Diagnosis of extraintestinal manifestations of inflammatory bowel disease: A review

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Abstract

Current study is devoted to the analysis of clinical and laboratory approaches to diagnosing extraintestinal manifestations of inflammatory bowel disease (IBD). According to the review, IBD diagnosis is currently based primarily on clinical assessment, physical examination data, instrumental research methods, and the use of standardized classification criteria, while laboratory methods are auxiliary and primarily used for differential diagnostic purposes. Moreover, data of scientific literature demonstrates the systemic nature of IBD and points out to the potential for further exploration of non-invasive biomarkers reflecting the activity of extraintestinal manifestations and disease prognosis. Studying immune-inflammatory mechanisms underlying systemic lesions in case of IBD, as well as assessing the potential of extraintestinal manifestations as predictors of the underlying disease, may contribute to the improvement of diagnostic and therapeutic strategies in this patient population.

About the authors

Larisa V. Tarasova

I.N. Ulyanov Chuvash State University

Author for correspondence.
Email: tlarisagast18@mail.ru
ORCID iD: 0000-0003-1496-0689
SPIN-code: 4125-7935

MD, Dr. Sci. (Medicine), professor, head of the Department of hospital therapy

Russian Federation, Cheboksary

Yulia V. Tsyganova

I.N. Ulyanov Chuvash State University

Email: j.v.tsyganova@mail.ru
ORCID iD: 0000-0002-8339-9496
SPIN-code: 9373-7120

MD, PhD (Medicine), associate professor of the Department of hospital therapy

Russian Federation, Cheboksary

Anton A. Nikolaev

I.N. Ulyanov Chuvash State University

Email: anton_nikolaev_2001@mail.ru
ORCID iD: 0000-0002-4534-999X
SPIN-code: 9895-2042

MD, assistant at the Department of hospital therapy

Russian Federation, Cheboksary

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