TherapyTherapyТерапия2412-40362713-1823Bionika Media279244ArticlesСтатьиResearch ArticleDiagnostics and monitoring of patients with resistant arterial hypertension and obstructive sleep apnoea (Clinical recommendations)Диагностика и ведение пациентов с резистентной артериальной гипертензией и обструктивным апноэ сна (Клинические рекомендации)MalyavinAndrey G.МалявинАндрей Георгиевич

MD, professor, professor of the Department of phthisiology and pulmonology of general medicine Department of A.I. Yevdokimov Moscow state university of medicine and dentistry of the Ministry of Health of Russia, chairman of the section of respiratory medicine of Russian scientific society of physicians

д.м.н., профессор, профессор кафедры фтизиатрии и пульмонологии лечебного факультета, председатель секции респираторной медицины РНМОТ

BabakSergey L.БабакСергей Львович

MD, professor of the Department of phthisiology and pulmonology of general medicine Department of A.I. Yevdokimov Moscow state university of medicine and dentistry of the Ministry of Health of Russia, scientific secretary of the section of respiratory medicine of Russian scientific society of physicians

д.м.н., профессор кафедры фтизиатрии и пульмонологии лечебного факультета, ученый секретарь секции респираторной медицины РНМОТ

AdashevaTatyana V.АдашеваТатьяна Владимировна

MD, professor of the Department of outpatient therapy of A.I. Yevdokimov Moscow state university of medicine and dentistry of the Ministry of Health of Russia, member of the section of respiratory medicine of Russian scientific society of physicians

д.м.н., профессор, профессор кафедры поликлинической терапии, член секции респираторной медицины РНМОТ

GorbunovaMarina V.ГорбуноваМарина Валентиновна

PhD, assistant professor of the Department of phthisiology and pulmonology of general medicine Department of A.I. Yevdokimov Moscow state university of medicine and dentistry of the Ministry of Health of Russia, secretary of the section of respiratory medicine of Russian scientific society of physicians

к.м.н., доцент кафедры фтизиатрии и пульмонологии лечебного факультета, секретарь секции респираторной медицины РНМОТ

MartynovAnatoly I.МартыновАнатолий Иванович

MD, professor, academician of RAS, professor of the Department of hospital therapy № 1, A.I. Yevdokimov Moscow state university of medicine and dentistry of the Ministry of Health of Russia, president of Russian scientific society of physicians, honoured scientist of the Russian Federation, honoured doctor of the Russian Federation, laureate of the USSR government prize

д.м.н., профессор, академик РАН, профессор кафедры госпитальной терапии № 1 президент РНМОТ, заслуженный деятель науки РФ, заслуженный врач РФ, лауреат премии Правительства СССР

A.I. Yevdokimov Moscow state university of medicine and dentistry of the Ministry of Health of RussiaФГБОУ ВО «МГМСУ им. А.И. Евдокимова» Минздрава России150120181NO1 (2018)№1 (2018)44224022023Copyright ©; 2018, “Bionika Media” LLCCopyright ©; 2018, ООО «Бионика Медиа»2018“Bionika Media” LLCООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/about/editorialPolicieshttps://journals.eco-vector.com/2412-4036/article/view/279244

