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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">625444</article-id><article-id pub-id-type="doi">10.18565/therapy.2023.7.208–213</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ACTUAL ISSUES OF PHARMACOTHERAPY AND PREVENTIVE TREATMENT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ ФАРМАКОТЕРАПИИ И ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Impact of long-term antiarrhythmic therapy on the progression of atrial fibrillation from paroxysmal to permanent form</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние длительной антиаритмической терапии на прогрессирование фибрилляции предсердий от пароксизмальной к постоянной форме</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9536-8307</contrib-id><name-alternatives><name xml:lang="en"><surname>Tarzimanova</surname><given-names>Aida I.</given-names></name><name xml:lang="ru"><surname>Тарзиманова</surname><given-names>Аида Ильгизовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, professor of the Department of faculty therapy No. 2</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор кафедры факультетской терапии № 2</p></bio><email>tarzimanova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2023</year></pub-date><volume>9</volume><issue>7</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>208</fpage><lpage>213</lpage><history><date date-type="received" iso-8601-date="2024-01-02"><day>02</day><month>01</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-01-02"><day>02</day><month>01</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО «Бионика Медиа»</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/625444">https://journals.eco-vector.com/2412-4036/article/view/625444</self-uri><abstract xml:lang="en"><p>In recent years, it has been proven that there is a certain pattern in the long-term course of atrial fibrillation (AF): from asymptomatic, short episodes of arrhythmia to a stable permanent form of the disease, which creates the prerequisites for the progression of chronic heart failure and significantly worsens the prognosis for patients. The duration of the existence of paroxysmal or persistent form of AF in different patients can vary in a wide range – from several months to decades – and is interconnected with the severity of underlying disease. Paroxysmal AF persists for many years in only a small part of patients. Slowing the progression of AF from paroxysmal to permanent form improves the prognosis of patients, therefore, the assessment of risk factors for the progression of arrhythmia and prescription the correct tactics for managing patients are urgent tasks of modern cardiology.</p></abstract><trans-abstract xml:lang="ru"><p>В последние годы было доказано, что существует определенная закономерность при многолетнем течении фибрилляции предсердий (ФП): от бессимптомных, коротких эпизодов аритмии, до устойчивой постоянной формы заболевания, которая создает предпосылки к прогрессированию хронической сердечной недостаточности и значительно ухудшает прогноз пациентов. Продолжительность существования пароксизмальной или персистирующей формы ФП у разных пациентов может варьировать в большом диапазоне – от нескольких месяцев до десятилетий – и взаимосвязана с тяжестью основного заболевания. Пароксизмальная ФП сохраняется в течение многих лет только у небольшой части пациентов. Замедление прогрессирования ФП от пароксизмальной к постоянной форме позволяет улучшить прогноз пациентов, поэтому оценка факторов риска прогрессирования аритмии и назначение правильной тактики ведения пациентов являются актуальными задачами современной кардиологии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>progression of atrial fibrillation</kwd><kwd>antiarrhythmic therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>прогрессирование фибрилляции предсердий</kwd><kwd>антиаритмическая терапия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Hindricks G., Potpara T., Dagres N. et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. 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