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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">626169</article-id><article-id pub-id-type="doi">10.18565/therapy.2023.9.144-149</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Infectious endocarditis in a patient with a transplanted kidney on a conventional hemodialysis</article-title><trans-title-group xml:lang="ru"><trans-title>Инфекционный эндокардит у пациента с трансплантированной почкой на программном гемодиализе</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-4321-1927</contrib-id><name-alternatives><name xml:lang="en"><surname>Kozlova</surname><given-names>Anna A.</given-names></name><name xml:lang="ru"><surname>Козлова</surname><given-names>Анна Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant at the Department of Hospital Therapy named after P.E. Lukomsky of the Faculty of General Medicine</p></bio><bio xml:lang="ru"><p>ассистент кафедры госпитальной терапии им. академика П.Е. Лукомского лечебного факультета </p></bio><email>annakoz15@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-4877-9569</contrib-id><name-alternatives><name xml:lang="en"><surname>Agafonova</surname><given-names>Yulia S.</given-names></name><name xml:lang="ru"><surname>Агафонова</surname><given-names>Юлия Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6th year student of the Faculty of General Medicine</p></bio><bio xml:lang="ru"><p>студентка 6-го курса лечебного факультета </p></bio><email>yuliaagaf2000@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-2468-2200</contrib-id><name-alternatives><name xml:lang="en"><surname>Timofeev</surname><given-names>Roman G.</given-names></name><name xml:lang="ru"><surname>Тимофеев</surname><given-names>Роман Геннадьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6th year student of the Faculty of General Medicine</p></bio><bio xml:lang="ru"><p>студент 6-го курса лечебного факультета </p></bio><email>Timofrg@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mayorov</surname><given-names>Vasily V.</given-names></name><name xml:lang="ru"><surname>Майоров</surname><given-names>Василий Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Head of the Department of Nephrology</p></bio><bio xml:lang="ru"><p>зав. нефрологическим отделением </p></bio><email>Vasso88-88@bk.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Merkusheva</surname><given-names>Elena P.</given-names></name><name xml:lang="ru"><surname>Меркушева</surname><given-names>Елена Петровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Nephrologist at the Department of Nephrology</p></bio><bio xml:lang="ru"><p>врач-нефролог нефрологического отделения </p></bio><email>lucky666_92@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8614-6542</contrib-id><name-alternatives><name xml:lang="en"><surname>Kokorin</surname><given-names>Valentin A.</given-names></name><name xml:lang="ru"><surname>Кокорин</surname><given-names>Валентин Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Associate Professor, Professor the Department of Hospital Therapy named after P.E. Lukomsky of the Faculty of General Medicine</p></bio><bio xml:lang="ru"><p>д.м.н., доцент, профессор кафедры госпитальной терапии им. академика П.Е. Лукомского лечебного факультета </p></bio><email>valentinkokorin@yahoo.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">O.M. Filatov Municipal Clinical Hospital No. 15 of the Department of Healthcare of Moscow</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Городская клиническая больница № 15 им. О.М. Филатова Департамента здравоохранения Москвы»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2023</year></pub-date><volume>9</volume><issue>9</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>144</fpage><lpage>149</lpage><history><date date-type="received" iso-8601-date="2024-01-28"><day>28</day><month>01</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-01-28"><day>28</day><month>01</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО «Бионика Медиа»</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/626169">https://journals.eco-vector.com/2412-4036/article/view/626169</self-uri><abstract xml:lang="en"><p>Infectious endocarditis remains challenging to diagnose, especially for patients with no apparent clinical symptoms. The presented clinical case describes a rapid progression of sepsis and challenges in treating a patient with risk factors, including undergoing immunosuppressive therapy due to a transplanted kidney, renal failure and the need for conventional dialysis. The case report highlights the significance of frequent monitoring of patients with the described risk factors, and emphasises the critical role of adopting more aggressive treatment strategies during the initial phases of the disease.</p></abstract><trans-abstract xml:lang="ru"><p>Инфекционный эндокардит остается трудным с точки зрения диагностики заболеванием, особенно у пациентов со стертым течением болезни. В данном клиническом случае описаны достаточно стремительное распространение септического процесса и сложности лечения у пациента, имеющего в качестве факторов риска прием иммуносупрессивной терапии по поводу трансплантированной почки, прогрессирование почечной недостаточности, необходимость программного гемодиализа. Приведенный пример демонстрирует важность тщательного контроля над состоянием больных данного профиля и принятия более радикальной тактики лечения на ранних стадиях заболевания.</p></trans-abstract><kwd-group xml:lang="en"><kwd>infectious endocarditis</kwd><kwd>conventional hemodialysis</kwd><kwd>transplanted kidney</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>инфекционный эндокардит</kwd><kwd>программный гемодиализ</kwd><kwd>трансплантированная почка</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>McCreery R.J., Florescu D.F., Kalil A.C. Sepsis in immunocompromised patients without human immunodeficiency virus. J Infect Dis. 2020; 222(Suppl 2): S156–65. https://dx.doi.org/10.1093/infdis/jiaa320.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Демин А.А., Кобалава Ж.Д., Скопин И.И. с соавт. Инфекционный эндокардит и инфекция внутрисердечных устройств у взрослых. 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