<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">626177</article-id><article-id pub-id-type="doi">10.18565/therapy.2023.9.168-175</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ACTUAL ISSUES OF PHARMACOTHERAPY AND PREVENTIVE TREATMENT</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ ФАРМАКОТЕРАПИИ И ПРОФИЛАКТИКИ ЗАБОЛЕВАНИЙ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Vegetative dysfunction syndrome: Diagnosis and treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Синдром вегетативной дисфункции: диагностика и лечение</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3908-0381</contrib-id><name-alternatives><name xml:lang="en"><surname>Kotova</surname><given-names>Olga V.</given-names></name><name xml:lang="ru"><surname>Котова</surname><given-names>Ольга Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD in Medical Sciences, Neurologist, Psychiatrist, Psychotherapist, Associate Professor of the Department of Psychiatry, Psychotherapy and Psychosomatic Pathology of the Faculty of Continuing Medical Education, Peoples’ Friendship University of Russia; Vice President of the International Society «Stress under Control»</p></bio><bio xml:lang="ru"><p>к.м.н., врач-невролог, психиатр, психотерапевт, доцент кафедры психиатрии, психотерапии и психосоматической патологии ФНМО Медицинского института ФГАОУ ВО «Российский университет дружбы народов»; вице-президент Международного общества «Стресс под контролем»</p></bio><email>ol_kotova@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7186-870X</contrib-id><name-alternatives><name xml:lang="en"><surname>Belyaev</surname><given-names>Anton A.</given-names></name><name xml:lang="ru"><surname>Беляев</surname><given-names>Антон Андреевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Neurologist, Junior Researcher at the Department of Emergency Vascular Surgery</p></bio><bio xml:lang="ru"><p>невролог, младший научный сотрудник отделения неотложной сосудистой хирургии </p></bio><email>ol_kotova@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7629-3773</contrib-id><name-alternatives><name xml:lang="en"><surname>Akarachkova</surname><given-names>Elena S.</given-names></name><name xml:lang="ru"><surname>Акарачкова</surname><given-names>Елена Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Neurologist, President of the International Society «Stress under Control», Deputy Chief Physician of the Rehaline Rehabilitation Center</p></bio><bio xml:lang="ru"><p>д.м.н., врач-невролог, президент Международного общества «Стресс под контролем», зам. главного врача реабилитационного центра Rehaline</p></bio><email>ol_kotova@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7526-1553</contrib-id><name-alternatives><name xml:lang="en"><surname>Borodulina</surname><given-names>Irina V.</given-names></name><name xml:lang="ru"><surname>Бородулина</surname><given-names>Ирина Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD in Medical Sciences, Neurologist</p></bio><bio xml:lang="ru"><p>к.м.н., невролог</p></bio><email>ol_kotova@mail.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pavlova</surname><given-names>Svetlana V.</given-names></name><name xml:lang="ru"><surname>Павлова</surname><given-names>Светлана Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD in Medical Sciences, Chief Physician </p></bio><bio xml:lang="ru"><p>к.м.н., главный врач </p></bio><email>ol_kotova@mail.ru</email><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Медицинский институт ФГАОУ ВО «Российский университет дружбы народов»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">International Society «Stress under Control»</institution></aff><aff><institution xml:lang="ru">Международное общество «Стресс под контролем»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">N.V. Sklifosovsky Research Institute of Emergency Medicine of the Department of Healthcare of Moscow</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения города Москвы»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Children’s City Clinic No. 39 of the Department of Healthcare of Moscow</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Детская городская поликлиника № 39 Департамента здравоохранения города Москвы»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2023</year></pub-date><volume>9</volume><issue>9</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>168</fpage><lpage>175</lpage><history><date date-type="received" iso-8601-date="2024-01-28"><day>28</day><month>01</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-01-28"><day>28</day><month>01</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ООО «Бионика Медиа»</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/626177">https://journals.eco-vector.com/2412-4036/article/view/626177</self-uri><abstract xml:lang="en"><p>As an official diagnosis for autonomic disorders, ICD-10 uses code G90 – «disorders of