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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">288810</article-id><article-id pub-id-type="doi">10.18565/therapy.2022.2.57-64</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">CLINICAL MANIFESTATIONS OF PANNICULITIS: DIFFICULTIES OF DIAGNOSTICS</article-title><trans-title-group xml:lang="ru"><trans-title>КЛИНИЧЕСКИЕ ПРОЯВЛЕНИЯ ПАННИКУЛИТОВ: ДИАГНОСТИЧЕСКИЕ ТРУДНОСТИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>EGOROVA</surname><given-names>Olga N.</given-names></name><name xml:lang="ru"><surname>ЕГОРОВА</surname><given-names>Ольга Николаевна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, leading researcher of the Laboratory of thromboinflammation</p></bio><bio xml:lang="ru"><p>д.м.н., ведущий научный сотрудник лаборатории тромбовоспаления</p></bio><email>onegorova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>TARASOVA</surname><given-names>Galina M.</given-names></name><name xml:lang="ru"><surname>ТАРАСОВА</surname><given-names>Галина Михайловна</given-names></name></name-alternatives><bio xml:lang="en"><p>senior researcher of the Laboratory of thromboinflammation</p></bio><bio xml:lang="ru"><p>к.м.н., старший научный сотрудник лаборатории тромбовоспаления</p></bio><email>verizubgm@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>LILA</surname><given-names>Alexander M.</given-names></name><name xml:lang="ru"><surname>ЛИЛА</surname><given-names>Александр Михайлович</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, professor, Director</p></bio><bio xml:lang="ru"><p>д.м.н., профессор, директор</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">V.A. Nasonova Research Institute of Rheumatology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2022</year></pub-date><volume>8</volume><issue>2</issue><issue-title xml:lang="en">VOL 8, NO2 (2022)</issue-title><issue-title xml:lang="ru">ТОМ 8, №2 (2022)</issue-title><fpage>57</fpage><lpage>64</lpage><history><date date-type="received" iso-8601-date="2023-02-26"><day>26</day><month>02</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ООО «Бионика Медиа»</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/288810">https://journals.eco-vector.com/2412-4036/article/view/288810</self-uri><abstract xml:lang="en"><p>Article discusses the clinical and diagnostic difficulties of verification of variants of panniculitis. Successful diagnostics of the disease depends on a carefully collected anamnesis containing information about previous diseases, taken medicaments, underlying pathology, as well as an adequate assessment of clinical symptoms, laboratory parameters and identification of typical morphological changes. Three clinical observations of panniculites with main characteristic features of the course of the disease are presented.</p></abstract><trans-abstract xml:lang="ru"><p>В статье обсуждаются клинические и диагностические трудности верификации вариантов панникулитов (Пн). Успех в диагностике заболевания зависит от тщательно собранного анамнеза с указанием сведений о предшествующих заболеваниях, принимаемых лекарственных препаратах, фоновой патологии, а также адекватной оценки клинической симптоматики, лабораторных показателей и выявления типичных морфологических изменений. Представлены три клинические наблюдения Пн с основными признаками течения заболевания.</p></trans-abstract><kwd-group xml:lang="en"><kwd>panniculitis</kwd><kwd>erythema nodosum</kwd><kwd>Lofgren's syndrome</kwd><kwd>lipodermatosclerosis</kwd><kwd>diagnostics of panniculitis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>панникулиты</kwd><kwd>узловатая эритема</kwd><kwd>синдром Лефгрена</kwd><kwd>липодерматосклероз</kwd><kwd>диагностика</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Owen E.D., Logan R., May K., Kalavala M. Panniculitis with an unusual diagnosis. Clin Exp Dermatol. 2020; 45(2): 215-17. https://dx.doi.org/10.1111/ced.13912.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Morita T.C.A.B., Tres G.F.S, Garcia M.S.C. et al. Panniculitides of particular interest to the rheumatologist. 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