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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">624537</article-id><article-id pub-id-type="doi">10.18565/therapy.2023.6.50–58</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Based on materials of community-acquired pneumonia – an European Federation of internal medicine guideline critical appraisal adaptation for internists: important answers to difficult questions</article-title><trans-title-group xml:lang="ru"><trans-title>По материалам обзора клинических рекомендаций Европейской Федерации внутренней медицины по внебольничной пневмонии: важные ответы на сложные вопросы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8614-6542</contrib-id><name-alternatives><name xml:lang="en"><surname>Kokorin</surname><given-names>Valentin A.</given-names></name><name xml:lang="ru"><surname>Кокорин</surname><given-names>Валентин Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>md, associate professor, professor of the department of hospital therapy </p></bio><bio xml:lang="ru"><p>д.м.н., доцент, профессор кафедры госпитальной терапии </p></bio><email>valentinkokorin@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7825-5597</contrib-id><name-alternatives><name xml:lang="en"><surname>Larina</surname><given-names>Vera N.</given-names></name><name xml:lang="ru"><surname>Ларина</surname><given-names>Вера Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>md, professor, head of the department of policlinic therapy</p></bio><bio xml:lang="ru"><p>д.м.н., доцент, профессор кафедры госпитальной терапии </p></bio><email>valentinkokorin@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9002-7749</contrib-id><name-alternatives><name xml:lang="en"><surname>Lunev</surname><given-names>Dmitri I.</given-names></name><name xml:lang="ru"><surname>Лунев</surname><given-names>Виктор Иванович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>assistant at the department of policlinic therapy</p></bio><bio xml:lang="ru"><p>ассистент кафедры поликлинической терапии лечебного факультета</p></bio><email>sandvit@ya.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5959-6759</contrib-id><name-alternatives><name xml:lang="en"><surname>Suvorova</surname><given-names>Natalia A.</given-names></name><name xml:lang="ru"><surname>Суворова</surname><given-names>Наталья Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>assistant at the department of hospital therapy </p></bio><bio xml:lang="ru"><p>ассистент кафедры госпитальной терапии </p></bio><email>natalia-suvorova@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2023</year></pub-date><volume>9</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>50</fpage><lpage>58</lpage><history><date date-type="received" iso-8601-date="2023-12-13"><day>13</day><month>12</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-12-13"><day>13</day><month>12</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО «Бионика Медиа»</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/624537">https://journals.eco-vector.com/2412-4036/article/view/624537</self-uri><abstract xml:lang="en"><p>A brief review of the clinical guidelines of the European Federation of Internal Medicine on community-acquired pneumonia (CAP), prepared in the form of answers to unsolved clinical questions in the PICO format (P – patient /I – intervention/ C – comparison/ O – outcomes), regarding the peculiarities of managing patients with multimorbidity is presented. The necessity of identification of respiratory viruses in the initial diagnosis of CAP during respiratory virus season, the use of clinical prediction rule for prognosis as an additional method for decision-making concerning the need and place of hospitalization, and the assessment of drug interactions in multimorbid patients with CAP while choosing antimicrobial therapy (AMT) are discussed. Attention is paid to the factors that should be considered before starting AMT in both outpatient and inpatient settings and biomarkers of infection to manage AMT.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен краткий обзор клинических рекомендаций Европейской федерации внутренней медицины по внебольничной пневмонии (ВП), подготовленный в виде ответов на актуальные вопросы в формате PICO (П – пациент/P – patient; В – вмешательство/ I – intervention; С – сравнение/C – comparison; И – исходы/O – outcomes), касательно особенностей ведения пациентов в разных клинических ситуациях. Обсуждается необходимость идентификации респираторных вирусов при первичной диагностике ВП во время сезонных вспышек заболеваемости, применения прогностических шкал в качестве дополнительного метода для принятия решения о необходимости и месте госпитализации, оценки межлекарственных взаимодействий у мультиморбидных пациентов с ВП при выборе антибактериальной терапии (АБТ). Уделяется внимание факторам, которые следует учитывать перед началом АБТ как в амбулаторных, так и госпитальных условиях, а также биомаркерам инфекции для контроля за назначением АБТ.</p></trans-abstract><kwd-group xml:lang="en"><kwd>community-acquired pneumonia</kwd><kwd>clinical guidelines</kwd><kwd>European Federation of Internal Medicine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>внебольничная пневмония</kwd><kwd>клинические рекомендации</kwd><kwd>Европейская федерация внутренней медицины</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Министерство здравоохранения Российской Федерации. Заболеваемость взрослого населения России в 2019 г. Часть III. М. 2020; 160 с. [Ministry of Healthcare of Russia. The incidence of the adult population of Russia in 2019. Part III. 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