the autonomic nervous system». According to a survey of 206 neurologists and therapists in Russia, 97% of respondents use the diagnosis «vegetative dysfunction syndrome» (VDS) in their practice. Among its symptoms are asthenia, functional dizziness, breathing disorders, paroxysmal conditions, etc. VDS always develops against the background of anxiety and/or depressive disorders, and therefore the entire range of psychotropic drugs is used in outpatient practice – antidepressants, tranquilizers, antipsychotics. However, the patients are not always ready to accept psychotropic therapy, so there is often a need to search for alternative treatment strategies for VDS, including the use of herbal drugs and nootropics. Complex therapy with Picamilon and Corvalol Phyto/Phytocomfort makes it possible to level out, and in some cases stabilize, the manifestations of autonomic dysfunction by its impact on the pathogenesis of VDS.</p></abstract><trans-abstract xml:lang="ru"><p>В качестве официального диагноза для обозначения вегетативных расстройств в МКБ-10 используется код G90 – «расстройства вегетативной (автономной) нервной системы». По данным опроса 206 неврологов и терапевтов России, 97% опрошенных применяют в своей практике диагноз «синдром вегетативной дисфункции» (СВД). Среди его симптомов встречаются астения, функциональное головокружение, нарушения дыхания, пароксизмальные состояния и др. СВД всегда развивается на фоне тревожных и/или депрессивных расстройств, в связи с чем в амбулаторной практике применяется весь спектр психотропных препаратов – антидепрессанты, транквилизаторы, нейролептики. Однако пациент не всегда готов принимать психотропную терапию, поэтому часто возникает необходимость поиска альтернативных стратегий лечения СВД, в том числе с применением растительных препаратов и ноотропов. Комплексная терапия препаратами Пикамилон и Корвалол Фито/Фитокомфорт позволяет нивелировать, а в некоторых случаях стабилизировать проявления вегетативной дисфункции через воздействие на патогенез СВД.</p></trans-abstract><kwd-group xml:lang="en"><kwd>vegetative dysfunction syndrome</kwd><kwd>medically unexplained symptoms</kwd><kwd>herbal remedies</kwd><kwd>nootropic drugs</kwd><kwd>Picamilon</kwd><kwd>Corvalol Phyto</kwd><kwd>Corvalol Phytocomfort</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>синдром вегетативной дисфункции</kwd><kwd>необъяснимые с медицинской точки зрения симптомы</kwd><kwd>фитопрепараты</kwd><kwd>ноотропные препараты</kwd><kwd>Пикамилон</kwd><kwd>Корвалол Фито</kwd><kwd>Корвалол Фитокомфорт</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Котова О.В., Акарачкова Е.С., Беляев А.А. Психовегетативный синдром: трудности диагностики и эффективного лечения. Медицинский совет. 2018; (21): 50–55. [Kotova О.V., Akarachkova E.S., Belyaev A.A. Psychovegetative syndrome: Challenges in diagnosis and effective treatment. Meditsinskiy sovet = Medical Council. 2018; (21): 50–55 (In Russ.)]. https://dx.doi.org/10.21518/2079-701X-2018-21-50-55. EDN: YTUVDN.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Орлова И., Орлов Ф., Голенков А. Психовегетативные синдромы у неврологических больных. Врач. 2019; 30(12): 18–21. [Orlova I., Orlov F., Golenkov A. Psychoautonomic syndromes in neurological patients. Vrach = The Doctor. 2019; 30(12): 18–21 (In Russ.)]. https://dx.doi.org/10.29296/25877305-2019-12-05. EDN: BNYUNI.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Акарачкова Е.С. К вопросу диагностики и лечения психовегетативных расстройств в общесоматической практике. Лечащий врач. 2010; (10): 60. [Akarachkova E.S. Revisiting the diagnosis and treatment of psycho-vegetative disorders in general practice. Lechaschiy vrach = Attending Physician. 2010; (10): 60 (In Russ.)]. EDN: SGGGTJ.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Rief W., Martin A. How to use the new dsm-5 somatic symptom disorder diagnosis in research and practice: A critical evaluation and a proposal for modifications. Annu Rev Clin Psychol. 2014; 10: 339–67. https://dx.doi.org/10.1146/annurev-clinpsy-032813-153745.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Rice A.S., Smith B.H., Blyth F.M. Pain and the global burden of disease. Pain. 2016; 157(4): 791–96. https://dx.doi.org/10.1097/j.pain.0000000000000454.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Психиатрические аспекты неврологических заболеваний. Подходы к ведению больных. Под ред. К.Г. Ликетсоса, П.В. Рэбинса, Дж.Р. Липси, Ф.Р. Слэвни. М.: МЕДпресс-информ. 2017; 328 c. [Psychiatric aspects of neurological diseases. Approaches to the management of patients. Ed. by Lyketsos K.G., Rabins P.V., Lipsi J.R., Slevi F.R. Moscow: MEDpress-inform. 2017; 328 pp. (In Russ.)]. ISBN: 978-5-00030-393-1.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Вегетативные расстройства: клиника, лечение, диагностика. Руководство для врачей. Под ред. А.М. Вейна, Голубева В.