An elderly patient with bronchial asthma in real-time medical practice

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The relevance of this study is due to the lack of characteristic of elderly patients with bronchial asthma (BA) taking into account comorbidity in real-time medical practice.

The aim: to characterize patients over 65 years of age with BA in a real-time clinical settings.

Material and methods. A multicenter, cross-sectional, retrospective cohort study was performed. It involved 565 patients with BA, who were divided into two age groups: Group 1 (main group) – patients over 65 years of age (n = 423), Group 2 (comparison group) – patients aged 45–65 years (n = 142). The analysis included a review of outpatient records, medical history, assessment of the Charlson Comorbidity Index, determination of asthma control, and a study of pharmacotherapy.

Results. The study revealed significant differences in the clinical course of BA across different age groups. Patients over 65 years of age were found to have higher comorbidity (Charlson index 4.09 ± 1.40 vs. 1.75 ± 1.49 in the 45–65 age group), later disease onset (age at diagnosis 57.95 ± 14.2 vs. 44.78 ± 11.35 years), and higher doses of inhaled glucocorticosteroids (598.29 vs. 494.91 mcg/day). Cluster analysis of 565 patients revealed significant characteristic peculiarities of elderly patients with BA.

Conclusion. The study demonstrates the need for a differentiated approach to the management of patients with bronchial asthma in different age groups. The identified differences in BA clinical course require special attention to elderly patients, taking into account the higher comorbidity and later disease diagnosis in this group.

About the authors

Evgeny O. Baev

I.I. Mechnikov North-Western State Medical University; City Polyclinic No. 78, Saint Petersburg

Email: eobaev@yandex.ru
ORCID iD: 0009-0004-0438-8310

MD, 2nd-year resident of the Department of family medicine, general practitioner

Russian Federation, Saint Petersburg; Saint Petersburg

Vitaly I. Kupaev

I.I. Mechnikov North-Western State Medical University

Author for correspondence.
Email: vk1964sam@rambler.ru
ORCID iD: 0000-0003-2639-0003

MD, Dr. Sci. (Medicine), professor, professor of the Department of family medicine

