Irritable bowel syndrome and functional dyspepsia: Mechanisms of comorbidity

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Abstract

Functional gastrointestinal disorders occupy leading positions of applying for medical care to general practitioners, therapists, and gastroenterologists. However, managing this cohort of patients is challenging. Among the many clinical variants of functional gastrointestinal disorders, the most common are irritable bowel syndrome (IBS) and functional dyspepsia (FD), with a significant proportion of patients experiencing comorbidity. It is supposed that this comorbidity is based on common risk factors and the universality of the pathogenetic links of IBS and FD, the study of which is of great importance, including for the subsequent development of highly effective treatment regimens that can achieve sustained remission of these diseases. Current review is devoted to analysis and systemization current scientific data concerning the key pathogenesis links underlying the development of the comorbid course of IBS and FD.

About the authors

Darya A. Gavrilenko

Omsk State Medical University

Author for correspondence.
Email: gavrilenko_darya17@bk.ru
ORCID iD: 0000-0001-5245-7190
SPIN-code: 1435-9150

MD, assistant at the Department of faculty therapy and gastroenterology

Russian Federation, Omsk

Olga V. Gaus

Omsk State Medical University

Email: gaus_olga@bk.ru
ORCID iD: 0000-0001-9370-4768
SPIN-code: 7116-8419

MD, Dr. Sci. (Medicine), associate professor, professor of the Department of faculty therapy and gastroenterology

Russian Federation, Omsk

Maria A. Livzan

Omsk State Medical University

Email: mlivzan@yandex.ru
ORCID iD: 0000-0002-6581-7017
SPIN-code: 1961-4082

MD, Dr. Sci. (Medicine), corresponding member of RAS, professor, rector, head of the Department of faculty therapy and gastroenterology

Russian Federation, Omsk

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