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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">277669</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Nolodotak (flupirtine) in treatment of patients with dorsopathy</article-title><trans-title-group xml:lang="ru"><trans-title>Нолодотак (флупиртин) в лечении пациентов с дор-сопатией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kamchatnov</surname><given-names>Pavel R.</given-names></name><name xml:lang="ru"><surname>Камчатнов</surname><given-names>Павел Рудольфович</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, professor of the Department of neurology, neurosurgery and medical genetics</p></bio><bio xml:lang="ru"><p>д.м.н., профессор кафедры неврологии, нейрохирургии и медицинской генетики</p></bio><email>pavkam7@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khanmurzaeva</surname><given-names>Naida B.</given-names></name><name xml:lang="ru"><surname>Ханмурзаева</surname><given-names>Наида Багавдиновна</given-names></name></name-alternatives><bio xml:lang="en"><p>PhD, assistant of the</p></bio><bio xml:lang="ru"><p>к.м.н., ассистент кафедры фармакологии</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khanmurzaeva</surname><given-names>Saida B.</given-names></name><name xml:lang="ru"><surname>Ханмурзаева</surname><given-names>Саида Багавдиновна</given-names></name></name-alternatives><bio xml:lang="en"><p>assistant of the Department of nervous diseases, medical genetics and neurosurgery</p></bio><bio xml:lang="ru"><p>ассистент кафедры нервных болезней, медицинской генетики и нейрохирургии</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov Russian national medical research university</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Dagestan state medical university</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Дагестанский государственный медицинский университет»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2017</year></pub-date><issue>3</issue><issue-title xml:lang="en">NO3 (2017)</issue-title><issue-title xml:lang="ru">№3 (2017)</issue-title><fpage>76</fpage><lpage>83</lpage><history><date date-type="received" iso-8601-date="2023-02-22"><day>22</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ООО «Бионика Медиа»</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/277669">https://journals.eco-vector.com/2412-4036/article/view/277669</self-uri><abstract xml:lang="en"><p>Dorsopathy (DP) is the most common variant of musculoskeletal pain syndromes. Taking into account the chronic course of the disease with a tendency to recurrence, the high incidence of comorbid conditions, the need for a large number of medications, a serious problem is the choice of an effective drug with sufficient safety for use in individual patient. The article presents data on the possibility of the use of flupirtine, an original drug with the ability to activate potassium channels, providing analgesic and anti-spasmodic effects. The safety of the drug in patients with DP is analyzed.</p></abstract><trans-abstract xml:lang="ru"><p>Дорсопатия (ДП) - наиболее распространенный вариант скелетно-мышечного болевого синдрома. Учитывая хроническое, со склонностью к рецидивированию течение заболевания, высокую частоту коморбидных состояний, потребность в приеме большого количества лекарственных препаратов, серьезной проблемой является выбор эффективного препарата, обладающего достаточной безопасностью применения у конкретного больного. Приводятся сведения о возможности применения при ДП флупиртина - препарата, обладающего способностью активировать калиевые каналы, оказывая противоболевой и противоспастический эффекты. Анализируются вопросы безопасности применения препарата у пациентов с ДП.</p></trans-abstract><kwd-group xml:lang="en"><kwd>lumbar pain</kwd><kwd>musculoskeletal pain syndromes</kwd><kwd>flupirtine</kwd><kwd>Nolodotak</kwd><kwd>treatment</kwd><kwd>hepatotoxicity</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дорсопатия</kwd><kwd>скелетно-мышечные болевые синдромы</kwd><kwd>флупиртин</kwd><kwd>Нолодатак</kwd><kwd>гепатотоксичность</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>CDC. National Ambulatory Medical Care Survey: 2010 Summary Tables. Table 9. www.cdc.gov/nchs/data/ahcd/ namcs_summary/2010_namcs_ web_tables.pdf. Accessed March 29, 2016.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Vos T., Flaxman A., Naghavi M., et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2163-96.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Davies C., Nitz A., Mattacola C., Kitzman P., Howell D., Viele K., Baxter D., Brockopp D. Practice patterns when treating patients with low back pain: a survey of physical therapists. Physiother. Theory Pract. 2014;30(6):399-408.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>American College of Radiology. ACR Appropriateness Criteria. Low back pain. 2015. www.acr.org/~/media/ACR/ Documents/AppCriteria/Diagnostic/LowBackPain.pdf. Accessed March 10, 2016.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Wong J., Cote P., Sutton D., Randhawa K., Yu H., Varatharajan S., Goldgrub R., Nordin M., Gross D.P., Shearer H.M., Carroll L.J., Stern P.J., Ameis A., Southerst D., Mior S., Stupar M., Varatharajan T., Taylor-Vaisey A. Clinical practice guidelines for the noninvasive management of low back pain: A systematic review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Eur. J. Pain. 2017;21(2):201-6.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Cutforth G., Peter A., Taenzer P. The Alberta health technology assessment (HTA) ambassador program: The development of a contextually relevant, multidisciplinary clinical practice guideline for non-specific low back pain: A review. Physiother. Can. 2011;63:278-86.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Livingston C., King V., Little A. et al. Evidence-based clinical guidelines project. Evaluation and management of low back pain: a clinical practice guideline based on the joint practice guideline of the american college of physicians and the American Pain Society. Salem, Oregon: Office for Oregon Health Policy and Research. 2011.