Vol 12, No 5-6 (2012)

During the open, controlled, parallel-group comparative study we evaluated the feasibility of supplemental silimar drug to treat moderate and severe psoriasis. We surveyed 65 patients: 30 patients in the control group (conventional therapy) and 35 patients in the studied group, to which in addition to conventional treatment (metotreсsat 5 mg every 12 hours 2-3 times a week) we administered the drug silimar at a dose of 0.2 g three times a day 30 minutes before meals for 35 days. The feature of the study is to calculate the quantitative effect of the intervention.

The study showed the high frequency of non - psychotic psychiatric disorders (113 (64.2%)) in patients with rheumatoid arthritis and their relationship with the individual - typological properties of the personality such as sensory, anxiety and introversion (p<0.05).

To increase the effectiveness of standard treatment of cerebral ischemia (CI) in children in the neonatal period, the total magnetic therapy and hyperbaric oxygenation were included. The authors' developed methods were confirmed by the RF patents. The dynamics of the main ultrasound parameters reflecting the state of the ventricular system, the structure of brain tissue and its microcirculation was analyzed. The use of non-drug therapies in treatment of cerebral ischemia contributed to the rapid regression of the size of the ventricles of the brain, restoring their shape, reducing the total index of hyperechogenicity.

Influenza and other acute respiratory viral infections take first place among infectious diseases. The most severe disease was observed in pregnant women dew to changes in immune, respiratory and cardiovascular systems. Pregnant women were hospitalized in the infectious disease clinic where they were examined. Main flu symptoms caused by a pandemic strain A H1N1 virus are fever, intoxication, tracheobronchitis. The average duration of the hectic period consists of 6 ± 1.3 days. The changes in biochemical study were characterized by low levels of blood lactate dehydrogenase (LDH) up to 300 e/l, creatine phosphokinaze (CPK) to 525 e/l. Severe influenza complications as pneumonia were observed in 15 patients (16%). Peculiarities of the severe influenza course is the lack of correlation between the clinical and radiological picture of lung complications, progression of acute respiratory distress syndrome requiring constant respiratory support.

The epilepsy associated with developted anomalies of the cerebral cortex, makes from 10 % to 25 % from total number of symptomatic epilepsies according. It has the severest course, is often the cause of attacks resistance. Clinico-epidemiological aspects of an epileptic syndrome in children with malformation of cerebral cortex are considered. significant factors of forecast epilepsy course and the influence of MCC on a disease forecast are defined. Main types of epilepsy in children with MCC are pointed out. The algorithm of diagnostics for the purpose of identification of group of risk for the prevention of development of resistant forms of a disease is offered.

The article dwells on the result of determining the level of prostacyclin in blood plasma, platelet aggregation function and plasma hemostatic factors in the elderly, and centenarians with ischemic heart disease and the patients also underwent myocardial infarction. The decrease of prostacyclin levels in blood plasma, the increase of platelet aggregation and a trend towards an increase of fibrinogen, thrombin time prolongation, and reduced fibrinolytic activity in these patients were revealed.

Prevalence, aetiology, pharmacoeconomic and pharmacoepidemiology of community-acquired pneumonia in adults are described. Community-acquired pneumonia is one of the most urgent problem of up-to-date medicine. Pneumonia causes huge economic burden. Researches are carried out, which expenses on hospitalization of health care establishments and also expenses connected with disability of the patients are studied. Modern data on pathogenic microorganisms of community-acquired pneumonia and their resistance in different regions of our country and all over the world are provided. Now pharmacoepidemiological researches are carried out in which the application of antibiotics in actual practice is studied. National guidelines and standards are useful for promoting rational treatment.