Mancia G., Fagard R., Narkiewicz K. et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 2013 Jul;31 (7):1281-357. DOI: 10.1097/01.hjh.0000431740.32696.cc.Mancia G., Laurent S., Agabiti-Rosei E. et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document J. Hypertens. 2009 Nov;27 (11):2121-58. DOI: 10.1097/HJH.0b013e328333146d.Mancia G., De Backer G., Dominiczak A. et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. Hypertens. 2007 Jun;25 (6):1105-87.Chow C.K., Teo K.K., Rangarajan S. et al. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA. 2013 Sep 4;310 (9):959-68. DOI: 10.1001/jama.2013.184182.Чазова И.Е. и др. Распространенность факторов риска сердечно-сосудистых заболеваний в российской популяции больных артериальной гипертонией. Кардиология. 2014;10:4-12.Оганов Р.Г. и др. Эпидемиология артериальной гипертонии в России. Результаты федерального мониторинга 2003-2010 гг. Кардиоваскулярная терапия и профилактика. 2011;10 (1):9-13.Persell S.D. Prevalence of resistant hypertension in the United States, 2003-2008. Hypertension. 2011 Jun;57 (6):1076-80. DOI: 10.1161/HYPERTENSIONAHA.111.170308.Cai A., Calhoun D.A. Resistant Hypertension: An Update of Experimental and Clinical Findings Hypertension. 2017 Jul;70 (1):5-9. DOI: 10.1161/HYPERTENSIONAHA.1 17.08929.Daugherty S.L., Powers J.D., Magid D.J. et al. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012 Apr 3;125 (13):1635-42. DOI: 10.1161/CIRCULATIONAHA.111.068064.Frohlich E.D. Classification of resistant hypertension. Hypertension. 1988 Mar;11 (3 Pt 2):II67-70.Calhoun D.A., Jones D., Textor S. et al. Resistant hypertension: diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Hypertension. 2008 Jun;51 (6):1403-19. DOI: 10.1161/HYPERTENSIONAHA.108.189141.Mazzaglia G., Mantovani L.G., Sturkenboom M.C. et al. Patterns of persistence with antihypertensive medications in newly diagnosed hypertensive patients in Italy: a retrospective cohort study in primary care. J. Hypertens. 2005 Nov;23 (1 1):2093-100.Garg J.P., Elliott W.J., Folker A. et al. Resistant hypertension revisited: a comparison of two university-based cohorts. Am J. Hypertens. 2005 May;18 (5 Pt 1):619-26.Mezzetti A., Pierdomenico S.D., Costantini F. et al. White-coat resistant hypertension. Am J. Hypertens. 1997 Nov;10 (1 1):1302-7.Bradley T.D., Floras J.S. Obstructive sleep apnoea and its cardiovascular consequences. Lancet. 2009 Jan 3;373 (9657):82-93. DOI: 10.1016/S0140-6736(08)61622-0.Kasai T., Floras J.S., Bradley T.D. Sleep apnea and cardiovascular disease: a bidirectional relationship. Circulation. 2012 Sep 18;126 (12):1495-510. DOI: 10.1161/CIRCULATIONAHA.111.070813.Somers V.K., White D.P., Amin R. et al. Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation. 2008 Sep 2;118 (10):1080-11 1. DOI: 10.1161/CIRCULATIONAHA.107.189375.Bradley T.D., Floras J.S. Sleep apnea and heart failure: Part II: central sleep apnea. Circulation. 2003 Apr 1;107 (12):1671-8.Bradley T.D., Floras J.S. Sleep apnea and heart failure: Part II: central sleep apnea. Circulation. 2003 Apr 8;107 (13):1822-6.Farney R.J., Walker B.S., Farney R.M. et al. The STOP-Bang equivalent model and prediction of severity of obstructive sleep apnea: relation to polysomnographic measurements of the apnea/hypopnea index. J. Clin Sleep Med. 2011 Oct 15;7 (5):459-65B. DOI: 10.5664/JCSM.1306.Gislason T., Almqvist M., Eriksson G. et al. Prevalence of sleep apnea syndrome among Swedish men--an epidemiological study. J. Clin Epidemiol. 1988;41 (6):571-6.Young T., Finn L., Peppard P.E. et al. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008 Aug;31 (8):1071-8.Bearpark H., Elliott L., Grunstein R. et al. Snoring and sleep apnea. A population study in Australian men. Am J. Respir Crit Care Med. 1995 May;151 (5):1459-65.Bixler E.O., Vgontzas A.N., Ten Have T. et al. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J. Respir Crit Care Med. 1998 Jan;157 (1):144-8.Bixler E.O., Vgontzas A.N., Lin H.M. et al. Prevalence of sleep-disordered breathing in women: effects of gender. Am J. Respir Crit Care Med. 2001 Mar;163 (3 Pt 1):608-13.Kasai T., Arcand J., Allard J.P. et al. Relationship between sodium intake and sleep apnea in patients with heart failure. J. Am Coll Cardiol. 2011 Nov 1;58 (19):1970-4. DOI: 10.1016/j.jacc.201 1.08.012.Siddiqui M., Dudenbostel T., Calhoun D.A. Resistant and Refractory Hypertension: Antihypertensive Treatment Resistance vs Treatment Failure. Can J. Cardiol. 2016 May;32 (5):603-6. DOI: 10.1016/j.cjca.201 5.06.033.Calhoun D.A. Obstructive sleep apnea and hypertension. Curr Hypertens Rep. 2010 Jun;12 (3):189-95. DOI: 10.1007/s11906-010-0112-8.Адашева Т.В., Задионченко В.С., Федорова И.В., Шахрай Н.Б. Резистентная VS неконтролируемая артериальная гипертензия: тактика назначения антигипертензивной терапии. Consilium medicum. 2017; №5: 20-25.Gottlieb D.J., Yenokyan G., Newman A.B. et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation. 2010 Jul 27; 122 (4):352-60. DOI: 10.1161/ CIRCULATIONAHA.109.901801.Marin J.M., Carrizo S.J., Vicente E., Agusti A.G. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005 Mar 19-25;365 (9464):1046-53.Punjabi N.M., Caffo B.S., Goodwin J.L. et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med. 2009 Aug;6 (8):e1000132. DOI: 10.1371/journal.pmed.1000132.Newman A.B., Nieto F.J., Guidry U. et al. Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study. Am J. Epidemiol. 