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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">279273</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">About fundamental and clinical aspects of magnesium and ribolavine synergic action in therapeutic practice</article-title><trans-title-group xml:lang="ru"><trans-title>О фундаментальных и клинических аспектах синергидного действия магния и рибофлавина в терапевтической практике</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gromova</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Громова</surname><given-names>Ольга Алексеевна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, professor, leading scientific worker, head of the pharmacoinformatics laboratory of “Informatics and management"; рrofessor of the Department of Pharmacology</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, в.н.с., зав. лаборатории фармакоинформатики; профессор кафедры фармакологии</p></bio><email>unesco.gromova@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Torshin</surname><given-names>Ivan Ju.</given-names></name><name xml:lang="ru"><surname>Торшин</surname><given-names>Иван Юрьевич</given-names></name></name-alternatives><bio xml:lang="en"><p>cand. of physical and mathematical sciences, senior scientific worker of “Informatics and management"</p></bio><bio xml:lang="ru"><p>к.ф-м.н., с.н.с</p></bio><email>tyu@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kobalava</surname><given-names>Zhanna D.</given-names></name><name xml:lang="ru"><surname>Кобалава</surname><given-names>Жанна Давидовна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, professor, head of the general medicine Department with cardiology and functional diagnostics course, head of the department of general medicine, cardiology and clinical pharmacology of the medical staff advanced training faculty</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, зав. кафедрой внутренних болезней с курсом кардиологии и функциональной диагностики Медицинского института; зав. кафедрой внутренних болезней, кардиологии и клинической фармакологии факультета повышения квалификации медицинских работников Медицинского института</p></bio><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sorokina</surname><given-names>Maria A.</given-names></name><name xml:lang="ru"><surname>Сорокина</surname><given-names>Мария Андреевна</given-names></name></name-alternatives><bio xml:lang="en"><p>medical resident of the general medicine Department of fundamental medicine faculty</p></bio><bio xml:lang="ru"><p>ординатор кафедры внутренних болезней факультета фундаментальной медицины</p></bio><email>info@fbm.msu.ru</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal research center «Informatics and management» of RAS</institution></aff><aff><institution xml:lang="ru">Федеральный исследовательский центр «Информатика и управление» РАН</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Federal State Budgetary Educational Institution of Higher Education «Ivanovo State Medical Academy» of the Ministry of Healthcare of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Ивановская государственная медицинская академия» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Peoples' friendship university of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский университет дружбы народов»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Lomonosov Moscow state university</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2018</year></pub-date><issue>1</issue><issue-title xml:lang="en">NO1 (2018)</issue-title><issue-title xml:lang="ru">№1 (2018)</issue-title><fpage>119</fpage><lpage>131</lpage><history><date date-type="received" iso-8601-date="2023-02-24"><day>24</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, “Bionika Media” LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, ООО «Бионика Медиа»</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">“Bionika Media” LLC</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://journals.eco-vector.com/2412-4036/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/279273">https://journals.eco-vector.com/2412-4036/article/view/279273</self-uri><abstract xml:lang="en"><p>Article consequentially reflects the themes concerning the basis of magnesium and riboflavine pharmacology, prevalence of magnesium and riboflavine deficiencies, perspectives of combined magnesium-and riboflavine-based medicaments use for cardiovascular therapy, diseases with antiinflammatory component, metabolic disorders and migraine.</p></abstract><trans-abstract xml:lang="ru"><p>В статье последовательно рассматриваются основы фармакологии магния и рибофлавина, распространенность дефицитов магния и рибофлавина, перспективы сочетанного использования препаратов магния и рибофлавина в терапии сердечно-сосудистой патологии, заболеваний с провоспалительным компонентом, метаболических расстройств и мигрени.</p></trans-abstract><kwd-group xml:lang="en"><kwd>magnesium citrate</kwd><kwd>riboflavine</kwd><kwd>Magnesol</kwd><kwd>cardiovascular diseases</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>цитрат магния</kwd><kwd>рибофлавин</kwd><kwd>Магнесол</kwd><kwd>сердечно-сосудистые заболевания</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Громова О.А., Калачева А.Г., Торшин И.Ю., Рудаков К.В., Грустливая У.Е., Юдина Н.В., Егорова Е.Ю., Лиманова О.А., Федотова Л.Э., Грачева О.Н., Никифорова Н.В., Сатарина Т.Е., Гоголева И.В., Гришина Т.Р., Курамшина Д.Б., Новикова Л.Б., Лисицына Е.Ю., Керимкулова Н.В., Владимирова И.С., Чекмарева М.Н., Лялякина Е.В., Шалаева Л.А., Талепоровская С.Ю., Силинг Т.Б., Прозорова Н.В., Семенов В.А., Семенова О.В., Назарова Н.А., Галустян А.Н., Сардарян И.С. 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