TherapyTherapyТерапия2412-40362713-1823Bionika Media28881710.18565/therapy.2022.2.86-95ArticlesСтатьиResearch Article«INCOMPLETE» SYSTEMIC LUPUS ERYTHEMATOSUS IN REAL CLINICAL PRACTICE: DIFFICULTIES OF DIAGNOSIS«НЕПОЛНАЯ» СИСТЕМНАЯ КРАСНАЯ ВОЛЧАНКА В РЕАЛЬНОЙ КЛИНИЧЕСКОЙ ПРАКТИКЕ: ТРУДНОСТИ ДИАГНОСТИКИLILAVictoria A.ЛИЛАВиктория Александровна

postgraduate student of the Department of therapy, rheumatology, examination of temporary disability 95 and quality of medical care named after E.E. Eichwald

аспирант кафедры терапии, ревматологии, экспертизы временной нетрудоспособности и качества медицинской помощи им. Э.Э. Эйхвальда

liu_lo@mail.ruMAZUROVVadim I.МАЗУРОВВадим Иванович

MD, professor, academician of the RAS, head of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald

д.м.н., профессор, академик РАН, зав. кафедрой терапии, ревматологии, экспертизы временной нетрудоспособности и качества медицинской помощи им. Э.Э. Эйхвальда

maz.nwgmu@yandex.ruLILAAlexander M.ЛИЛААлександр Михайлович

MD, professor, Director of V.A. Nasonova Research Institute of Rheumatology, head of the Department of rheumatology, Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

д.м.н., профессор, директор ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой», зав. кафедрой ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

amlila@mail.ruI.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of RussiaФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава РоссииV.A. Nasonova Research Institute of RheumatologyФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of RussiaФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России1502202282VOL 8, NO2 (2022)ТОМ 8, №2 (2022)869526022023Copyright ©; 2022, Bionika MediaCopyright ©; 2022, ООО «Бионика Медиа»2022Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/article/view/288817

Difficulties in diagnosing of systemic lupus erythematosus (SLE) are due to the fact that often the appearance of advanced clinical signs of the disease is preceded by an asymptomatic period with minimal laboratory manifestations of the disease. If less than 4 2012 SLICC criteria are met, the term «incomplete» SLE is currently used in clinical practice. The presented lecture considers in details autoimmune phenomena in the asymptomatic period of the disease (so-called preclinical SLE), characterizes «incomplete» SLE, its clinical and immunological features, problems of early diagnosis, predictors of the transformation of «incomplete» SLE into «accurate» SLE, presents algorithm for diagnosing and managing that certain category of patients, as well as modern tactics of curation.

Трудности диагностики системной красной волчанки (СКВ) связаны с тем, что нередко появлению развернутых клинических признаков заболевания предшествует бессимптомный период с минимальными лабораторными проявлениями заболевания. При наличии менее 4 критериев SLICC 2012 г. в клинической практике в настоящее время используется термин «неполная» СКВ. В представленной лекции подробно рассматриваются аутоиммунные феномены в бессимптомный период заболевания (так называемая доклиническая СКВ), дана характеристика «неполной» СКВ, освещены ее клинико-иммунологические особенности, проблемы ранней диагностики, предикторы трансформации «неполной» СКВ в «достоверную», представлены алгоритм диагностики и ведения данной категории пациентов, а также современная тактика лечения.

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