2001 Jul 1;1 54 (1):50-9.Mabry R.L. Rhinitis of pregnancy. South Med J. 1986 Aug;79 (8):965-71.Randerath W.J., Sanner B.M., Somers V.K. (eds): Sleep Apnea. Prog Respir Res. Basel, Karger, 2006, vol 35, pp 224-237.Izci B., Vennelle M., Liston W.A. et al. Sleep-disordered breathing and upper airway size in pregnancy and post-partum. Eur Respir J. 2006 Feb;27 (2):321-7.Manconi M., Govoni V., De Vito A. et al. Restless legs syndrome and pregnancy. Neurology. 2004 Sep 28;63 (6):1065-9.Olivarez S.A., Ferres M., Antony K. et al. Obstructive sleep apnea screening in pregnancy, perinatal outcomes, and impact of maternal obesity. Am J. Perinatol. 2011 Sep;28 (8):651-8. DOI: 10.1055/s-0031-1276740.Edwards N., Blyton D.M., Kirjavainen T. et al. Nasal continuous positive airway pressure reduces sleep-induced blood pressure increments in preeclampsia. Am J. Respir Crit Care Med. 2000 Jul;162 (1):252-7.Gleadhill I.C., Schwartz A.R., Schubert N. et al. Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea. Am Rev Respir Dis. 1991 Jun;143 (6):1300-3.Younes M., Ostrowski M., Atkar R. et al. Mechanisms of breathing instability in patients with obstructive sleep apnea. J. Appl Physiol (1985). 2007 Dec;103 (6):1929-41.De Backer J.W., Vos W.G., Verhulst S.L., De Backer W. Novel imaging techniques using computer methods for the evaluation of the upper airway in patients with sleep-disordered breathing: a comprehensive review. Sleep Med Rev. 2008 Dec;12 (6):437-47. DOI: 10.1016/j.smrv.2008.07.009.Fenik P., Veasey S.C. Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus. Am J. Respir Crit Care Med. 2003 Feb 15;167 (4):563-9.Davila D.G., Richards K.C., Marshall B.L. et al. Oximeter's acquisition parameter influences the profile of respiratory disturbances. Sleep. 2003 Feb 1;26 (1):91-5.Koehler U., Hildebrandt O., Krönig J. et al. Chronic hypoxia and cardiovascular risk: Clinical significance of different forms of hypoxia. Herz. 2017 May 4. DOI: 10.1007/s00059-017-4570-5.Chiang A.A. Obstructive sleep apnea and chronic intermittent hypoxia: a review. Chin J. Physiol. 2006 Oct 31;49 (5):234-43.Khan A., Patel N.K., O'Hearn D.J., Khan S. Resistant hypertension and obstructive sleep apnea. Int J. Hypertens. 2013;2013:193010. DOI: 10.11 55/2013/193010.Peppard P.E., Young T., Palta M., Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N. Engl J. Med. 2000 May 11;342(19):1378-84.Narkiewicz K., Kato M., Phillips B.G. et al. Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea. Circulation. 1999 Dec 7;100 (23):2332-5.Nieto F.J., Young T.B., Lind B.K. et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000 Apr 12;283 (14):1829-36.Young T., Peppard P., Palta M. et al. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med. 1997 Aug 11-25;1 57 (1 5):1746-52.Haas D.C., Foster G.L., Nieto F.J. et al. Age-dependent associations between sleep-disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study. Circulation. 2005 Feb 8;111 (5):614-21.Walia H.K., Li H., Rueschman M. et al. Association of severe obstructive sleep apnea and elevated blood pressure despite antihypertensive medication use. J. Clin Sleep Med. 2014 Aug 15;10 (8):835-43. DOI: 10.5664/jcsm.3946.Dudenbostel T., Calhoun D.A. Resistant hypertension, obstructive sleep apnoea and aldosterone. J. Hum Hypertens. 2012 May;26 (5):281-7. DOI: 10.1038/jhh.2011.47.Grote L., Hedner J., Peter J.H. Sleep-related breathing disorder is an independent risk factor for uncontrolled hypertension. J. Hypertens. 2000 Jun;18 (6):679-85.Lavie P., Hoffstein V. Sleep apnea syndrome: a possible contributing factor to resistant. Sleep. 2001 Sep 15;24 (6):721-5.Logan A.G., Perlikowski S.M., Mente A. et al. High prevalence of unrecognized sleep apnoea in drug-resistant hypertension. J. Hypertens. 2001 Dec;19 (12):2271-7.Pedrosa R.P., Drager L.F., Gonzaga C.C. et al. Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension. Hypertension. 2011 Nov;58 (5):811-7. DOI: 10.1161/HYPERTENSIONAHA.111.179788.Wolf J., Narkiewicz K. Optimizing the management of uncontrolled/resistant hypertension. The importance of sleep apnoea syndrome. Curr Vasc Pharmacol. 2017 Apr 14. DOI: 10.2174/15701611 1 566617041411 5705.Somers V.K., Dyken M.E., Mark A.L., Abboud F.M. Sympathetic-nerve activity during sleep in normal subjects. N. Engl J. Med. 1993 Feb 4;328 (5):303-7.Trinder J., Kleiman J., Carrington M. et al. Autonomic activity during human sleep as a function of time and sleep stage. J. Sleep Res. 2001 Dec;10 (4):253-64.Baguet J.P., Narkiewicz K., Mallion J.M. Update on Hypertension Management: obstructive sleep apnea and hypertension. J. Hypertens. 2006 Jan;24 (1):205-8.Ziegler M.G., Milic M. Sympathetic nerves and hypertension in stress, sleep apnea, and caregiving. Curr Opin Nephrol Hypertens. 2017 Jan;26 (1):26-30.Loredo J.S., Clausen J.L., Nelesen R.A. et al. Obstructive sleep apnea and hypertension: are peripheral chemoreceptors involved? Med Hypotheses. 2001 Jan;56 (1):17-9.McEvoy R.D. Obstructive sleep apnoea and hypertension: the ESADA study. Eur Respir J. 2014 Oct;44 (4):835-8. DOI: 10.1183/09031936.00129614.Lee S.A., Amis T.C., Byth K. et al. Heavy snoring as a cause of carotid artery atherosclerosis. Sleep. 2008 Sep;31 (9):1207-13.Schöbel C., Fietze I., Glos M. et al. Nocturnal snoring decreases daytime baroreceptor sensitivity. Respir Med. 2014 Jul;108 (7):1049-55. DOI: 10.1016/j.rmed.2014.03.012.Narkiewicz K., Somers V.K. Sympathetic nerve activity in obstructive sleep apnoea. Acta Physiol Scand. 2003 Mar;177 (3):385-90.Spaak J., Egri Z.J., Kubo T. et al. Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea. Hypertension. 2005 Dec;46 (6):1327-32.Carlson J.T., Hedner J., Elam M. et al. Augmented resting sympathetic activity in awake patients with obstructive sleep apnea. Chest. 