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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">288769</article-id><article-id pub-id-type="doi">10.18565/therapy.2022.1.114-122</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Alirocumab in patients of very high cardiovascular risk</article-title><trans-title-group xml:lang="ru"><trans-title>Применение алирокумаба у пациентов очень высокого сердечно-сосудистого риска</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Boeva</surname><given-names>Olga I.</given-names></name><name xml:lang="ru"><surname>Боева</surname><given-names>Ольга Игоревна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD, DMSci., professor of the Department of therapy, cardiology and functional diagnostics with the course of nephrology</p></bio><bio xml:lang="ru"><p>д.м.н., доцент, профессор кафедры терапии, кардиологии и функциональной диагностики с курсом нефрологии</p></bio><email>box0271@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kokorin</surname><given-names>Valentin A.</given-names></name><name xml:lang="ru"><surname>Кокорин</surname><given-names>Валентин Александрович</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD, DMSci., professor of the Department of hospital therapy</p></bio><bio xml:lang="ru"><p>д.м.н., доцент, профессор кафедры госпитальной терапии</p></bio><email>valentinkokorin@yahoo.com</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central State Medical Academy of the Presidential Executive Office</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Центральная государственная медицинская академия» УД Президента РФ</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2022</year></pub-date><volume>8</volume><issue>1</issue><issue-title xml:lang="en">VOL 8, NO1 (2022)</issue-title><issue-title xml:lang="ru">ТОМ 8, №1 (2022)</issue-title><fpage>114</fpage><lpage>122</lpage><history><date date-type="received" iso-8601-date="2023-02-26"><day>26</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ООО «Бионика Медиа»</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/288769">https://journals.eco-vector.com/2412-4036/article/view/288769</self-uri><abstract xml:lang="en"><p>In the present review, the focus is on the rationale for proprotein convertase subtilisin/ kexin type 9 (PCSK9) inhibitors in the dyslipidemia correction in patients with very high and extreme cardiovascular risk.</p></abstract><trans-abstract xml:lang="ru"><p>В фокусе внимания этой обзорной работы - обоснование применения ингибиторов пропротеиновой конвертазы субтилизина/кексина типа 9 (PCSK9) в коррекции дислипидемии с акцентом на категории больных очень высокого и экстремального сердечно-сосудистого риска.</p></trans-abstract><kwd-group xml:lang="en"><kwd>dyslipidemia</kwd><kwd>high cardiovascular risk</kwd><kwd>lipid-lowering therapy</kwd><kwd>PCSK9 inhibitors</kwd><kwd>alirocumab</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дислипидемия</kwd><kwd>высокий сердечно-сосудистый риск</kwd><kwd>гиполипидемическая терапия</kwd><kwd>ингибиторы PCSK9</kwd><kwd>алирокумаб</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Awan Z., Seidah N.G., MacFadyen J.G. et al. 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