A clinical case of Crohn’s disease in combination with spondyloarthritis
- Authors: Pavlenko V.V.1, Eseneeva G.A.1, Muradbekova S.O.1, Aleksandrova S.B.1, Alferov V.V.1
-
Affiliations:
- Stavropol State Medical University of the Ministry of Healthcare of Russia
- Issue: Vol 11, No 9 (2025)
- Pages: 100-105
- Section: CLINICAL CASES
- Published: 06.12.2025
- URL: https://journals.eco-vector.com/2412-4036/article/view/697929
- DOI: https://doi.org/10.18565/therapy.2025.9.100-105
- ID: 697929
Cite item
Abstract
The article presents a clinical observation of a patient with combined clinical course of Crohn’s disease and ankylosing spondylitis – chronic inflammatory diseases from the group of immune-inflammatory pathologies. Despite their different clinical focuses – gastrointestinal in case of Crohn’s disease and musculoskeletal in spondylitis – these diseases share common pathogenetic mechanisms. However, their coexistence in the same patient is rare and is of particular interest both from a diagnostic and therapeutic perspective. Such cases require a multidisciplinary approach to the patient and individualized therapy selection.
Full Text
About the authors
Vladimir V. Pavlenko
Stavropol State Medical University of the Ministry of Healthcare of Russia
Email: pavlenkovv@yandex.ru
ORCID iD: 0009-0007-7717-0840
MD, Dr. Sci. (Medicine), professor, head of the Department of internal medicine propaedeutics
Russian Federation, StavropolGulnara A. Eseneeva
Stavropol State Medical University of the Ministry of Healthcare of Russia
Email: gulj081181@yandex.ru
ORCID iD: 0009-0001-0415-7334
MD, PhD (Medicine), associate professor of the Department of internal medicine propaedeutics
Russian Federation, StavropolSaida O. Muradbekova
Stavropol State Medical University of the Ministry of Healthcare of Russia
Author for correspondence.
Email: muradbekowa@yandex.ru
ORCID iD: 0009-0002-9059-6401
MD, assistant at the Department of internal medicine propaedeutics
Russian Federation, StavropolSvetlana B. Aleksandrova
Stavropol State Medical University of the Ministry of Healthcare of Russia
Email: AleksandrovaSB@yandex.ru
ORCID iD: 0009-0001-0219-2240
MD, PhD (Medicine), associate professor of the Department of internal medicine propaedeutics
Russian Federation, StavropolVladimir V. Alferov
Stavropol State Medical University of the Ministry of Healthcare of Russia
Email: v.v.alferov@mail.ru
ORCID iD: 0009-0008-0207-4480
MD, PhD (Medicine), assistant professor of the Department of internal medicine propaedeutics
Russian Federation, StavropolReferences
- Клинические рекомендации. Болезнь Крона. Общероссийская общественная организация «Ассоциация колопроктологов России», Российская гастроэнтерологическая ассоциация. Рубрикатор клинических рекомендация Минздрава России. 2024. ID: 176_2. Доступ: https://cr.minzdrav.gov.ru/view-cr/176_2 (дата обращения – 27.10.2025). [Clinical guidelines. Crohn’s disease. Association of Proctologists of Russia, Russian Gastroenterological Association. Rubricator of clinical guidelines of the Ministry of Healthcare of Russia. 2024. ID: 176_2. URL: https://cr.minzdrav.gov.ru/view-cr/176_2 (date of access – 27.10.2025) (In Russ.)].
- Белоусова Е.А., Шелыгин Ю.А., Ачкасов С.И., Хатьков И.Е., Бакулин И.Г., Скалинская М.И. с соавт. Клинико-демографические характеристики и лечебные подходы у пациентов с воспалительными заболеваниями кишечника (болезнь Крона, язвенный колит) в РФ. Первые результаты анализа Национального регистра. Колопроктология. 2023;22(1):65–82. [Belousova EA, Shelygin YuA, Achkasov SI, Khatkov IE, Bakulin IG, Skalinskaya MI et al. Clinical and demographic features and treatment approaches for inflammatory bowel diseases (Crohn’s disease, ulcerative colitis) in Russia. The primary results of the analysis of the National Register. Koloproktologiya = Coloproctology. 2023;22(1):65–82 (In Russ.)]. EDN: IMBCQN. https://doi.org/10.33878/2073-7556-2023-22-1-65-822023
- Gomollon F, Dignass A, Annese V, Tilg H, Van Assche G, Lindsay JO et al. European evidence-based consensus on the diagnosis and management of Crohn`s disease 2016: Part 1: Diagnosis and medical management. J Crohns Colitis. 2017;11(1):3–25. PMID: 27660341. https://doi.org/10.1093/ecco-jcc/jjw168
- Rogler G, Singh A, Kavanaugh A, Rubin DT. Extraintestinal manifestations of inflammatory bowel disease: Current concepts, treatment, and implications for disease management. Gastroenterology. 2021;161(4):1118–32. PMID: 34358489. PMCID: PMC8564770. https://doi.org/10.1053/j.gastro.2021.07.042
- Luchetti MM, Benfaremo D, Bendia E, Bolognini L, Fava G, Marini F et al. Clinical and patient reported outcomes of the multidisciplinary management in patients with inflammatory bowel disease-associated spondyloarthritis. Eur J Intern Med. 2019;64:76–84. PMID: 31047747. https://doi.org/10.1016/j.ejim.2019.04.015
- Bieber A, Fawaz A, Novofastovski I, Mader R. Antitumor necrosis factor-alpha therapy associated with inflammatory bowel disease: Three cases and a systematic literature review. J Rheumatol. 2017;44(7):1088–95. PMID: 28412712. https://doi.org/10.3899/jrheum.160952
- Guillo L, D’Amico F, Danese S, Peyrin-Biroulet L. Ustekinumab for extra-intestinal manifestations of inflammatory bowel disease: A systematic literature review. J Crohns Colitis. 2021;15(7):1236–43. PMID: 33367674. https://doi.org/10.1093/ecco-jcc/jjaa260
Supplementary files