1993 Jun;103 (6):1763-8.Jin Z.N., Wei Y.X. Meta-analysis of effects of obstructive sleep apnea on the renin-angiotensin-aldosterone system. J. Geriatr Cardiol. 2016 May;13 (4):333-43. DOI: 10.1 1909/j.issn.1671-541 1.2016.03.020.Möller D.S., Lind P., Strunge B., Pedersen E.B. Abnormal vasoactive hormones and 24-hour blood pressure in obstructive sleep apnea. Am J. Hypertens. 2003 Apr;16 (4):274-80.Di Murro A., Petramala L., Cotesta D. et al. Renin-angiotensin-aldosterone system in patients with sleep apnoea: prevalence of primary aldosteronism. J. Renin Angiotensin Aldosterone Syst. 2010 Sep;11 (3):165-72. DOI: 10.1177/1470320310366581.Calhoun D.A., Nishizaka M.K., Zaman M.A., Harding S.M. Aldosterone excretion among subjects with resistant hypertension and symptoms of sleep apnea. Chest. 2004 Jan;125 (1):112-7.Sim J.J., Yan E.H., Liu I.L. et al. Positive relationship of sleep apnea to hyperaldosteronism in an ethnically diverse population. J. Hypertens. 2011 Aug;29 (8):1 553-9. DOI: 10.1097/HJH.0b013e3283492219.Gonzaga C.C., Gaddam K.K., Ahmed M.I. et al. Severity of obstructive sleep apnea is related to aldosterone status in subjects with resistant hypertension. J. Clin Sleep Med. 2010 Aug 15;6 (4):363-8.Pratt-Ubunama M.N., Nishizaka M.K., Boedefeld R.L. et al. Plasma aldosterone is related to severity of obstructive sleep apnea in subjects with resistant hypertension. Chest. 2007 Feb;131 (2):453-9.Pimenta E., Calhoun D.A., Oparil S. Sleep apnea, aldosterone, and resistant hypertension. Prog Cardiovasc Dis. 2009 Mar-Apr;51 (5):371-80. DOI: 10.1016/j.pcad.2008.02.004.Ke X., Guo W., Peng H. et al. Association of aldosterone excess and apnea-hypopnea index in patients with resistant hypertension. Sci Rep. 2017 Mar 22;7:45241. DOI: 10.1038/srep45241.Kasai T., Motwani S.S., Yumino D. et al. Differing relationship of nocturnal fluid shifts to sleep apnea in men and women with heart failure. Circ Heart Fail. 2012 Jul 1;5 (4):467-74. DOI: 10.1161/CIRCHEARTFAILURE.1 11.965814.Friedman O., Bradley T.D., Chan C.T. et al. Relationship between overnight rostral fluid shift and obstructive sleep apnea in drug-resistant hypertension. Hypertension. 2010 Dec;56 (6):1077-82. DOI: 10.1161/HYPERTENSIONAHA.110.154427.White L.H., Bradley T.D. Role of nocturnal rostral fluid shift in the pathogenesis of obstructive and central sleep apnoea. J. Physiol. 2013 Mar 1;591 (5):1 179-93. DOI: 10.1113/jphysiol.2012.2451 59.Friedman O., Bradley T.D., Logan A.G. Influence of lower body positive pressure on upper airway cross-sectional area in drug-resistant hypertension. Hypertension. 2013 Jan;61 (1):240-5. DOI: 10.1161/HYPERTENSIONAHA.112.203547.Stoohs R., Guilleminault C. Cardiovascular changes associated with obstructive sleep apnea syndrome. J. Appl Physiol (1985). 1992 Feb;72 (2):583-9.Parati G., Lombardi C., Hedner J., Bonsignore M.R., Grote L., Tkacova R., Levy P., Riha R., Bassetti C., Narkiewicz K., Mancia G., McNicholas W.T.; European Respiratory Society; EU COST ACTION B26 members. Position paper on the management of patients with obstructive sleep apnea and hypertension: joint recommendations by the European Society of Hypertension, by the European Respiratory Society and by the members of European COST (COoperation in Scientific and Technological research) ACTION B26 on obstructive sleep apnea. J. Hypertens. 2012 Apr;30(4):633-46. DOI: 10.1097/HJH.0b013e328350e53b.Kita H., Ohi M., Chin K. et al. The nocturnal secretion of cardiac natriuretic peptides during obstructive sleep apnoea and its response to therapy with nasal continuous positive airway pressure. J. Sleep Res. 1998 Sep;7 (3):199-207.Ziegler M.G., Milic M., Sun P. Antihypertensive therapy for patients with obstructive sleep apnea. Curr Opin Nephrol Hypertens. 2011 Jan;20 (1):50-5. DOI: 10.1097/MNH.0b013e3283402eb5.Schulz R., Mahmoudi S., Hattar K. et al. Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy. Am J Respir Crit Care Med. 2000 Aug;162 (2 Pt 1):566-70.Suzuki Y.J., Jain V., Park A.M., Day R.M. Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases. Free Radic Biol Med. 2006 May 15;40 (10):1683-92.Lavie L. Obstructive sleep apnoea syndrome-an oxidative stress disorder. Sleep Med Rev. 2003 Feb;7 (1):35-51.Kato M., Roberts-Thomson P., Phillips B.G. et al. Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea. Circulation. 2000 Nov 21;102 (21):2607-10.Kourembanas S., Marsden P.A., McQuillan L.P., Faller D.V. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J Clin Invest. 1991 Sep;88 (3):1054-7.Phillips B.G., Narkiewicz K., Pesek C.A. et al. Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens. 1999 Jan;17(1):61-6.Prabhakar N.R. Sleep apneas: an oxidative stress? Am J Respir Crit Care Med. 2002 Apr 1;165 (7):859-60.Christou K., Markoulis N., Moulas A.N. et al. Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients. Sleep Breath. 2003 Sep;7 (3):105-10.Ohga E., Tomita T., Wada H. et al. Effects of obstructive sleep apnea on circulating I CAM-1, IL-8, and MCP-1. J Appl Physiol (1985). 2003 Jan;94 (1):179-84.Punjabi N.M., Beamer B.A. C-reactive protein is associated with sleep disordered breathing independent of adiposity. Sleep. 2007 Jan;30 (1):29-34.Dyugovskaya L., Lavie P., Lavie L. Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med. 2002 Apr 1;165 (7):934-9.de la Pena M., Barcelo A., Barbe F. et al. Endothelial function and circulating endothelial progenitor cells in patients with sleep apnea syndrome. Respiration. 2008;76 (1):28-32.Chung S., Yoon I.Y., Shin Y.K. et al. Endothelial dysfunction and C-reactive protein in relation with the severity of obstructive sleep apnea syndrome. Sleep. 2007 Aug;30 (8):997-1001.Ip M.S., Tse H.F., Lam B., Tsang K.W., Lam W.K. