TherapyTherapyТерапия2412-40362713-1823Bionika Media28876110.18565/therapy.2022.1.71-93ArticlesСтатьиResearch ArticleExtraintestinal manifestations of inflammatory bowel diseases: modern conception and contribution to the disease insightВнекишечные проявления воспалительных заболеваний кишечника: современная концепция и вклад в представление о заболеванииBakulinIgor G.БакулинИгорь Геннадьевич

MD, professor, head of the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss

д.м.н., профессор, зав. кафедрой пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С.М. Рысса

igbakulinr@yandex.ruSkalinskayaMaria I.СкалинскаяМария Игоревна

PhD, associate professor, associate professor of the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss

к.м.н., доцент, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С.М. Рысса

mskalinskaya@yahoo.comSkazyvaevaEkaterina V.СказываеваЕкатерина Васильевна

PhD, associate professor, associate professor of the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss

к.м.н., доцент, доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С.М. Рысса

skazyvaeva@yandex.ruRasmaginaIrina A.РасмагинаИрина Алексеевна

postgraduate student at the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss

аспирант кафедры пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С.М. Рысса

irenerasmagina@gmail.comZhuravlevaMaria S.ЖуравлеваМария Сергеевна

PhD, associate professor of the Department of propaedeutics of internal diseases, gastroenterology and dietology named after S.M. Ryss

к.м.н., доцент кафедры пропедевтики внутренних болезней, гастроэнтерологии и диетологии им. С.М. Рысса

ms_zhuravleva@mail.ruUsachevRoman A.УсачевРоман Алексеевич

student of the Faculty of general medicine

студент лечебного факультета

roman.usachev4@gmail.comI.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of RussiaФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России1501202281VOL 8, NO1 (2022)ТОМ 8, №1 (2022)719326022023Copyright ©; 2022, “Bionika Media” LLCCopyright ©; 2022, ООО «Бионика Медиа»2022“Bionika Media” LLCООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/about/editorialPolicieshttps://journals.eco-vector.com/2412-4036/article/view/288761

Due to the significant influence of the extra-intestinal manifestations on the prognosis and management of patients with inflammatory bowel diseases (IBD), it is relevant to study their pathogenesis, as well as to improve diagnostic and therapeutic approaches. The review article highlights modern international views on the pathogenesis of extra-intestinal manifestations in Crohn's disease and ulcerative colitis and clinical diversity of the affected organs and systems disorders, including the musculoskeletal system, skin, oral cavity, renal, hepatobiliary and ocular systems, lungs and peripheral vessels. Information about the prevalence of the extra-intestinal manifestations in IBD varies. In general, according to the authors from various countries, the highest prevalence of the extraintestinal manifestations was noted in Crohn's disease, in female patients, in smokers, and patients with a longer duration of the disease. According to the modern concepts, extra-intestinal manifestations are considered to be the result of an antigen-specific immune response of the intestine to cells outside of the intestine, or an independent inflammatory event that is initiated as a result of the presence of genetic risk factors and/or environmental risk factors. In the present article the own data of the North-Western IBD Registry from Saint-Petersburg (Russia) on the frequency and features of extra-intestinal manifestations of IBD are represented, analyzed and compared with the world data.

В связи со значительным влиянием внекишечных проявлений на прогноз и тактику ведения пациентов с воспалительными заболеваниями кишечника (ВЗК) актуальным является изучение их патогенеза, а также совершенствование диагностики и терапевтической тактики. В обзорной статье рассмотрены современные мировые представления о патогенезе и клиническом многообразии внекишечных проявлений болезни Крона и язвенного колита, включая поражение опорно-двигательного аппарата, кожи, полости рта, глаз, гепатобилиарной системы, почек, легких и периферических сосудов. Сведения о распространенности внекишечных проявлений при ВЗК разнятся. В целом, по данным авторов различных стран, наибольшая распространенность внекишечных проявлений отмечена при болезни Крона, у пациентов женского пола, у курильщиков и при большей продолжительности заболевания. По современным представлениям, внекишечные проявления считаются результатом антиген-специфического иммунного ответа кишечника на клетки вне кишки либо независимого воспалительного события, которое инициируется в результате наличия генетических факторов риска и/или факторов риска окружающей среды. В статье проанализированы и сопоставлены с мировыми данными собственные данные Регистра 71 Северо-западного центра лечения ВЗК о частоте и особенностях внекишечных проявлений ВЗК.

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