TherapyTherapyТерапия2412-40362713-1823Bionika Media28877910.18565/therapy.2022.1.154-161ArticlesСтатьиResearch ArticleNeurological manifestations of post-covid syndromeНеврологические проявления постковидного синдромаZakharovVladimir V.ЗахаровВладимир Владимирович

MD, professor, professor of the Department of nervous diseases and neurosurgery

д.м.н., профессор, профессор кафедры нервных болезней и нейрохирургии

dariagromova87@gmail.comGromovaDaria O.ГромоваДарья Олеговна

neurologist, senior laboratory assistant at the Department of nervous diseases and neurosurgery

врач-невролог, старший лаборант кафедры нервных болезней и нейрохирургии

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)» Минздрава России1501202281VOL 8, NO1 (2022)ТОМ 8, №1 (2022)15416126022023Copyright ©; 2022, “Bionika Media” LLCCopyright ©; 2022, ООО «Бионика Медиа»2022“Bionika Media” LLCООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/about/editorialPolicieshttps://journals.eco-vector.com/2412-4036/article/view/288779

Post-covid syndrome is one of the new problems that healthcare is faced during the COVID-19 pandemic. According to clinical studies results, up to one third of SARS-CoV-2 infected patients develop neurological symptoms which could last for months after regress of respiratory syndrome. The most common neurological disturbances associated with COVID-19 are fatigue, asthenia, cognitive impairment, smell and taste decrease, cerebral vascular disease, peripheral neuropathy, pain etc. Clinical symptoms of post-covid syndrome significantly affects the quality of life and working capacity of many patients. Nowadays therapeutic strategies of post-covid syndrome treatment are empirical and are based on possible pathogenesis of neurological complications. Prevention of cerebral vascular events and neurometabolic treatment of cognitive and asthenic disorders should play an important role in management of COVID-19 patients. Pentoxifylline could be considered as coadjuvant measure in treatment of post-covid neurological symptoms because of its multimodal effects.

Новой проблемой современной клинической медицины является постковидный синдром (ПКС). Приблизительно у трети инфицированных SARS-CoV-2 развивается неврологическая симптоматика, которая может сохраняться в течение многих месяцев. Чаще всего в постковидном периоде наблюдаются астения, когнитивные нарушения, снижение обоняния и вкуса, инсульты, периферические невропатии и болевые синдромы. ПКС оказывает существенное влияние на качество жизни и работоспособность пациентов. В настоящее время подходы к терапии ПКС являются эмпирическими и основываются на представлениях о патогенезе неврологических осложнений. Важное место занимает профилактика цереброваскулярных событий и нейрометаболическая терапия. Благодаря мультимодальному плейотропному эффекту пентоксифиллина, данный препарат может рассматриваться в качестве патогенетически обоснованной адъювантной терапии у пациентов с неврологическим ПКС.

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