TherapyTherapyТерапия2412-40362713-1823Bionika Media279260ArticlesСтатьиReview ArticleCerebrovascular disease: Pharmacological properties and efficacy of dipiridamol as a medicament with pleiotropic action mechanismЦереброваскулярная болезнь: фармакологические свойства и эффективность дипиридамола как препарата с плейотропным механизмом действияCheltsovVictor V.ЧельцовВиктор Владимирович

MD, professor of the Department of general and clinical pharmacology, Мedical Institute

д.м.н., профессор кафедры общей и клинической фармакологии Медицинский институт

vcheltsov@mail.ruMartynovAnatoly I.МартыновАнатолий Иванович

MD, professor, academician of RAS, professor of the Department of hospital therapy № 1, A.I. Yevdokimov Moscow state university of medicine and dentistry of the Ministry of Health of Russia, president of Russian scientific society of physicians, honoured scientist of the Russian Federation, honoured doctor of the Russian Federation, laureate of the USSR government prize

д.м.н., профессор, академик РАН, профессор кафедры госпитальной терапии № 1 президент РНМОТ, заслуженный деятель науки РФ, заслуженный врач РФ, лауреат премии Правительства СССР

Federal State Autonomous Educational Institution «People's Friendship University of Russia»ФГАОУ ВО «Российский Университет дружбы народов»A.I. Yevdokimov Moscow state university of medicine and dentistry of the Ministry of Health of RussiaФГБОУ ВО «МГМСУ им. А.И. Евдокимова» Минздрава России150120181NO1 (2018)№1 (2018)879524022023Copyright ©; 2018, “Bionika Media” LLCCopyright ©; 2018, ООО «Бионика Медиа»2018“Bionika Media” LLCООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/about/editorialPolicieshttps://journals.eco-vector.com/2412-4036/article/view/279260

Main clinical-pharmacological effects of dipiridamol action are considered in the context of its use in case of cerebrovascular disease. The vasodilatating effect of the medicine, antioxidative effect and ability to improve tissue perfusion are accentuated. The results of experimental and clinical research work reflecting efficacy and safety of dipiridamol are introduced. Pleiotropic action mechanism of the medicament whicht makes it possible to have a complex influence at pathogenetic factors of cerebrovascular disease is noted.

Рассмотрены основные клинико-фармакологические эффекты дипиридамола в контексте его применения при цереброваскулярной болезни. Сделан акцент на вазодилатирующем действии препарата, его способности улучшать перфузию тканей и антиоксидантном эффекте. Приведены результаты экспериментальных и клинических исследований, отражающих эффективность и безопасность дипиридамола. Отмечен плейотропный механизм действия препарата, позволяющий достичь комплексного воздействия на патогенетические факторы цереброваскулярной болезни.

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