseases.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):39-44
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CHARACTERISTICS OF PATIENTS WITH PROSTATE CANCER ACCORDING TO THE DATA OF THE POPULATION CANCER REGISTRY
Suslin S.A., Somov A.N.
Abstract
The article presents the material of the population cancer registry of the Samara Regional Clinical Oncology Dispensary concerning patients with prostate cancer diagnosed in the period from 2007 to 2016. The distribution of pathology according to age and area is shown. The structure of newly diagnosed prostate cancer (hereinafter referred to as prostate cancer) was analyzed for stages, methods of detection, and reasons for neglect. Within the past 10 years, Samara region has registered an increasing incidence in the number of newly diagnosed prostate cancer, most of cases are revealed in city dwellers. Performed anti-cancer measures are aimed at the early diagnosis and decrease in development of advanced cases. Nevertheless, the main cause of neglect are defects in the healthcare delivery to patients with prostate cancer.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):45-51
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ABNORMAL UTERINE BLEEDING IN ADOLESCENTS (DATA OBTAINED IN THE REPUBLIC OF MORDOVIA)
Labzina M.V., Kuzmina Y.S., Kuptsovа S.V., Soldatov O.M.
Abstract
The work is devoted to one of the most important problems of modern gynecology - abnormal uterine bleeding of the pubertal period. The authors studied the indicators of the system of hemostasis, the hormonal profile of girls with AMPP. The data on the effectiveness of the treatment are analyzed. Conclusions are drawn about the main causes of this pathology in different age groups. The results obtained can serve as an incentive for the development of new algorithms for diagnosis and treatment of girls with abnormal uterine bleeding in the pubertal period.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):52-58
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EVALUTION OF THE PREDICTIVE ABILITY OF THE SCALES FOR RISK DEVELOPMENT STRATIFICATION OF ST, RISK-PCI AND PARIS STENT THROMBOSIS IN PATIENTS AFTER PERCUTANEOUS CORONARY INTERVENTION
Voronova I.L.
Abstract
The article studies the problems concerning the prevention of the stent thrombosis development after the invasive percutaneous coronary intervention in patients with acute coronary syndrome with ST segment elevation. The research was performed in the Samara Regional Clinical Cardiologic Dispensary within the period of 01.01.2012 to 31.12.2017. The aim was to predict the development of stent thrombosis. According to the current classification of the Academic Research Consortium patients with a definite stent thrombosis were examined. To identify the risk group, the ST, RISK-PCI and PARIS scales have been filled in for each patient. However, they have shown a low predictive ability to diagnose stent thrombosis in a high-risk group.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):59-66
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EFFECT OF MELDONIUM ON THE QUALITY OF LIFE OF PATIENTS WITH VALVULAR HEART DISEASE AND ANGINA PECTORIS AFTER HEART VALVE SURGERY
Konstantinov D.Y., Galin P.Y.
Abstract
The article presents the results of treatment of patients with heart valves pathology. The study included 40 patients, aged - 42-68 years. Postoperatively the main group took in addition to the AAT therapy of Mildronate 500 mg 2 times a day for 6 months. Obtained data allow to conclude that the inclusion of Mildronate in combined therapy of patients with valvular heart disease and the syndrome of angina pectoris after cardiac correction helps to improve the quality of life of patients mainly by improving exercise capacity that is accompanied by an increase of satisfaction with treatment.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):67-72
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CARDIOVASCULAR RISK FACTORS AMONG HIGHER SCHOOL STUDENTS (REGISTRY MMM17)
Rubanenko О.А., Rubanenko А.О., Kirichenko N.А., Kochergina А.М., Leonova V.O., Okunev I.М.
Abstract
The article studies cardiovascular risk factors among young people. 278 students from Samara and Kemerovo (Russian Federation) universities (26.6% males, mean age 21.4 ± 2.7 years) were examined. They were offered a questionnaire which estimated age, gender, body mass index, smoking, alcohol consumption and also ischemic heart disease, stroke or diabetes mellitus. Blood pressure and pulse rate were also measured. According to our data students in Samara and Kemerovo have such cardiovascular risk factors as smoking (11.5%), overweight (12.2%), obesity (4%), alcohol consumption (35.3%), hypertension (3.6%).
