TherapyTherapyТерапия2412-40362713-1823Bionika Media62616810.18565/therapy.2023.9.135-142REVIEWSОБЗОРЫReview ArticleDiagnostic and therapeutic aspects of irisin in cardiovascular pathology and metabolic disordersДиагностические и лечебные аспекты иризина при кардиоваскулярной патологии и нарушениях метаболизмаhttps://orcid.org/0000-0001-5416-8579AlievaAmina M.АлиеваАмина Магомедовна
Russian Federation

PhD in Medical Sciences, Associate Professor of the Department of Hospital Therapy named after Academician G.I. Storozhakov of the Faculty of General Medicine

к.м.н., доцент кафедры госпитальной терапии имени академика Г.И. Сторожакова лечебного факультета

amisha_alieva@mail.ruhttps://orcid.org/0000-0003-1699-0881NikitinIgor G.НикитинИгорь Геннадиевич
Russian Federation

MD, Professor, Head of the Department of Hospital Therapy named after Academician G.I. Storozhakov of the Faculty of General Medicine

д.м.н., профессор, заведующий кафедрой госпитальной терапии имения академика Г.И. Сторожакова лечебного факультета

amisha_alieva@mail.ruhttps://orcid.org/0000-0002-7181-4680TeplovaNatalya V.ТепловаНаталья Вадимовна
Russian Federation

MD, Professor, Head of the Department of Clinical Pharmacology of the Faculty of General Medicine

д.м.н., профессор, заведующий кафедрой клинической фармакологии лечебного факультета

amisha_alieva@mail.ruhttps://orcid.org/0000-0003-0886-6290BaykovaIrina E.БайковаИрина Евгеньевна
Russian Federation

PhD in Medical Sciences, Associate Professor of the Department of Hospital Therapy named after Academician G.I. Storozhakov of the Faculty of General Medicine

к.м.н., доцент кафедры госпитальной терапии имени академика Г.И. Сторожакова лечебного факультета

amisha_alieva@mail.ruhttps://orcid.org/0000-0001-9601-1174RakhaevAlik M.РахаевАлик Магомедович
Russian Federation

MD, Head of the Expert Staff

д.м.н., руководитель экспертного состава

amisha_alieva@mail.ruhttps://orcid.org/0009-0003-9017-7191KudaevaMadina V.КудаеваМадина Владимировна
Russian Federation

Doctor for Medical and Social Expertise, Therapist at the Expert Staff

врач по медико-социальной экспертизе, терапевт экспертного состава

amisha_alieva@mail.ruhttps://orcid.org/0009-0003-8949-0017SozaevaMalika R.СозаеваМалика Рамазановна
Russian Federation

Student of the Faculty of Pediatrics

студентка педиатрического факультета

amisha_alieva@mail.ruhttps://orcid.org/0000-0001-5352-8499KotikovaIrina A.КотиковаИрина Александровна
Russian Federation

Student of the Faculty of General Medicine

студентка лечебного факультета

amisha_alieva@mail.ruN.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of RussiaФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииMain Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic of the Ministry of Labor and Social Protection of RussiaФКУ «Главное бюро медико-социальной экспертизы по Кабардино-Балкарской Республике» Министерства труда и социальной защиты РоссииKh.M. Berbekov Kabardino-Balkarian State UniversityФГБОУ ВО «Кабардино-Балкарский государственный университет им. Х.М. Бербекова»15092023991351422801202428012024Copyright ©; 2023, Bionika MediaCopyright ©; 2023, ООО «Бионика Медиа»2023Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/article/view/626168

Despite significant advances in medicine, cardiovascular disease continues to be the leading cause of death worldwide. An important task of modern cardiology is the search and study of new cardiovascular biological markers. The purpose of the presented review is to analyze studies devoted to the study of irisin as a diagnostic and prognostic marker in cardiometabolic diseases. According to the results obtained, an important diagnostic and prognostic significance of the irisin assessment was revealed. Further studies will show the possibility of using this biomarker as an additional diagnostic and prognosis tool. Regulation of irisin concentration and expression may prove to be a promising strategy for the treatment of cardiac patients.

Несмотря на значительные достижения медицины, сердечно-сосудистые заболевания продолжают оставаться ведущей причиной смертности во всем мире. Важной задачей современной кардиологии является поиск и изучение новых сердечно-сосудистых биологических маркеров. Цель представленного обзора – анализ исследований, посвященных изучению иризина в качестве диагностического и прогностического маркера при кардиометаболических заболеваниях. Согласно полученным результатам, выявлена важная диагностическая и прогностическая значимость оценки иризина. Дальнейшие исследования покажут возможность использования этого биомаркера как дополнительного инструмента диагностики кардиоваскулярных патологий и оценки прогноза. Регуляция концентрации и экспрессии иризина, возможно, окажется многообещающей стратегией для лечения больных кардиологического профиля.

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