Russian Federation, Saint Petersburg

Arseniy N. Popchenkov

I.I. Mechnikov North-Western State Medical University

Email: popchenkovarsenii619@gmail.com
ORCID iD: 0009-0007-5806-0443

6th year student

Russian Federation, Saint Petersburg

Anastasia N. Sanatina

City Polyclinic No. 78, Saint Petersburg

Email: sanatina.ana@mail.ru
ORCID iD: 0009-0000-5407-5540

MD, pulmonologist of the highest qualification category

Russian Federation, Saint Petersburg

Evgeny E. Shlepnev

City Polyclinic No. 78, Saint Petersburg

Email: esch78pol@mail.ru
ORCID iD: 0009-0008-5658-6633

MD, head

Russian Federation, Saint Petersburg

References

  1. Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. Updated 2024. URL: https://ginasthma.org/wp-content/uploads/2024/05/GINA-2024-Strategy-Report-24_05_22_WMS.pdf (date of access – 17.12.2025).
  2. Гайнитдинова В.В., Александрова А.А., Евдокимова С.А. Бронхиальная астма пожилых: особенности диагностики, клинического течения и подходы к лечению. Фарматека. 2025;32(9):24–30. [Gaynitdinova VV, Aleksandrova AA, Evdokimova SA. Bronchial asthma in the elderly: Diagnostic features, clinical course, and treatment approaches. Farmateka. 2025;32(9):24–30 (In Russ.)]. EDN: DIQNZC. https://doi.org/10.18565/pharmateca.2025.9.24-30
  3. Трибунцева Л.В., Будневский А.В., Прозорова Г.Г., Олышева И.А., Хохлов Р.А. Качество жизни пациентов с бронхиальной астмой: влияние избыточной массы тела, ожирения и мультиморбидности. Российский семейный врач. 2024;28(2):51–60. [Tribuntceva LV, Budnevsky AV, Prozorova GG, Olysheva IA, Khokhlov RA. Quality of life of patients with asthma: The effects of overweight, obesity and multi-morbidity. Rossiyskiy semeynyy vrach = Russian Family Doctor. 2024;28(2):51–60 (In Russ.)]. EDN: ROLRJO. https://doi.org/10.17816/RFD627462
  4. Трибунцева Л.В., Будневский А.В., Чопоров О.Н., Олышева И.А., Раскина Е.А. Оценка уровня витамина D у пациентов с бронхиальной астмой и мультиморбидной патологией. Российский семейный врач. 2025;29(3):45–54. [Tribuntceva LV, Budnevsky AV, Choporov ON, Olysheva IA, Raskina EA. Assessing vitamin D levels in patients with asthma and polymorbidity. Rossiyskiy semeynyy vrach = Russian Family Doctor. 2025;29(3):45–54 (In Russ.)]. EDN: MAHIXN. https://doi.org/10.17816/RFD678170
  5. Nogueira-Garcia B, Alves M, Pinto FJ, Caldeira D. The association between asthma and atrial fibrillation: Systematic review and meta-analysis. Sci Rep. 2024;14(1):2241. PMID: 38278854. PMCID: PMC10817980. https://doi.org/10.1038/s41598-023-50466-w
  6. Tattersall MC, Dasiewicz AS, McClelland RL, Gepner AD, Kalscheur MM, Field ME et al. Persistent asthma is associated with increased risk for incident atrial fibrillation in the MESA. Circ Arrhythm Electrophysiol. 2020;13(2):e007685. PMID: 32013555. https://doi.org/10.1161/CIRCEP.119.007685
  7. Трибунцева Л.В., Будневский А.В., Прозорова Г.Г., Чопоров О.Н., Олышева И.А., Саввина Я.М. Возможности реабилитации мультиморбидных пациентов с бронхиальной астмой и ожирением. Российский семейный врач. 2024;28(3):46–57. [Tribuntceva LV, Budnevsky AV, Prozorova GG, Choporov ON, Olysheva IA, Savvina YaM. Opportunities to rehabilitation of multimorbid patients with asthma and obesity. Rossiyskiy semeynyy vrach = Russian Family Doctor. 2024;28(3):46–57 (In Russ.)]. EDN: EFWPFW. https://doi.org/10.17816/RFD635510
  8. Charlson ME, Pompei P, Ales KL, McKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chron Dis. 1987;40(5):373–83. PMID: 3558716. https://doi.org/10.1016/0021-9681(87)90171-8
  9. Busse, PJ, Kilaru K. Complexities of diagnosis and treatment of allergic respiratory disease in the elderly. Drugs Aging.2009;26(1):1–22. PMID: 19102511. https://doi.org/10.2165/0002512-200926010-00001
  10. Song WJ, Chang YS. Respiratory allergies in the elderly: Findings from the Korean Longitudinal Study on Health and Aging phase I study (2005–2006). Asia Pac Allergy. 2017;7(4):185–92. PMID: 29094015. PMCID: PMC5663745. https://doi.org/10.5415/apallergy.2017.7.4.185
  11. Ventura MT, Scichilone N, Paganelli R, Minciullo PL, Patella V, Bonini M et al. Allergic diseases in the elderly: Biological characteristics and main immunological and non-immunological mechanisms. Clin Mol Allergy. 2017:15:2. PMID: 28174512. PMCID: PMC5290673. https://doi.org/10.1186/s12948-017-0059-2
  12. Khosa JK, Louie S, Lobo Moreno P, Abramov D, Rogstad DK, Alismail A et al. Asthma care in the elderly: Practical guidance and challenges for clinical management – a Framework of 5 “Ps”. J Asthma Allergy. 2023:16:33–43. PMID: 36636705. PMCID: PMC9829983. https://doi.org/10.2147/JAA.S293081

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2026 “Bionika Media” LLC