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Баранцевич Е.Р., Андреев В.В. Возможности лечения хронической боли при пояснично-крестцовой радикулопатии. Врач. 2012;11:13-9. [Barantsevich Ye.R., Andreev V.V. Treatment options for chronic pain in lumbosacral radiculopathy. Vrach. 2012;11:13-9 (in Russ.)]</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Есин Р.Г., Есин О.Р., Ахмадеева Г.Д., Салихова Г.В. Боль в спине. Казань: Казанский полиграфкомбинат, 2010. 272 с. (Yesin R.G., Yesin O.R., Ahmadeeva G.D., Salihova G.V. Back pain. Kazan': Kazansky poligrafkombinat, 2010. 272 p. (in Russ.)]</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Chou R., Qaseem A., Snow V., Casey D., Cross J.T. Jr, Shekelle P., Owens D.K.; Clinical efficacy assessment subcommittee of the American College of Physicians; American College of Physicians; American Pain Society Low Back Pain Guidelines Panel. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann. Intern. Med. 2007;147:478-91.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Roberts E., Nunes V., Buckner S., Latchem S., Constanti M., Miller P., Doherty M., Zhang W., Birrell F., Porcheret M., Dziedzic K., Bernstein I., Wise E., Conaghan P.G. Paracetamol: not as safe as we thought? A systematic literature review of observational studies. Ann. Rheum. Dis. 2016;75:552-9.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Saragiotto B., Machado G., Ferreira M., Pinheiro M.B., Abdel Shaheed C., Maher C.G. Paracetamol for low back pain. Cochrane Database Sys. Rev. 2016;(6):CD012230.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Kötter T., da Costa B., Fässler M., Blozik E., Linde K., Jüni P., Reichenbach S., Scherer M. Metamizole-associated adverse events: a systematic review and meta-analysis. PLoS One. 2015;10(4):e0122918.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Konijnenbelt-Peters J., van der Heijden C., Ekhart C., Bos J., Bruhn J., Kramers C. Metamizole (Dipyrone) as an Alternative Agent in Postoperative Analgesia in Patients with Contraindications for Nonsteroidal Anti-Inflammatory Drugs. Pain Pract. 2017;17(3):402-8.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Gouveia N., Rodrigues A., Ramiro S., Eusébio M., Machado P.M., Canhao H., Branco J.C. The use of analgesic and other pain-relief drugs to manage chronic low back pain: results from a national survey. Pain Pract. 2017;7(3): 353-65.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>van Tulder M., Becker A., Bekkering T., Breen A., del Real M.T., Hutchinson A., Koes B., Laerum E., Malmivaara A.; COST B Working Group on Guidelines for the Management of Acute Low Back Pain in Primary Care. Chapter 3. European guidelines for the management of acute nonspecific low back pain in primary care. Eur. Spine J. 2006;15 (Suppl. 2):S169-91.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Qaseem A., Wilt T., McLean R., Forciea M.A.; Clinical Guidelines Committee of the American College of Physicians. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the American College of Physicians. Ann. Intern. Med. 2017;166(7):514-30.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Brown D., Passmore G. Neural KCNQ (Kv7) channels. Br. J. Pharmacol. 2009;156(8):1 185-95.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Fleckenstein J., Sittl R., Averbeck B., Lang P.M., Irnich D., Carr R.W. Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial. J. Transl. Med. 2013;11:34-9.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Klinger F., Bajric M., Salzer I., Dorostkar M.M., Khan D., Pollak D.D., Kubista H., Boehm S., Koenig X. 5 Subunit containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine. Br. J. Pharmacol. 2015;172(20):4946-58.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Mueller-Schwefe G. Flupirtine in acute and chronic pain associated with muscle tenseness. Results of a postmarket surveillance study. Fortschr. Med. Orig. 2003;121(1):11-8.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Worz R., Stroehmann I. Ruckemschmerzen: Leitlinien der medicamentosen therapie. Munch. Med. Wschr. 2000;142:27-33.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Uberall M.A., Mueller-Schwefe G.H., Terhaag B. Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double-blind, placebo- and active-controlled parallel-group phase IV study. Curr. Med. Res. Opin. 2012;28(10):1617-34.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Камчатнов П.Р., Батышева Т.Т., Ганжула П.А. и др. Применение катадолона у больных со спондилогенной дорсопатией. Журн. неврол. психиатр. им. С.С. Корсакова. 2006;106(11):46-9. (Kamchatnov P.R., Batysheva T.T., Ganzhula P.A. et al. Application of katadolon in patients with spondylogenic dorsopathy. S.S. Korsakov J. Nevrol. Psychiatry. 2006;106(11)46-9 (in Russ.)]</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Douros A., Bronder E., Andersohn F., Klimpel A., Thomae M., Sarganas G., Kreutz R., Garbe E. Drug-induced liver injury: results from the hospital-based Berlin Case-Control Surveillance Study. Br. J. Clin. Pharmacol. 2015;79(6):988-99.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Michel M., Radziszewski P., Falconer C., Marschall-Kehrel D, Blot K. Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years. Br. J. Clin. Pharmacol. 2012;73(5):821-5.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Nicoletti P., Werk A., Sawle A., Shen Y., Urban T.J., Coulthard S.A., Bjornsson E.S., Cascorbi I., Floratos A., Stammschulte T., Gundert-Remy U., Nelson M.R., Aithal G.P., Daly A.K.; International Drug-induced Liver Injury Consortium. HLA-DRB1*16: 01 -DQB1 *05: 02 is a novel genetic risk factor for flupirtine-induced liver injury. Pharmacogenet. Genomics. 2016;26(5):218-24.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Wörz R. Longterm treatment of chronic pain patients with flupirtine on hepatotoxicity and persistent effectiveness from 7 months to 22 years. MMW Fortschr. Med. 2014;156 (Suppl. 4):127-34.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Burkhardt H., Wehling M. Non-opioid pain medication in the elderly. Schmerz. 2015;29(4):371-9.</mixed-citation></ref></ref-list></back></article>