The investigation of the quality of life of patients with rheumatoid arthritis associated with secondary osteoarthritis according to HAQ In this trial it was demonstrated the comparison analysis of the quality of life of patients with rheumatoid arthritis in combination with secondary osteoarthritis according to HAQ. It was revealed the relationship between the HAQ and DAS28 (index of activity). It was carried out the evaluation of efficacy of therapy with the use of low level laser irradiation. It the end of the study we concluded that secondary osteoarthritis in patients with rheumatoid arthritis deteriorate the quality of life. Inclusion in complex treatment the laser therapy improves the quality of life and activity of the disease.

A comparative analysis of in-hospital mortality of patients with community-acquired pneumonia (CAP) in the ICU unit in 2010 compared with 2000. It was revealed that among the dead in 2010 the average age dropped to 9 years (in 2000 50,1 (± 5,3) years, in 2011 - 41.2 years (± 4,1) - (p <0.05), the prevalence of men increased from 60% to 66%, a later date treatment (13.5% in 2000, 17.3% in 2010) was noted. Among the dead patients in 2010, there were patients with HIV infection (30%), a complication of the pathogenic H1N1 influenza (10%). The number of deaths from tuberculosis consisted of 8.4%.

Lack of information about the nature of changes in leptin and its relationship with anti-inflammatory factors in the development of acute coronary events has determined the feasibility of the study. The study included patients with myocardial infarction with and without type 2 diabetes. Identified giperleptinemiya and elevated concentrations of antiinflammatory factors such as CRP and IL-6, as well as their relationship with markers of myocardial necrosis (CK-MB) and leptin can be considered as one of the most important parts of the inflammatory response in myocardial infarction, not only in patients with diabetic history, but also in patients without this comorbidity. The study may form the basis for new diagnostic and therapeutic tactics correction of metabolic abnormalities in patients with acute coronary vascular disease.

The article dwells on the study of heart rate variability during the day and night in patients with different types of diastolic left ventricular dysfunction. The data correlation analysis of heart rate variability (HRV), echocardiography, markers of diastolic left ventricular dysfunction and natriuretic peptides (NUP) in the studied patients are shown.

Purpose. The aim of this study was to evaluate the concentration of interleukin-1 receptor antagonist in hypertensive patients with varying degrees of cardiovascular complications. Materials and methods. In 161 patients with I, II grade arterial hypertension aged 35 to 56 years, divided into 3 groups depending on the risk of development of cardiovascular complications were gone examination including echocardiography, ultrasound dopplerography of brachiocephalic vessels , daily blood pressure monitoring, lipid spectrum, glucose level, creatinine level, glomerular filtration rate and IL-1(ra) concentrations in blood serum. Results. In hypertensive patients with moderate cardiovascular risk the severity of inflammatory process depends on the presence of abdominal obesity. In hypertensive patients with high risk of cardiovascular complications direct correlation between IL-1(ra) and intima-media thickening and inverse correlation between IL-1(ra) concentration and GFR was found, it can indicate the association of inflammatory process, renal damage and structural changes of vascular wall which can play a crucial role in pathogenesis of arterial hypertension and development of organ damage.

211 patients aged from 40 to 84 were surveyed. The basic survey sample was 103 hypertensive patients in the acute ischemic stroke period, the control group consisted of 78 hypertensive patients without stroke, the healthy control group included 30 apparently healthy patients. The time indices of Heart Rate Variability were estimated on the evidence of ECG monitoring. The depletion of Heart Rate Variability was diagnosed in the patients of the basic group, maximally - in case of the acute stroke. The degree of Heart Rate Variability depletion correlated with age, severity of stroke, waist circumference, body-weight index, hyperglycemia level.

In 145 pregnant women biochemical indicators of liver function while gestational pyelonephritis are studied. It is established that in the first trimester of pregnancy the inflammation of the upper urinary tract helps to reduce the compensatory capacity of the liver and is manifested by the activation of lipid peroxidation, dysproteinemia, a violation of other forms of exchange and the development of endotoxemia.

