Parameters of hemodynamics in patients with chronic obstructive pulmonary disease, measured by oscillometry

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Abstract

Heart and pulmonary diseases have common risk factors and pathological processes that contribute to progressive impairment of respiratory function and hemodynamics. Therefore, early detection of the risk factors of cardiovascular diseases (CVD) development in patients with chronic obstructive pulmonary disease (COPD) is essential.

The aim: to study hemodynamic parameters using volumetric compression oscillometry in patients with COPD.

Material and methods. The study included 133 subjects aged 40 to 64 years (mean age 56 [52; 60] years). Study group consisted of 109 patients with COPD, and the control group consisted of 24 apparently healthy individuals. The study groups were comparable for gender (p = 0.341), age (p = 0.055), and smoking status. Hemodynamic parameters were assessed using volumetric compression oscillometry by means of the APCO-8-RIC-M device.

Results. Patients with COPD, comparatively with the control group, had higher cardiac output (5.25 [4.0; 5.6] vs. 4.3 [4.4:4.5] L/min, p = 0.002) and lower total peripheral vascular resistance (1392 [1243; 1671] vs. 1729 [1637; 1735] dyn × s × cm-5, p = 0.002). An analysis of hemodynamic parameters depending on the severity of COPD also revealed that higher disease severity was associated with higher cardiac output, cardiac index, stroke volume, and stroke index (in all cases, p < 0.001).

Conclusion. As measured by volumetric compression oscillometry, the presence of COPD in a patient affects cardiac output and total peripheral vascular resistance. With increasing COPD severity, hemodynamic parameters measured by volumetric compression oscillometry are getting to be worse.

About the authors

Zharkynay K. Kanatbekova

Academician I.P. Pavlov Ryazan State Medical University

Author for correspondence.
Email: janya_kanatbekova@mail.ru
ORCID iD: 0000-0003-3314-760X

MD, postgraduate student of the Department of faculty therapy named after professor V.Y. Garmash

Russian Federation, Ryazan

Anton V. Shakhanov

Academician I.P. Pavlov Ryazan State Medical University

Email: shakhanovav@gmail.com
ORCID iD: 0000-0002-5706-9418

MD, PhD (Medicine), associate professor, associate professor of the Department of faculty therapy named after professor V.Ya. Garmash

Russian Federation, Ryazan

Oleg M. Uryasyev

Academician I.P. Pavlov Ryazan State Medical University

Email: uryasev08@yandex.ru
ORCID iD: 0000-0001-8693-4696

MD, Dr. Sci. (Medicine), professor, head of the Department of faculty therapy named after professor V.Ya. Garmash

Russian Federation, Ryazan

Alexander A. Nikiforov

Academician I.P. Pavlov Ryazan State Medical University

Email: a.nikiforov@rzgmu.ru
ORCID iD: 0000-0002-7364-7687

MD, PhD (Medicine), associate professor, head of the Central research laboratory

Russian Federation, Ryazan

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