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med. 2004 Feb 1;169 (3):348-53. DOI: 10.1164/rccm.200306-767OC.Büchner N.J., Quack I., Woznowski M. et al. Microvascular endothelial dysfunction in obstructive sleep apnea is caused by oxidative stress and improved by continuous positive airway pressure therapy. Respiration. 2011 ;82 (5):409-17. DOI: 10.1 159/000323266.Drager L.F., Polotsky V.Y., Lorenzi-Filho G. Obstructive sleep apnea: an emerging risk factor for atherosclerosis. Chest. 2011 Aug;140 (2):534-542. DOI: 10.1378/chest.10-2223.Tuleta I., Pabst S., Juergens U.R., Nickenig G., Skowasch D. Obstructive sleep apnoea as a risk factor for atherosclerosis -implication for preventive and personalised treatment. EPMA J. 2011 Mar; 2(1):39-47. DOI 10.1007/s13167-01 1-0070-5.Buchner N.J., Quack I., Stegbauer J. et al. Woznowski M, Kaufmann A, Rump LC. Treatment of obstructive sleep apnea reduces arterial stiffness. Sleep Breath. 2012 Mar;16 (1):123-33. DOI 10.1007/s1 1325-010-0465-x.Aziz F., Chaudhary K. The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology. Cardiorenal Med. 2016 Nov;7 (1):74-82. DOI: 10.1 159/000450796.Kraus M.A., Hamburger R.J. Sleep apnea in renal failure. Adv Perit Dial. 1997;13:88-92.Unruh M.L. Sleep apnea and dialysis therapies: things that go bump in the night? Hemodial Int. 2007 Oct;11 (4):369-78.Molnar M.Z., Mucsi I., Novak M. et al. Association of incident obstructive sleep apnoea with outcomes in a large cohort of US veterans. Thorax. 2015 Sep;70 (9):888-95. DOI: 10.1136/thoraxjnl-201 5-206970.Lee Y.C., Hung S.Y., Wang H.K. et al. Sleep apnea and the risk of chronic kidney disease: a nationwide population-based cohort study. Sleep. 2015 Feb 1;38 (2):213-21. DOI: 10.5665/sleep.4400.Markou N., Kanakaki M., Myrianthefs P. et al. Sleep-disordered breathing in nondialyzed patients with chronic renal failure. Lung. 2006 Jan-Feb;184 (1):43-9.Faulx M.D., Storfer-Isser A., Kirchner H.L. et al. Obstructive sleep apnea is associated with increased urinary albumin excretion. Sleep. 2007 Jul;30 (7):923-9.Tsioufis C., Thomopoulos C., Dimitriadis K. et al. Association of obstructive sleep apnea with urinary albumin excretion in essential hypertension: a cross-sectional study. Am J Kidney Dis. 2008 Aug;52 (2):285-93. DOI: 10.1053/j.ajkd.2008.05.001.Sklar A.H., Chaudhary B.A. Reversible proteinuria in obstructive sleep apnea syndrome. Arch Intern Med. 1988 Jan;148 (1):87-9.Campese V.M., Mitra N., Sandee D. Hypertension in renal parenchymal disease: why is it so resistant to treatment? Kidney Int. 2006 Mar;69(6):967-73.Baguet J.P., Hammer L., Lévy P. et al. Night-time and diastolic hypertension are common and underestimated conditions in newly diagnosed apnoeic patients. J Hypertens. 2005 Mar;23 (3):521-7.Grote L., Hedner J., Peter J.H. Mean blood pressure, pulse pressure and grade of hypertension in untreated hypertensive patients with sleep-related breathing disorder. J Hypertens. 2001 Apr;19 (4):683-90.Sharabi Y., Scope A., Chorney N. et al. Diastolic blood pressure is the first to rise in association with early subclinical obstructive sleep apnea: lessons from periodic examination screening. Am J Hypertens. 2003 Mar;16 (3):236-9.Hla K.M., Young T.B., Bidwell T. et al. Sleep apnea and hypertension. A population-based study. Ann Intern Med. 1994 Mar 1;120 (5):382-8.Narkiewicz K., Montano N., Cogliati C. et al. Altered cardiovascular variability in obstructive sleep apnea. Circulation. 1998 Sep 15;98 (11):1071-7.Portaluppi F.1., Provini F., Cortelli P. et al. Undiagnosed sleep-disordered breathing among male nondippers with essential hypertension. J Hypertens. 1997 Nov;15 (1 1):1227-33.Tsioufis C., Kasiakogias A., Thomopoulos C. et al. Managing hypertension in obstructive sleep apnea: the interplay of continuous positive airway pressure, medication and chronotherapy. J Hypertens. 2010 May;28 (5):875-82. DOI: 10.1097/ HJH.0b013e328336ed85.Noda A., Okada T., Hayashi H. et al. 24-hour ambulatory blood pressure variability in obstructive sleep apnea syndrome. Chest. 1993 May;103 (5):1343-7.Loredo J.S., Ancoli-Israel S., Dimsdale J.E. Sleep quality and blood pressure dipping in obstructive sleep apnea. Am J Hypertens. 2001 Sep;14 (9 Pt 1):887-92.Tsioufis C., Andrikou I., Thomopoulos C. et al. Increased nighttime blood pressure or nondipping profile for prediction of cardiovascular outcomes. J Hum Hypertens. 2011 May;25 (5):281-93. DOI: 10.1038/jhh.2010.113.Kario K., Pickering T.G., Umeda Y. et al. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study. Circulation. 2003 Mar 18;107 (10):1401-6.Henskens L.H., Kroon A.A., van Oostenbrugge R.J. et al. Associations of ambulatory blood pressure levels with white matter hyperintensity volumes in hypertensive patients. J Hypertens. 2009 Jul;27 (7):1446-52. DOI: 10.1097/HJH.0b013e32832b5204.Perez-Lloret S., Toblli J.E., Cardinali D.P. et al. Nocturnal hypertension defined by fixed cut-off limits is a better predictor of left ventricular hypertrophy than non-dipping. Int J Cardiol. 2008 Jul 21;127 (3):387-9.Gonçalves S.C., Martinez D., Gus M. et al. Obstructive sleep apnea and resistant hypertension: a case-control study. Chest. 2007 Dec;132 (6):1858-62.Parati G., Lombardi C., Hedner J. et al. Recommendations for the management of patients with obstructive sleep apnoea and hypertension. Eur Respir J. 2013 Mar;41 (3):523-38. DOI: 10.1 183/09031936.00226711.Grigg-Damberger M.M. The AASM Scoring Manual four years later. J Clin Sleep Med. 2012 Jun 15;8 (3):323-32. DOI: 10.5664/ jcsm.1928.Abrishami A., Khajehdehi A., Chung F. A systematic review of screening questionnaires for obstructive sleep apnea. Can J Anaesth. 