The paper presents the investigation results of taking medicine «Magne B6» effect in 500 women with signs of connective tissue dysplasia. Medical history data, the state of somatic profile are investigated, signs of connective tissue dysplasia are assessed according to T.Y. Smolnova, S.N. Budanova et al. The results of the investigation testify that taking medicine magnesium is favourable for the course of the pregnancy and makes the birth of a child be in time, warns an untimely birth, and it used as prevention of a new born child asphyxia and hypotrophy.

Undergone ozone and laser therapy 42 children with chronic bronchitis were examined. The children were divided into 4 groups: the first group was a control one, the second group consisted of the patients undergone laser therapy, the third group included the children undergone ozone therapy, the fourth group consisted of the patients undergone combined ozone and laser therapy. The best effect was noted in the group of combined use of ozone and laser therapy, in which after the treatment the indexes of bronchoalveolar lavage fluid were improved, the level of catalase was increased, succinate dehydrogenase, the amount of dien conjugate and malone dialdehyde was decreased.

The article presents the research results of serological indicators in 108 children ranging in age from 5 months to 18 years with celiac disease who are examined and treated in the gastroenterology department of N.N. Ivanova ММBI city clinical hospital №1. Antibodies to gliadine (AG) class Ig A, Ig G and antibodies to tissue transglutaminase (ATTT) are taken into account as serological markers. The increase of the AGA than АТТT is more often revealed in the examined patients. In most cases, the increased AG class IgG and most of these changes are recorded in the second group of the children. The increase of antibodies to gliadine is more frequently registered in typical celiac. In the patients with atypical form the increase as AG, so АТТT is revealed. In the children with a latent form, we identify only the increase of the AG class IgG. In the patients ranging in age from 6 to 12 month with the manifestation of celiac the increase of AG and АТТT are more often registered than in other age periods. In the early manifestations of celiac (up to 6 months) the increase of AG is only noted, АТТT remains within the age limit, which may be due to violation of the production in the children of this age.

In the article the experience of the plasma destruction of bone tissue processing zone resection in surgical treatment of patients with chondroma of long bones is presented. The observation group included 45 patients who underwent surgery at the chondro long bones of different locations. The estimation performance of the role of osteosynthesis for the early activation and prevention of pathological fractures is shown.

The results of the treatment of 130 patients with purulent complications of bone fractures are studied. 80 patients used one-stage active surgical tactics involving a radical treatment of purulent focus, the stabilization of the fracture with external fixation device and closure of the wound defects, all this led to good results in 82,5% of patients.

After the application of pleural cavity active sanitation on 44 patients ranging in age from 15 to 86 with chest injuries, complicated by hemothorax with suppressed haemorrhage, the analysis has been done. Since 2010 the method of pleural cavity active sanitation through drainage tube, invented by the author (Patent RF method invention application № 2456935, 27.07.2012, Izmaylov E.P. et al.) has been used in conservative treatment. The essence of the method is fractional lavage of pleural cavity with physiological and/or novocaine solution carried out through Bülau drain, followed by broad-spectrum antibiotic done interpleurally. 4-5 days after the injury magnet therapy and/or calcium chloride electrophoresis should be done on the chest on the side of the injury 5 to 7 times. Depending on the type of conservative treatment all patients were divided into 2 groups. The test group consisted of 60 (57,7%) patients who were treated traditionally. 36 (60%) patients with concomitant chest injuries were included in this group. The main treatment group consisted of 44 (42,3%) patients, who had active sanitation of pleural cavity. 15 (34%) patients with concomitant chest injuries were among them. The patient groups were matched by condition, age, concomitant diseases and nature of injuries. 104 patients were with chest injuries, complicated by hemothorax with suppressed haemorrhage, 9 people died (8,6%). Active sanitation of pleural cavity for patients with chest injury, complicated by hemothorax with suppressed haemorrhage, has reduced the number of thoracotomies by 28,6% and the number of deaths by 3,2%.

