TherapyTherapyТерапия2412-40362713-1823Bionika Media277662ArticlesСтатьиReview ArticleDeficiencies of magnesium and pyridoxine and the pathogenesis of the metabolic syndromeДефициты магния и пиридоксина и патогенез метаболического синдромаGromovaOlga A.ГромоваОльга Алексеевна

MD, professor of the Department of pharmacology and clinical pharmacology

д.м.н., профессор кафедры фармакологии и клинической фармакологии

unesco.gromova@gmail.comKalachevaAlla G.КалачеваАлла Геннадьевна

PhD, associated professor of the Department of pharmacology and clinical pharmacology

к.м.н, доцент кафедры фармакологии и клинической фармакологии

TorshinIvan Yu.ТоршинИван Юрьевич

candidate of physico-mathematical sciences, associate professor of the Department of intelligent systems

к.ф-м.н., доцент кафедры интеллектуальных систем

GrishinaTatiana R.ГришинаТатьяна Романовна

MD, professor, head of the Department of pharmacology and clinical pharmacology

д.м.н., профессор, зав. кафедрой фармакологии и клинической фармакологии

TapilskayaNatalia I.ТапильскаяНаталья Игоревна

MD, professor of the Department of obstetrics and gynecology

д.м.н., профессор кафедры акушерства и гинекологии

Ivanovo state medical academyФГБОУ ВО «Ивановская государственная медицинская академия»Moscow institute of physics and technology (state university)ФГБОУ ВО «Московский физико-технический институт (государственный университет)»Saint-Petersburg State pediatric medical universityФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет»150320173NO3 (2017)№3 (2017)627522022023Copyright ©; 2017, Bionika MediaCopyright ©; 2017, ООО «Бионика Медиа»2017Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/article/view/277662

Metabolic syndrome (MS) represents a set of metabolic abnormalities that increase the risk of diabetes, cardiovascular and cerebrovascular disease. The components of MS are abdominal obesity, hypertension, disturbances of lipid and carbohydrate metabolism. The pathogenesis of the MS involves complex disorders of carbohydrate and fat metabolism caused by physical inactivity, a load of bad habits as well as by macro- and micronutrient imbalances in diet. Magnesium is one of the main factors supporting the physiological metabolism of sugars and fats as magnesium ion is required for the active sites of a number of enzymes. The paper presents the results of a systematic analysis of the molecular mechanisms of effects on magnesium characteristic of MS disorders of carbohydrate and fat metabolism. The results of experimental and clinical research and the evidence-based data indicate feasibility of using organic salts of magnesium with pyridoxine in the prevention and treatment of MS.

Метаболический синдром (МС) - совокупность метаболических нарушений, приводящих к повышению риска диабета, сердечно-сосудистой и цереброваскулярной патологии. Компонентами МС являются абдоминальное ожирение, артериальная гипертония, специфические нарушения липидного и углеводного обмена. Патогенез МС предполагает комплексные нарушения углеводного и жирового метаболизма, обусловленные гиподинамией, грузом вредных привычек, нарушений макро- и микронутриентного баланса диеты. Магний является одним из главных факторов поддержки физиологического метаболизма сахаров и жиров, т.к. входит в состав активных центров соответствующих ферментов. В настоящей работе приведены результаты систематического анализа молекулярных механизмов воздействия магния на характерные для МС нарушения углеводного и жирового обмена. Рассмотрены синергидные эффекты магния и пиридоксина в оптимизации липидного и углеводного обмена. Приводятся результаты экспериментальных, клинических исследований и данные доказательной медицины, указывающие на целесообразность применения препаратов органического магния и пиридоксина в профилактике и терапии МС.

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