TherapyTherapyТерапия2412-40362713-1823Bionika Media28878010.18565/therapy.2022.1.162-173ArticlesСтатьиResearch ArticleCombined hypolipidemic therapy for mixed atherogenic dyslipidemia: reviewВозможности комбинированной гиполипидемической терапии смешанной атерогенной дислипидемииBoevaOlga I.БоеваОльга Игоревна

MD, PhD, DMSci., professor of the Department of therapy, cardiology and functional diagnostics with the course of nephrology

д.м.н., доцент, профессор кафедры терапии, кардиологии и функциональной диагностики с курсом нефрологии

box0271@mail.ruKokorinValentin A.КокоринВалентин Александрович

MD, PhD, DMSci., professor of the department of hospital therapy named after academician P.E. Lukomsky

д.м.н., доцент, профессор кафедры госпитальной терапии имени академика П.Е. Лукомского лечебного факультета

valentinkokorin@yahoo.comKhripunovaAlesya A.ХрипуноваАлеся Александровна

MD, PhD, associate professor of the Department of public health and health care, medical prevention and informatics

к.м.н., доцент, доцент кафедры общественного здоровья и здравоохранения, медицинской профилактики и информатики с курсом ДПО

fktcz2007@yandex.ru''Central State Medical Academy of the Presidential Executive OfficeФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента РФN.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of RussiaФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииStavropol State Medical University of the Ministry of Healthcare of RussiaФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава России1501202281VOL 8, NO1 (2022)ТОМ 8, №1 (2022)16217326022023Copyright ©; 2022, “Bionika Media” LLCCopyright ©; 2022, ООО «Бионика Медиа»2022“Bionika Media” LLCООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/about/editorialPolicieshttps://journals.eco-vector.com/2412-4036/article/view/288780

High plasma levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) in combination with reduced high-density lipoprotein cholesterol (HDL-C) level is a common dyslipidemia. Statin therapy effectively reduces LDL-C, but is not always sufficient to optimize the overall lipid profile, exposing the patient to residual cardiovascular risk. The analysis of current literature on the efficacy and safety of statins and fibric acid derivatives combination for the correction of mixed dyslipidemia and prevention of cardiovascular risk.

Сочетание повышения холестерина липопротеидов низкой плотности (ХС ЛНП) и триглицеридов (ТГ) в плазме крови с пониженным уровнем холестерина липопротеидов высокой плотности (ХС ЛВП) - нередкий вариант дислипидемии. Терапия статинами эффективно снижает уровень ХС ЛНП, но не всегда достаточна для оптимизации общего липидного профиля, что создает основу для формирования остаточного сердечно-сосудистого риска. Проведен анализ данных доступной литературы о степени эффективности и безопасности комбинации статинов и производных фиброевой кислоты в коррекции смешанной дислипидемии и профилактике сердечно-сосудистого риска.

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