2010 May;57 (5):423-38. DOI: 10.1007/s12630-010-9280-x.Buysse D.J., Young T., Edinger J.D. et al. Clinicians' use of the International Classification of Sleep Disorders: results of a national survey. Sleep. 2003 Feb 1;26 (1):48-51.Camargo S., Riedl M., Anteneodo C. et al. Sleep apnea-hypopnea quantification by cardiovascular data analysis. PLoS One. 2014 Sep 15;9 (9):e107581. DOI: 10.1371/journal.pone.0107581.Johansson K., Hemmingsson E., Harlid R. et al. Longer term effects of very low energy diet on obstructive sleep apnoea in cohort derived from randomised controlled trial: prospective observational follow-up study. BMJ. 2011 Jun 1;342:d3017. DOI: 10.1136/bmj.d3017.Pannain S., Mokhlesi B. Bariatric surgery and its impact on sleep architecture, sleep-disordered breathing, and metabolism. Best Pract Res Clin Endocrinol Metab. 2010 Oct;24 (5):745-61. DOI: 10.1016/j.beem.2010.07.007.Yee B.J., Phillips C.L., Banerjee D. et al. The effect of sibutramine-assisted weight loss in men with obstructive sleep apnoea. Int J Obes (Lond). 2007 Jan;31 (1):161-8.Maki-Nunes C., Toschi-Dias E., Cepeda F.X. et al. Diet and exercise improve chemoreflex sensitivity in patients with metabolic syndrome and obstructive sleep apnea. Obesity (Silver Spring). 2015 Aug;23 (8):1 582-90. DOI: 10.1002/oby.21126.Chirinos J.A., Gurubhagavatula I., Teff K. et al. CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med. 2014 Jun 12;370 (24):2265-75. DOI: 10.1056/NEJMoa1306187.de Souza F., Muxfeldt E., Fiszman R., Salles G. Efficacy of spironolactone therapy in patients with true resistant hypertension. Hypertension. 2010 Jan;55 (1):147-52. DOI: 10.1161/HYPERTENSIONAHA.109.140988.Williams B., MacDonald T.M., Morant S. et al. Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet. 2015 Nov 21;386 (10008):2059-2068. DOI: 10.1016/S0140-6736(15)00257-3.Pelttari L.H., Hietanen E.K., Salo T.T. et al. Little effect of ordinary antihypertensive therapy on nocturnal high blood pressure in patients with sleep disordered breathing. Am J Hypertens. 1998 Mar;11 (3 Pt 1):272-9.Furlan S.F., Braz C.V., Lorenzi-Filho G., Drager L.F. Management of Hypertension in Obstructive Sleep Apnea. Curr Cardiol Rep. 2015 Dec;17 (12):108. DOI: 10.1007/s11886-015-0663-z.Weichler U., Herres-Mayer B., Mayer J. et al. Influence of antihypertensive drug therapy on sleep pattern and sleep apnea activity. Cardiology. 1991;78 (2):124-30.Kraiczi H., Hedner J., Peker Y., Grote L. Comparison of atenolol, amlodipine, enalapril, hydrochlorothiazide, and losartan for antihypertensive treatment in patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2000 May;161 (5):1423-8.Ziegler M.G., Milic M., Lu X. et al. Effect of obstructive sleep apnea on the response to hypertension therapy. Clin Exp Hypertens. 2017;39 (5):409-415. DOI: 10.1080/10641963.2016.1259327.Zou D., Grote L., Eder D.N. et al. A double-blind, crossover study of Doxazosin and Enalapril on peripheral vascular tone and nocturnal blood pressure in sleep apnea patients. Sleep Med. 2010 Mar;1 1 (3):325-8. DOI: 10.1016/j.sleep.2009.10.004.Taylor S.H., Lee P.S., Sharma S.K. A comparison of doxazosin and enalapril in the treatment of mild and moderate essential hypertension. Am Heart J. 1988 Dec;116 (6 Pt 2):1820-5.Ebbs D. A comparison of selected antihypertensives and the use of conventional vs ambulatory blood pressure in the detection and treatment of hypertension. Cardiology. 2001;96 Suppl 1:3-9.Planés C., Foucher A., Leroy M. et al. Effect of celiprolol treatment in hypertensive patients with sleep apnea. Sleep. 1999 Jun 15;22 (4):507-13.Mayer J., Weichler U., Herres-Mayer B. et al. Influence of metoprolol and cilazapril on blood pressure and on sleep apnea activity. J Cardiovasc Pharmacol. 1990 Dec;16 (6):952-61.Grote L., Heitmann J., Schneider H. et al. Twenty-four-hour blood pressure control: effect of cilazapril on continuous arterial blood pressure during sleep, and physical and mental load in patients with arterial hypertension and sleep apnea. J Cardiovasc Pharmacol. 1994;24 Suppl 3:S78-82.Heitmann J., Greulich T., Reinke C. et al. Comparison of the effects of nebivolol and valsartan on BP reduction and sleep apnoea activity in patients with essential hypertension and OSA. Curr Med Res Opin. 2010 Aug;26 (8):1925-32. DOI: 10.1 185/03007995.2010.497326.Thunström E., Manhem K., Rosengren A., Peker Y. Blood Pressure Response to Losartan and Continuous Positive Airway Pressure in Hypertension and Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2016 Feb 1;193 (3):310-20. DOI: 10.1164/ rccm.201 505-0998OC.Cicolin A., Mangiardi L., Mutani R., Bucca C. Angiotensin-converting enzyme inhibitors and obstructive sleep apnea. Mayo Clin Proc. 2006 Jan;81 (1):53-5.Kohler M., Stradling J.R. Mechanisms of vascular damage in obstructive sleep apnea. Nat Rev Cardiol. 2010 Dec;7 (12):677-85. DOI: 10.1038/nrcardio.2010.145.Kasai T., Bradley T.D., Friedman O., Logan A.G. Effect of intensified diuretic therapy on overnight rostral fluid shift and obstructive sleep apnoea in patients with uncontrolled hypertension. J Hypertens. 2014 Mar;32 (3):673-80. DOI: 10.1097/ HJH.0000000000000047.Yang L., Zhang H., Cai M. et al. Effect of spironolactone on patients with resistant hypertension and obstructive sleep apnea. Clin Exp Hypertens. 