Л. М.: Медицинское информационное агентство. 2010; 637 с. [Vegetative disorders: Clinic, treatment, diagnosis. A guide for physicians. Ed. by Wayne A.M., Golubev V.L. Moscow: Medical News Agency. 2010; 637 pp. (In Russ.)]. ISBN: 978-5-89481-808-5. EDN: QLWDYN.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Котова О.В. Возможности терапии психовегетативного синдрома. Трудный пациент. 2011; 9(12): 24–27. [Kotova O.V. Options for treatment of psycho-vegetative syndrome. Trudny patsient = Difficult Patient. 2011; 9(12): 24–27 (In Russ.)]. EDN: PBIGPJ.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Kroenke K. Patients presenting with somatic complaints: Epidemiology, psychiatric comorbidity and management. Int J Methods Psychiatr Res. 2003; 12(1): 34–43. https://dx.doi.org/10.1002/mpr.140.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Aiarzaguena J.M., Grandes G., Salazar A. et al. The diagnostic challenges presented by patients with medically unexplained symptoms in general practice. Scand J Prim Health Care. 2008; 26(2): 99–105. https://dx.doi.org/10.1080/02813430802048662.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Liao S.C., Ma H.M., Lin Y.L., Huang W.L. Functioning and quality of life in patients with somatic symptom disorder: The association with comorbid depression. Compr Psychiatry. 2019; 90: 88–94. https://dx.doi.org/10.1016/j.comppsych.2019.02.004.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Chew-Graham C.A., Heyland S., Kingstone T. et al. Medically unexplained symptoms: Continuing challenges for primary care. Br J Gen Pract. 2017; 67(656): 106–7. https://dx.doi.org/10.3399/bjgp17X689473.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Walsemann K.M., Gee G.C., Ro A. Educational attainment in the context of social inequality: New directions for research on education and health. Am Behav Sci. 2013; 57(8): 1082–104. https://dx.doi.org/10.1177/0002764213487346.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Evangelidou S., NeMoyer A., Cruz-Gonzalez M. et al. Racial/ethnic differences in general physical symptoms and medically unexplained physical symptoms: Investigating the role of education. Cultur Divers Ethnic Minor Psychol. 2020; 26(4): 557–69. https://dx.doi.org/10.1037/cdp0000319.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Escobar J.I., Cook B., Chen C.N. et al. Whether medically unexplained or not, three or more concurrent somatic symptoms predict psychopathology and service use in community populations. J Psychosom Res. 2010; 69(1): 1–8. https://dx.doi.org/10.1016/j.jpsychores.2010.01.001.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Kisely S., Simon G. An international study comparing the effect of medically explained and unexplained somatic symptoms on psychosocial outcome. J Psychosom Res. 2006; 60(2): 125–30. https://dx.doi.org/10.1016/j.jpsychores.2005.06.064.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>van Eck van der Sluijs J., Ten Have M., Rijnders C. et al. Medically unexplained and explained physical symptoms in the general population: Association with prevalent and incident mental disorders. PLoS One. 2015; 10(4): e0123274. https://dx.doi.org/10.1371/journal.pone.0123274.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>De Waal M.W.M., Arnold I.A., Eekhof J.A., Van Hemert A.M. Somatoform disorders in general practice: Prevalence, functional impairment and comorbidity with anxiety and depressive disorders. Br J Psychiatry. 2004; 184: 470–76. https://dx.doi.org/10.1192/bjp.184.6.470.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Drayer R.A., Mulsant B.H., Lenze E.J. et al. Somatic symptoms of depression in elderly patients with medical comorbidities. Int J Geriatr Psychiatry. 2005; 20(10): 973–82. https://dx.doi.org/10.1002/gps.1389.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Kirmayer L.J., Young A. Culture and context in the evolutionary concept of mental disorder. J Abnorm Psychol. 1999; 108(3): 446–52. https://dx.doi.org/10.1037//0021-843x.108.3.446.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Whiteford H.A., Degenhardt L., Rehm J. et al.. Global burden of disease attributable to mental and substance use disorders: Findings from the Global Burden of Disease Study 2010. Lancet. 2013; 382(9904): 1575–86. https://dx.doi.org/10.1016/S0140-6736(13)61611-6.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Zuberi A., Waqas A., Naveed S. et al. Prevalence of mental disorders in the WHO Eastern Mediterranean region: A systematic review and meta-analysis. Front Psychiatry. 2021; 12: 665019. https://dx.doi.org/10.3389/fpsyt.2021.665019.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Акарачкова Е.С., Котова О.В., Вершинина С.В., Рябоконь И.В. Стресс и расстройства адаптации. Лечащий врач. 2014; (6): 61. [Akarachkova E.S., Kotova O.V., Vershinina S.V., Ryabokon I.V. Stress and adjustment disorders. Lechaschiy vrach = Attending Physician. 