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):73-79
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COMPARATIVE CHARACTERISTICS OF PATIENTS WITH CHRONIC VIRAL HEPATITIS - OF DIFFERENT ETIOLOGY IN THE SAMARA REGION
Zayceva E.A., Popova L.L., Konstantinova E.A.
Abstract
This paper presents an analysis of the results of complex examination of patients with chronic hepatitis B, C and · mixed (B + C) living in the Samara region. The main clinical-epidemiological, laboratory, instrumental data were analyzed. Patients with mixed hepatitis (B + C) were revealed to have a higher viral load of one or two viruses (mainly я on virus hepatitis C) and were characterized by an advanced stage of liver fibrosis (F3). This indicates the urgent need to initiate antiviral therapy in patients of this group.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):80-85
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EFFEOTivENEss of modern antiviral therapy iN lipid DisTREss syndrome iN patients with chronic hepatitis c
Konstantinov D.Y.
Abstract
This article is devoted to studying of the effectiveness of modern antiviral therapy with direct antiviral drugs (sofos-buvirom and daklatasvirom) in patients with chronic hepatitis С and lipidic distress syndrome. The study shows the effectiveness of treatment in this category patients to accounted for 84,4%. Reduced effectiveness of antiviral therapy with sofosbuvirom and daklatasvirom was revealed in 12,6% as compared to the group of patients with chronic hepatitis С. It was has been associated with the development of dyslipidemia, the severity of which increased with the progression of liver fibrosis. Drugs of direct antiviral activity (sofosbuvir + daklatasvir) in patients with the first stage of fibrosis (F1) decreased dyslipidemia, and in patients with the second and third stage (F2 and F3) they cause increase in haemoglobin that can deteriorate condition of target organs in case of lipid distress syndrome in patients with chronic hepatitis С and the proression of liver fibrosis.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):86-90
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CLINICAL AND MORPHOLOGICAL SUBSTANTIATION OF THE ADVANTAGES OF SURGICAL TREATMENT OF PATIENTS WITH CLASSICAL TRIGEMINAL NEURALGIA
Alekseev G.N., Lazarchuk D.M., Kamadey O.O., Chemidronov S.N.
Abstract
This work covers the methods of treatment of patients with trigeminal neuralgia, the advantage of the neurosurgical treatment. The article uses the results of the analysis of case histories, findings of clinical and neurological examinations. The results of conservative and surgical methods of treatment are analyzed, the obtained data are compared with each other. The main criteria used in the analysis of the quality of treatment are reduction of pain syndrome, reduced dosage of finlepsin taken by patients. The article describes the feasibility of surgical intervention (microvascular decompression of the trigeminal nerve root.) in patients with the classical type of trigeminal neuralgia.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):91-96
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FORECASTING AND PROPHYLAXIS OF COMPLICATIONS IN PATIENTS AFTER THE RADICAL PROSTATECTOMY
Basiashvili G.T., Gataullin I.G., Khairullina G.R.
Abstract
One of the most widespread oncological diseases in men is the prostate cancer (PC). PC takes the second place in the world among oncological diseases and the sixth cause of mortality in men induced by oncopathology. The purpose of the research is to improve surgical treatment of a prostate gland cancer. “The gold standard” of surgical treatment of PC is radical prostatectomy which is one of the most difficult operations in Oncology. It is caused by intricate topographo-anatomic relations. Materials and methods of a research. 80 patients who had undergone surgical treatment of prostate cancer were chosen by continuous sampling method within the years of 2014-2016. The retrospective analysis of major risk factors of intra- and post-operative complications has been carried out. Bleeding in the excision site, injury of the neck of the urinary bladder, injury of the rectum are the commonest intra-operative complications The postoperative period is often complicated by urinary tract inflammation, lymphorrhea, lymphocele, urine incontinence, erectile dysfunction. Improvement in quality of life is the most important task of any treatment modality, thus prognosis and development of preventive measures in case of radical prostatectomy is topical. Results. We have performed optimization of the surgical technique for prostate cancer. All patients have been divided into the main and control groups. In the main group we used the complex method of prevention of complications by means of fibrin glue. The offered method of prevention of a lymphorrhea after a radical prostatectomy allows to reduce incidence of postoperative complications, development of lymphocele, diminish the time of lymphorrhea up to 1-3 days as well as postoperative rehabilitation, and to promote early activation of patients.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):97-103
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AppucATioN of complex METHoDs of REHABILITATioN iN THE TREATMENT of patients with thyroid cancer during the early recovery period
Kozlov S.V., Sivokhina T.A., Burmistrova S.A., Briatova I.A., Rybakova N.G.