The article presents the dynamics analysis results of the amount of the Samara Region elderly patients in the cities and the villages, who received dental care in the period of 2007/ 2010. It is established that the growth of dental prosthetics is associated with an increase in the number of pensioners who received dentures provided by commercial services, and the share of elderly persons who received dental prosthesis provided by the budget has diminished steadily.

In the article social status of patients with gastroesophagial refluxe disease, enamel erosions is presented. Quality of live is determined and limited by physical and psychology factors. Social status of patients is a base for dentists' interference in the course of the disease in the acute period, its remission and etc. The goal of stomatological treatment during the program realization of reasonable prices treatment for the poverty and the expensive treatment for the rich people is quality of life parameters dynamic by means of somatic and psychological content increasing.

Kagocel is shown to be safe and highly clinically effective in treating the patients with recurrent herpes simplex. The drug has antiviral and immunomodulating effects, it is combined with essential formulations, well tolerated, and highly effective in the local and systemic application as monotherapy and in combination with antiviral medicine famvir, by potentiating and prolonging the therapeutic effect.

The question concerns the effectiveness of dental implants in bone tissue deficit. Based on the clinical analysis of 20 patients parallel-resonant frequency indicators for analyzing the stability of intraosseous dental implants were revealed in the following groups: the installation of implants with bone grafting to increase the alveolar crest and horizontal one when using the method of splitting the alveolar ridge.

The article is devoted to the urgent problems of medical organization evaluation. The review of existing approaches to the formation of indicators and their use for the medical organization evaluation. The basic problems of the indicators choice are identified.

In the article the analysis of domestic and foreign scientific literature on a problem of safe and good-quality water supply, for the purpose of development of the preventive hygienic actions directed on ensuring of sanitary-and-epidemiologic wellbeing, the improvement and the preservation of the population health is presented. In the work the microbiological, sanitary and chemical characteristics and hygienic aspects of quality of the centralized economic and drinking water supply in connection with influence on the population health are presented.

The legislative base analysis, defining sanitary-and-epidemiologic requirements to preservation of the environment and an inhabitancy of the person, the analysis of normative documents under the reference with narcotics and psychotropic substances are lead. The structure of the medical and pharmaceutical organizations participating in drug trafficking and psychotropic substances is studied; the assortment of medical products of controllable groups. The basic infringements of rests destruction process of the medical products in the medical organizations are revealed.

Togliatti is a region with high spreading of HIV infection among the population. It heads the list in the region and it is second in Russia. the situation of HIV spreading and tuberculosis among HIV-infected citizens of Togliatti is studied. The analysis of mortality in comorbidity of HIV / TB is presented. It is revealed that tuberculosis is a major disease and the cause of death among HIV-infected patients. The greatest risk for mortality in the infected HIV patients in 2000/20001, with the decreasing of CD4 - cells less than 200 cells in mсl. (73%) is revealed. The death from TB patients occurs at an average in 3.6 months from the date of tuberculosis manifestation. HAART prescription in these cases is not affected on the unfavorable outcome. HAART taking at an earlier date has reduced the incidence of tuberculosis among HIV-infected patients at 16%.

Within a high morbidity rate of the blood system diseases in the world the mortality and disability rates are higher in Russia than in the developed countries. 1000 cases were analyzed to define the most significant medical and social risk factors of the blood system diseases for the region.

The comparative phytochemical study of different parts of the Rúmex confértus by the method of spectrophotometry was carried out. The amounts of anthracene derivatives and flavonoids in the roots, leaves, stems and flowers of the investigated plant were determined. The perspective of the using in medicine on a level with roots of aerial parts of Rumex (leaves, stems and flowers) was grounded on.

At the present stage the innovative development demands new informative methods to control devising implantation materials for dentistry, maxillofacial surgery, traumatology, orthopaedics. Pre-clinical investigations are of great importance. The study is devoted to the methods and the results of testing on cytotoxity, biocompatibility and efficiency of hydroxyapatite-coated implant BT-1-00-titanium using cell's technologies.