2016;38 (5):464-8. DOI: 10.3109/10641963.2015.1131290.Khurshid K., Yabes J., Weiss P.M. et al. Effect of Antihypertensive Medications on the Severity of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis. J Clin Sleep Med. 2016 Aug 15;12 (8):1143-51. DOI: 10.5664/jcsm.6054.Krasinska B., Miazga A., Cofta S. et al. Effect of eplerenone on the severity of obstructive sleep apnea and arterial stiffness in patients with resistant arterial hypertension. Pol Arch Med Wewn. 2016 May 27;126 (5):330-9. DOI: 10.20452/pamw.3410.Nerbass F.B., Pedrosa R.P., Genta P.R. et al. Calcium channel blockers are independently associated with short sleep duration in hypertensive patients with obstructive sleep apnea. J Hypertens. 2011 Jun;29 (6):1236-41. doi: 10.1097/ HJH.0b013e3283462e8b.Ruttanaumpawan P., Nopmaneejumruslers C., Logan A.G. et al. Association between refractory hypertension and obstructive sleep apnea. J Hypertens. 2009 Jul;27 (7):1439-45. DOI: 10.1097/HJH.0b013e32832af679.Kennedy T., Summer W. Inhibition of hypoxic pulmonary vasoconstriction by nifedipine. Am J Cardiol. 1982 Oct;50 (4):864-8.Hansen T.W., Li Y., Boggia J. et al. Predictive role of the nighttime blood pressure. Hypertension. 2011 Jan;57 (1):3-10. DOI: 10.1161/HYPERTENSIONAHA.109.133900.Kasiakogias A., Tsioufis C., Thomopoulos C. et al. Evening versus morning dosing of antihypertensive drugs in hypertensive patients with sleep apnoea: a cross-over study. J Hypertens. 2015 Feb;33 (2):393-400. DOI: 10.1097/HJH.0000000000000371.Hermida R.C., Ayala D.E., Fernandez J.R., Calvo C. Chronotherapy improves blood pressure control and reverts the nondipper pattern in patients with resistant hypertension. Hypertension. 2008 Jan;51 (1):69-76.Diogo L.N., Monteiro E.C. The efficacy of antihypertensive drugs in chronic intermittent hypoxia conditions. Front Physiol. 2014 Sep 22;5:361.Torres G., Sánchez-de-la-Torre M., Barbé F. Relationship Between OSA and Hypertension. Chest. 2015 Sep;148 (3):824-832. DOI: 10.1378/chest.15-0136.Bhatt D.L., Kandzari D.E., O'Neill W.W. et al. A controlled trial of renal denervation for resistant hypertension. N Engl J Med. 2014 Apr 10;370 (15):1393-401. DOI: 10.1056/NEJMoa1402670.Kario K., Bhatt D.L., Kandzari D.E. et al. Impact of Renal Denervation on Patients With Obstructive Sleep Apnea and Resistant Hypertension- Insights From the SYMPLICITY HTN-3 Trial. Circ J. 2016 May 25;80 (6):1404-12. DOI: 10.1253/circj. CJ-16-0035.Witkowski A., Prejbisz A., Florczak E. et al. Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea. Hypertension. 2011 Oct;58 (4):559-65. DOI: 10.1161/HYPERTENSIONAHA.111.173799.Shantha G.P., Pancholy S.B. Effect of renal sympathetic denervation on apnea-hypopnea index in patients with obstructive sleep apnea: a systematic review and meta-analysis. Sleep Breath. 2015 Mar;19 (1):29-34. DOI: 10.1007/s1 1325-014-0991-z.Townsend R.R., Mahfoud F., Kandzari D.E. et al. Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial. The Lancet. 2017 Nov; 390(10108):2160-70. DOI: http://dx.doi.org/10.1016/S0140-6736(17)32281-XFengler K., Ewen S., Hollriegel R. et al. Blood Pressure Response to Main Renal Artery and Combined Main Renal Artery Plus Branch Renal Denervation in Patients With Resistant Hypertension. J Am Heart Assoc. 2017;6:e006196. DOI: 1161/ JAHA.117.006196.Sullivan C.E., Issa F.G., Berthon-Jones M., Eves L. Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet. 1981 Apr 18;1 (8225):862-5.Lewis E.F., Wang R., Punjabi N. et al. Impact of continuous positive airway pressure and oxygen on health status in patients with coronary heart disease, cardiovascular risk factors, and obstructive sleep apnea: A Heart Biomarker Evaluation in Apnea Treatment (HEARTBEAT) analysis. Am Heart J. 2017 Jul;189:59-67. DOI: 10.1016/j.ahj.2017.03.001.Pepperell J.C., Ramdassingh-Dow S., Crosthwaite N. et al. Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial. Lancet. 2002 Jan 19;359 (9302):204-10.Drager L.F., Bortolotto L.A., Figueiredo A.C. et al. Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med. 2007 Oct 1;176 (7):706-12.Kasiakogias A., Tsioufis C., Thomopoulos C. et al. Effects of continuous positive airway pressure on blood pressure in hypertensive patients with obstructive sleep apnea: a 3-year follow-up. J Hypertens. 2013 Feb;31 (2):352-60. DOI: 10.1097/ HJH.0b013e32835bdcda.Giles T.L., Lasserson T.J., Smith B.J. et al. Continuous positive airways pressure for obstructive sleep apnoea in adults. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD001 106.Feldstein C.A. Blood pressure effects of CPAP in nonresistant and resistant hypertension associated with OSA: A systematic review of randomized clinical trials. Clin Exp Hypertens. 2016;38 (4):337-46. DOI: 10.3109/10641963.2016.11481 56.Parati G., Lombardi C. Control of hypertension in nonsleepy patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2010 Apr 1;181 (7):650-2. DOI: 10.1164/rccm.201001-0031ED.Hu X., Fan J., Chen S. et al. The role of continuous positive airway pressure in blood pressure control for patients with obstructive sleep apnea and hypertension: a meta-analysis of randomized controlled trials. J Clin Hypertens (Greenwich). 2015 Mar;17 (3):215-22. DOI: 10.1111/jch.12472.Fava C., Dorigoni S., Dalle Vedove F. et al. Effect of CPAP on blood pressure in patients with OSA/hypopnea a systematic review and meta-analysis. Chest. 2014 Apr;145 (4):762-771. DOI: 10.1378/chest.13-1115.Montesi S.B., Edwards B.A., Malhotra A., Bakker J.P. The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med. 2012 Oct 15;8 (5):587-96. DOI: 10.5664/jcsm.2170.Bratton D.J., Strádling J.R., Barbé F., Kohler M. Effect of CPAP on blood pressure in patients with minimally symptomatic obstructive sleep apnoea: a meta-analysis using individual patient data from four randomised controlled trials. Thorax. 