2014; (6): 61 (In Russ.)]. EDN: SFAZTH.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Котова О.В., Медведев В.Э., Акарачкова Е.С., Беляев А.А. Ковид-19 и стресс-связанные расстройства. Журнал неврологии и психиатрии им. С.С. Корсакова. 2021; 121(5–2): 122–128. [Kotova O.V., Medvedev V.E., Akarachkova E.S., Belyaev A.A. COVID-19 and stress-related disorders. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry. 2021; 121(5–2): 122–128 (In Russ.)]. https://dx.doi.org/10.17116/jnevro2021121052122. EDN: FMGHUN.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Акарачкова Е.С., Климов Л.В., Котова О.В. 21 век: от пандемии COVID-19 к новым психосоциальным стрессам. Клиническое руководство. М.: Издательство «Перо». 2022; 34 с. [Akarachkova E.S., Klimov L.V., Kotova O.V. 21st century: From COVID-19 pandemic to new psychosocial stress clinical guidelines. Clinical guide. Moscow: Pero Publishing House. 2022; 34 pp. (In Russ.)]. ISBN: 978-5-00204-108-4. EDN: EEUPXE.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Junghaenel D.U., Christodoulou C., Lai J.-S., Stone A.A. Demographic correlates of fatigue in the US general population: results from the patient-reported outcomes measurement information system (PROMIS) initiative. J Psychosom Res. 2011; 71(3): 117–23. https://dx.doi.org/10.1016/j.jpsychores.2011.04.007.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Kuratsune H. Overview of chronic fatigue syndrome focusing around prevalence and diagnostic criteria. Nihon Rinsho. 2007; 65(6): 983–90.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Benarroch E.E. Postural tachycardia syndrome: a heterogeneous and multifactorial disorder. Mayo Clin Proc. 2012; 87(12): 1214–25. https://dx.doi.org/10.1016/j.mayocp.2012.08.013.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Reynolds G.K., Lewis D.P., Richardson A.M., Lidbury B.A. Comorbidity of postural orthostatic tachycardia syndrome and chronic fatigue syndrome in an Australian cohort. J Intern Med. 2014; 275(4): 409–17. https://dx.doi.org/10.1111/joim.12161.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Matsuo K., Harada K., Fujita Y. et al. Distinctive neuroanatomical substrates for depression in bipolar disorder versus major depressive disorder. Cereb Cortex. 2019; 29(1): 202–14. https://dx.doi.org/10.1093/cercor/bhx319.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Staab J.P., Eckhardt-Henn A., Horii A. et al. Diagnostic criteria for persistent postural-perceptual dizziness (PPPD): consensus document of the committee for the classification of vestibular disorders of the Barany society. J Vestib Res. 2017; 27(4): 191–208. https://dx.doi.org/10.3233/VES-170622.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Hashimoto K., Takeuchi T., Ueno T. et al. Examination of the effectiveness of antidepressants for functional dizziness with depressive mood by randomized controlled trial – A pilot study. Jpn J Psychosom Med. 2021; 61: 364–70.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Yamamoto S., Ouchi Y., Onoe H. et al. Reduction of serotonin transporters of patients with chronic fatigue syndrome. Neuroreport. 2004; 15(17): 2571–74. https://dx.doi.org/10.1097/00001756-200412030-00002.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Воробьева О.В. Тревожные расстройства в неврологической практике. РМЖ. 2007; 15(24): 1820. [Vorobyova O.V. Anxiety disorders in neurological practice. Russkiy meditsinskiy zhurnal = Russian Medical Journal 2007; 15(24): 1820 (In Russ.)].</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Котова О.В., Максимова Л.Н. Пациент с психовегетативным синдромом: помогает врач общей практики. Фарматека. 2012; (19): 36–41. [Kotova O.V., Maksimova L.N. Patient with psycho-vegetative syndrome: general practitioner helping. Farmateka. 2012; (19): 36–41 (In Russ.)]. EDN: PKEVLX.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Shikov A.N., Pozharitskaya O.N., Makarov V.G. et al. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res. 2011; 25(4): 540–43. https://dx.doi.org/10.1002/ptr.3292.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Cases J., Ibarra A., Feuillere N. et al. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab. 2011; 4(3): 211–18. https://dx.doi.org/10.1007/s12349-010-0045-4.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Гультяева В.В., Зинченко М.И., Урюмцев Д.Ю. с соавт. Физическая нагрузка при лечении депрессии. Физиологические механизмы. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019; 119(7): 112–119. [Gultyaeva V.V., Zinchenko M.I., Uryumtsev D.Yu. et al. Exercise for depression treatment. Physiological mechanisms. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova = S.S. Korsakov Journal of Neurology and Psychiatry. 2019; 119(7): 112–119 (In Russ.)]. https://dx.doi.org/10.17116/jnevro2019119071112. EDN: AWEYKI.</mixed-citation></ref></ref-list></back></article>
