TherapyTherapyТерапия2412-40362713-1823Bionika Media28879710.18565/therapy.2022.2.24-31ArticlesСтатьиReview ArticleRHEUMATOLOGICAL PROBLEMS WITH COVID-19: FROM ARTHRALGIA TO RHEUMATOID ARTHRITISСУСТАВНОЙ СИНДРОМ ПРИ COVID-19: ОТ АРТРАЛГИЙ ДО РЕВМАТОИДНОГО АРТРИТАKARATEEVAndrey E.КАРАТЕЕВАндрей Евгеньевич

MD, head of the Department of inflammatory joint pathology

д.м.н., начальник отдела воспалительных заболеваний суставов

aekarat@yandex.ruV.A. Nasonova Research Institute of RheumatologyФГБУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»1502202282VOL 8, NO2 (2022)ТОМ 8, №2 (2022)243126022023Copyright ©; 2022, Bionika MediaCopyright ©; 2022, ООО «Бионика Медиа»2022Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/article/view/288797

SARS-CoV-2 infection (COVID-19) can cause a systemic inflammatory response, vascular and thrombotic complications, and a wide range of autoimmune disorders. These changes can lead to the development of various rheumatological pathologies. At the onset of the disease, according to series of studies, myalgia is observed in 50,0-84,0%, arthralgia in 13,3-90,0% of patients. After suffering COVID-19, patients could have the situation when joint pain becomes one of the leading manifestations of post-COVID syndrome: on average, it is determined in 15% of cases. Autoimmune reactions associated with SARS-CoV-2 can cause acute post-infectious arthritis, which is characterized mainly by oligoarticular lesions of the joints of the lower extremities, a benign course, and a good «response» to anti-inflammatory therapy. In some cases, COVID-19 acts as a trigger, initiating the development of chronic autoimmune rheumatic diseases, such as systemic vasculitis, systemic lupus erythematosus and rheumatoid arthritis.

Инфекция, вызванная вирусом SARS-CoV-2 (COVID-19), может вызывать системную воспалительную реакцию, сосудистые и тромботические осложнения, широкий спектр аутоиммунных нарушений. Эти изменения могут приводить к развитию различной ревматологической патологии. В дебюте болезни, по данным серии исследований, миалгии отмечаются у 50,0-84,0%, артралгии - у 13,3-90,0% пациентов. После перенесенного COVID-19 боли в суставах становятся одним из ведущих проявлений постковидного синдрома: в среднем они определяются в 15% случаев. Аутоиммунные реакции, связанные с SARS-CoV-2, могут вызывать возникновение острого постинфекционного артрита, который характеризуется преимущественно олигоартрикулярным поражением суставов нижней конечностей, доброкачественным течением, хорошим «ответом» на противовоспалительную терапию. В ряде случаев COVID-19 выступает в роли пускового фактора, инициируя развитие хронических аутоиммунных ревматических заболеваний, таких как системные васкулиты, системная красная волчанка и ревматоидный артрит.

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