2014 Dec;69 (12):1128-35. doi: 10.1136/thoraxjnl-2013-204993.Bakker J.P., Edwards B.A., Gautam S.P. et al. Blood pressure improvement with continuous positive airway pressure is independent of obstructive sleep apnea severity. J Clin Sleep Med. 2014 Apr 15;10 (4):365-9. DOI: 10.5664/jcsm.3604.Denker M.G., Cohen D.L. Use of continuous positive airway pressure for sleep apnea in the treatment of hypertension. Curr Opin Nephrol Hypertens. 2014 Sep;23 (5):462-7. DOI: 10.1097/MNH.0000000000000047.Durán-Cantolla J., Aizpuru F., Martínez-Null C., Barbé-Illa F. Obstructive sleep apnea/hypopnea and systemic hypertension. Sleep Med Rev. 2009 Oct;13 (5):323-31. DOI: 10.1016/j.smrv.2008.1 1.001.Schwarz E.I., Schlatzer C., Rossi V.A. et al. Effect of CPAP Withdrawal on BP in OSA: Data from Three Randomized Controlled Trials. Chest. 2016 Dec;1 50 (6):1202-1210. DOI: 10.1016/j.chest.2016.07.012.Lozano L., Tovar J.L., Sampol G. et al. Continuous positive airway pressure treatment in sleep apnea patients with resistant hypertension: a randomized, controlled trial. J Hypertens. 2010 Oct;28 (10):2161-8. DOI: 10.1097/HJH.0b013e32833b9c63.Martínez-García M.A., Capote F., Campos-Rodríguez F. et al. Effect of CPAP on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the HIPARCO randomized clinical trial. JAMA. 2013 Dec 11;310 (22):2407-15. DOI: 10.1001/jama.2013.281250.Pedrosa R.P., Drager L.F., de Paula L.K.G. et al. Effects of OSA treatment on BP in patients with resistant hypertension: a randomized trial. Chest. 2013 Nov;144 (5):1487-1494. DOI: 10.1378/chest.13-0085.de Oliveira A.C., Martinez D., Massierer D. et al. The antihypertensive effect of positive airway pressure on resistant hypertension of patients with obstructive sleep apnea: a randomized, double-blind, clinical trial. Am J Respir Crit Care Med. 2014 Aug 1;190 (3):345-7. doi: 10.1164/rccm.201403-0479LE.Muxfeldt E.S., Margallo V., Costa L.M. et al. Effects of continuous positive airway pressure treatment on clinic and ambulatory blood pressures in patients with obstructive sleep apnea and resistant hypertension: a randomized controlled trial. Hypertension. 2015 Apr;65 (4):736-42. DOI: 10.1161/HYPERTENSIONAHA.114.04852.Iftikhar I.H., Valentine C.W., Bittencourt L.R. et al. Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis. J Hypertens. 2014 Dec;32 (12):2341-50; discussion 2350. DOI: 10.1097/HJH.0000000000000372.Kario K., Kuwabara M., Hoshide S. et al. Effects of nighttime single-dose administration of vasodilating vs sympatholytic antihypertensive agents on sleep blood pressure in hypertensive patients with sleep apnea syndrome. J Clin Hypertens (Greenwich). 2014 Jun;16 (6):459-66. DOI: 10.1111/jch.12327.Gay P., Weaver T., Loube D., Iber C. Evaluation of positive airway pressure treatment for sleep related breathing disorders in adults. Sleep. 2006 Mar;29 (3):381-401.Ziegler M.G., Mills P.J., Loredo J.S. et al. Effect of continuous positive airway pressure and placebo treatment on sympathetic nervous activity in patients with obstructive sleep apnea. Chest. 2001 Sep;120 (3):887-93.Heitmann J., Ehlenz K., Penzel T. et al. Sympathetic activity is reduced by nCPAP in hypertensive obstructive sleep apnoea patients. Eur Respir J. 2004 Feb;23 (2):255-62.Tamisier R., Tan C.O., Pepin J.L. et al. Blood Pressure Increases in OSA due to Maintained Neurovascular Sympathetic Transduction: Impact of CPAP. Sleep. 2015 Dec 1;38 (12):1973-80. DOI: 10.5665/sleep.5252.Yorgun H., Kabakçi G., Canpolat U. et al. (2014). Predictors of blood pressure reduction with nocturnal continuous positive airway pressure therapy in patients with obstructive sleep apnea and prehypertension. Angiology. 2014 Feb;65 (2):98-103. DOI: 10.1177/0003319713477908.Panoutsopoulos A., Kallianos A., Kostopoulos K. et al. Effect of CPAP treatment on endothelial function and plasma CRP levels in patients with sleep apnea. Med Sci Monit. 2012 Dec;18 (12):CR747-51.de Souza F., Muxfeldt E.S., Margallo V. et al. Effects of continuous positive airway pressure treatment on aldosterone excretion in patients with obstructive sleep apnoea and resistant hypertension: a randomized controlled trial. J Hypertens. 2017 Apr;35 (4):837-844. DOI: 10.1097/HJH.0000000000001254.Marshall N.S., Wong K.K., Liu P.Y. et al. Sleep apnea as an independent risk factor for all-cause mortality: the Busselton Health Study. Sleep. 2008 Aug;31 (8):1079-85.Ge X., Han F., Huang Y. et al. Is obstructive sleep apnea associated with cardiovascular and all-cause mortality? PLoS One. 2013 Jul 25;8 (7):e69432. DOI: 10.1371/journal.pone.0069432.Mokhlesi B., Ayas N.T. Cardiovascular Events in Obstructive Sleep Apnea - Can CPAP Therapy SAVE Lives? N Engl J Med. 2016 Sep 8;375 (10):994-6. doi: 10.1056/NEJMe1609704.Sekizuka H., Osada N., Akashi Y.J. Effect of oral appliance therapy on blood pressure in Japanese patients with obstructive sleep apnea. Clin Exp Hypertens. 2016;38 (4):404-8. DOI: 10.3109/10641963.2016.1148159.Andren A., Hedberg P., Walker-Engström M.L. et al. Effects of treatment with oral appliance on 24-h blood pressure in patients with obstructive sleep apnea and hypertension: a randomized clinical trial. Sleep Breath. 2013 May;17 (2):705-12. DOI: 10.1007/s1 1325-012-0746-7.Phillips C.L., Grunstein R.R., Darendeliler M.A. et al. Health outcomes of continuous positive airway pressure versus oral appliance treatment for obstructive sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med. 2013 Apr 15;187 (8):879-87. DOI: 10.1164/rccm.201212-2223OC.Iftikhar I.H., Hays E.R., Iverson M.A. et al. Effect of oral appliances on blood pressure in obstructive sleep apnea: a systematic review and meta-analysis. J Clin Sleep Med. 2013 Feb 1;9 (2):165-74. DOI: 10.5664/jcsm.2420.