Abstract
Rehabilitation of cancer patients is not only medical but also socio-economic problem. It is topical because advances in the treatment of malignant neoplasms in recent years resulted in the increase of patients’ life span. The article aims to assess the results of complex application of physical therapy in radical treatment of 'thyroid cancer in the early postoperative period. The research includes 93 patients with a malignant tumor of a thyroid gland. Patients were separated into two group. The main group was treated with a set of physical therapy methods developed by the authors, the control group was treated with respiratory gymnastics and inhalation therapy. The article demonstrates that the use of physiotherapy treatment of postoperative complications improves the favourable results of surgical cancer treatment of the thyroid gland.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):104-108
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THE USE OF SYSTEMIC OZONE THERAPY IN COMPLEX TREATMENT OF CANCER PATIENTS WHO UNDERGO REMOTE RADIATION THERAPY
Kozlov S.V., Sivokhina T.A., Vagapova M.D., Rybakova N.G.
Abstract
Modern problems of scientific and applied medicine require large-scale implementation of highly effective methods of oncology prevention and treatment as a complex approach. This study proves the implementation of systemic ozone therapy to contribute to prevention and reduction of complications after remote radiation therapy of malignant neoplasm of various localizations. The use of systemic ozone therapy in disease prevention and treatment programs of early and late complications of radiological treatment of malignant tumors allows to reduce general and local radioreaction.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):109-115
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DIAGNOSTICS OF DENTOFACIAL ABNORMALITIES BY USING DOPPLEROGRAPHY OF THE HEAD AND NECK VESSELS
Postnikov M.A., Romadanova E.S., Osadchaya E.I., Malkina V.D.
Abstract
Malocclusion is a topical problem in orthodontics. Orthodontics deals with functional methods of investigation. They allow to solve various problems which include lower jaw movements, myoelectrical activity, the condition of temporomandibular joint and its parts, investigation of blood supply in dentofacial muscle. Special attention should be paid to the study of blood flow in the head and neck vessels in patients with malocclusion because this disorder causes disturbance of arterial haemodynamics.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):116-120
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THE VARIETY OF VESTIBULAR POSITIONS OF PERMANENT CANINES OF THE UPPER JAW IN PATIENTS WITH MESIAL OCCLUSION
Ulianova L.G.
Abstract
Deficiency of the place in the dentition causes changes in the position of the individual teeth on the upper and the lower jaws. Reducing of the size of the upper jaw sagittally and transversally leads to a lack of space for individual teeth, often canines. Their place in the dentition is variable. Macrognathy of the lower jaw and micrognathia of the upper jaw are the most frequent causes of mesial occlusion. 32 patients with mesial occlusion were examined and vestibular position of canines of the maxilla was revealed. The age of the patients ranged between 12 and 36 years, there were 15 male and 17 female patients.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):121-124
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USE OF PREOPERATIVE 3D MODELING OF SPLENECTOMY IN PATIENTS WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA
Nazarov R.M., Bystrov S.A., Katorkin S.E.
Abstract
The results of surgical treatment of 45 patients with idiopathic thrombocytopenia are analyzed in the article. All patients underwent preoperative 3D modeling. Taking into consideration the data of the virtual 3D model, we predicted the performance of one of the types of splenectomy. We also carried out the analysis of the obtained data.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):125-129
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OHARAcTERisTiOs oF THE OHEMiOAL sTRuduRE of urocoNOREMENT iN DIAGNosis AND TREATMENT oF BLADDER stoNE DisEAsE iN MiLiTARY sERViCEMEN
Magomedov J.K., Pryanichnikova M.B., Rizoev H.H., Polvonov S.B., Tagozhonov Z.F.
