TherapyTherapyТерапия2412-40362713-1823Bionika Media27686810.18565/therapy.2022.10.90-97ArticlesСтатьиReview ArticlePersistent viral shedding of SARS-CoV-2 in pathogenesis of Long-COVID-19Длительная персистенция вируса SARS-CoV-2 в организме как возможный механизм патогенеза долгого COVID-19BolievaLaura Z.БолиеваЛаура Зелимхановна

Dr. med. habil., professor, head of the Department of pharmacology with clinical pharmacology

д.м.н., профессор, зав. кафедрой фармакологии с клинической фармакологией

bolievalz@mail.ruMalyavinAndrey G.МалявинАндрей Георгиевич

Dr. med. habil., professor, professor of the Department of phthisiology and pulmonology of the Faculty of general medicine

д.м.н., профессор, профессор кафедры фтизиатрии и пульмонологии лечебного факультета

maliavin@mail.ruVyalkovaAnna B.ВялковаАнна Борисовна

PhD in Medicine, associate professor of the Department of pharmacology with clinical pharmacology

к.м.н., доцент кафедры фармакологии с клинической фармакологией

vialkova.anna@yandex.ruNorth Ossetian State Medical Academy of the Ministry of Healthcare of RussiaФГБОУ ВО «Северо-Осетинская государственная медицинская академия» Минздрава РоссииA.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of RussiaФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России15102022810VOL 8, NO10 (2022)ТОМ 8, №10 (2022)909722022023Copyright ©; 2022, Bionika MediaCopyright ©; 2022, ООО «Бионика Медиа»2022Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/article/view/276868

The term «Long-COVID-19» refers to a condition when patients with COVID-19 suffer from long-term symptoms lasting more than 28 days from the onset of the disease. A number of mechanisms influencing the development of Long-COVID-19 are discussing, among which the most controversial is the possibility of long-term persistence of the SARS-CoV-2 virus in the body. The data currently available are insufficient to draw definitive conclusions about the persistence of SARS-CoV-2 in the body and its role in the development of Long-COVID-19, relapses and reinfection. At the same time, it is impossible to deny the importance of this factor as a reason of prolonged relapsing course of infection in some patients, primarily immunocompromised ones. The article presents currently available data on the long-term persistence of SARS-CoV-2 after the end of the acute period of COVID-19, potential risk factors for virus persistence and prolonged recurrent course of the disease

Термин «долгий COVID-19» обозначает состояние, при котором пациенты с новой коронавирусной инфекцией страдают от ее долгосрочных последствий, продолжающихся более 28 дней с начала заболевания. В настоящее время обсуждается ряд механизмов, оказывающих влияние на развитие Long-COVID-19, в числе которых наиболее дискутабельным является возможность длительной персистенции вируса SARS-CoV-2 в организме. Имеющихся в настоящее время данных недостаточно, чтобы сделать окончательные выводы о персистенции SARS-CoV-2 в организме и ее роли в развитии долгого COVID-19, рецидивов и реинфекции. При этом нельзя полностью отрицать значение фактора персистенции в том, что у ряда больных, прежде всего иммунокомпроментированных пациентов, COVID-19 принимает затяжное рецидивирующее течение. В статье приводятся накопленные к настоящему времени данные о длительной персистенции SARS-CoV-2 после окончания острого периода COVID-19, потенциальных факторах риска персистирующего и затяжного рецидивирующего течения заболевания.

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