TherapyTherapy2412-40362713-1823Bionika Media27674810.18565/therapy.2022.10.7-12Research ArticleStudy of macrophage infiltration of various organs’ tissues in case of COVID-19 coronavirus infectionVishnyakovDmitry S.assistant of the Department of pathological anatomynomadsoul84@gmail.comKabirovIldar R.PhD in Medicine, acting vice-rector for innovative work and digital transformation, associate professor of the Department of urology with the course of FVEildarkabirov@gmail.ruEnikeevaKadriya I.assistant of the Department of pharmacology with a course of clinical pharmacologykalya1996@mail.ruKalimullinaLiliya I.junior researcher at central scientific research laboratorylilia.kalim@mail.ruSadretdinovaLidiya D.assistant at the Department of internal medicineshuraleyka1@mail.ruTyurinAnton V.PhD in Medicine, professor, head of the Department of internal diseasesanton.bgmu@gmail.comPavlovValentin N.Dr. med. habil., professor, academician of the Russian Academy of Sciences, head of the Department of urology with the course of FVEpavlov@bashgmu.ruKzhyskowskaJulia G.Doctor of Biological Sciences, professor, head of the Department of innate immunity and immunological tolerance, Institute of immunology and transfusion medicine, Faculty of Medicine, Mannheim; head of the laboratory of translational cellular and molecular biomedicinejulia.kzhyshkowska@medma.uni-heidelberg.deBashkir State Medical University of the Ministry of Healthcare of RussiaUniversity of HeidelbergNational Research Tomsk State University1510202281071222022023Copyright © 2022, Bionika Media2022Studies of the presence of macrophages in various organs and tissues in COVID-19 are fragmented and mainly limited to the study of the lungs. The aim of the study was to determine the presence of macrophage infiltration in various organs and tissues in patients with COVID-19. Material and methods. A complex pathoanatomical study of sectional material obtained after autopsies of 23 deceased patients with the main diagnosis of COVID-19 was carried out. Results. Multiple aberrant aggregations of obese CD68 positive macrophages were found, with lesions predominantly observed in the parenchyma of the lungs and kidneys. Conclusion. CD68-positive macrophages were detected in all organs studied in COVID-19 patients, with different intensity and localization of infiltration, which may indicate a single mechanism of pathogenesis in lesions of various organs in patients with this disease.CD68SARS-CoV-2macrophagesCD68autopsy materialSARS-CoV-2макрофагиаутопсийный материал[Singhal T.A. Review of coronavirus disease-2019 (COVID-19). Indian J. 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