Abstract
1208 military servicemen of the Russian Federation and the Republic of Tajikistan who had undergone treatment in military hospitals from 2010 till 2016 were studied. The chemical structures of uroconcrements were determined. The article presents comparative analysis of finding of the diagnostic study of bladder stone disease in patients of Samara Military Hospital No 426 (Russia), Military Hospital No 451 and Central Military Hospital in Tajikistan.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):130-136
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PROFESSIONAL RISK AND THE GROWTH FACTORS FGF2, VEGF IN PREDICTING OCCUPATIONAL LUNG DISEASES
Budash D.S., Babanov S.A.
Abstract
The article is investigates occupational risk in workers with prolonged working experience who are exposed to industrial aerosols of varying degrees of fibrogenicity with excessive concentration. Immunological profile of patients with chronic dust bronchitis, silicosis and pneumoconiosis due to the effects of highly dispersed welding aerosols is studied. To solve the set goals and objectives of the study at the clinical stage, 161 people of the contact group, patients with chronic dust bronchitis, silicosis and pneumoconiosis caused by the exposure to highly dispersed welding aerosols were examined. The control group included 60 people. There was also a survey of 304 people with experience of more than 10 years under the influence of high concentrations of industrial fibrogenic aerosols, who underwent an in-depth periodic medical examination at the Regional Center of Occupational Pathology where occupational risk (RR), its etiological fraction (EF) and the ratio of chances (OR) of the development of occupational respiratory diseases were assessed. The features of the course of dust lung diseases, features of the immunological profile, increase in the level of growth factors were established. This allows us to establish the features of the occurrence, course and progression of dust lung diseases, as well as to improve the quality of early diagnosis, optimize prevention strategies for this pathology.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):137-144
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FREQUENCY, CAUSES, PATHOGENESIS, TYPES, CLASSIFICATIONS, AND CLINICAL MANIFESTATIONS OF A SECONDARY CATARACT
Bantcykina Y.V., Malov I.V., Eroshevskaya E.B., Malov V.M.
Abstract
The article contains current data about the frequency, causes, pathogenesis, and types of opacification of the posterior capsule of the lens in the long-term period after cataract removal operation. In addition, this article contains information about classifications and clinical manifestations of secondary cataract.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):145-152
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EXPERIMENTAL MODELING AND FUTURE DIRECTIONS OF HOMEOSTASIS CORRECTION IN INFLAMMATORY BOWEL DISEASES
Osikov M.V., Simonyan E.V., Bakeeva A.E., Boyko M.S., Bivalkevich V.A.
Abstract
Inflammatory bowel disease (IBD) - Crohn’s disease (CD) and ulcerative colitis (UC) are chronic diseases with an unknown etiology and pathogenesis. The medical treatment of such pathologies causes lots of adverse effects and usually doesn’t lead to the persistent remission. Studying of an etiology and pathogenesis, improvement of methods of treatment of IBD dictates need of adequate experimental modeling of UC and CD. The purpose of the article is to make an analysis of the literature, indexed in Pubmed, Medline, Russian Science Citation Index, dedicated to the IBD modeling and perspective ways of homeostasis correction during such pathologies as CD and UC. The oxazo-lone injection was determined as the most optimal way of UC modeling and the injection of trinitrobenzensulfonic acid (TNBS) for CD modeling. Economical and clinical benefits of oxazolone and TNBS usage, the results of clinical and preclinical studies and adverse events of Aloe vera, Boswellia serrata, Trigonella foenum-graecum, Andrographis paniculata, omega 3 fatty acids, Ulmus fulva, Potentilla erecta, liquorice, coenzyme Q10, vitamin B12, Cucruma longa and vitamin D are described in the analyzed literature. The critical literature analysis gives us an ability to distinguish vitamin D and Cucruma longa as perspective therapeutic agents for the development of the pharmaceuticals with anti-inflammatory, immunomodulatory and composite antioxidant effects, for UC and CDs’ treatment, causing the minimum of adverse effects. Suppositories were determined as the most optimal and perspective dosage form, used for the IBD treatment, according to the best biofarmaceutical features among the other forms.
Aspirantskiy Vestnik Povolzhiya. 2018;18(1-2):153-160
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