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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">646568</article-id><article-id pub-id-type="doi">10.18565/therapy.2024.9.130-139</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Difficulties of antianginal therapy selecting in an elderly polymorbid patient with coronary heart disease</article-title><trans-title-group xml:lang="ru"><trans-title>Трудности подбора антиангинальной терапии у пожилого полиморбидного пациента с ишемической болезнью сердца</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5801-3742</contrib-id><contrib-id contrib-id-type="spin">9212-6010</contrib-id><name-alternatives><name xml:lang="en"><surname>Kochetkov</surname><given-names>Alexey I.</given-names></name><name xml:lang="ru"><surname>Кочетков</surname><given-names>Алексей Иванович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD (Medicine), associate professor, associate professor of the Department of therapy and polymorbid pathology named after academician M.S. Vovsi</p></bio><bio xml:lang="ru"><p>к. м. н., доцент, доцент кафедры терапии и полиморбидной патологии им. академика М.С. Вовси</p></bio><email>ak_info@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1439-7371</contrib-id><contrib-id contrib-id-type="spin">1755-1594</contrib-id><name-alternatives><name xml:lang="en"><surname>Telkova</surname><given-names>Svetlana S.</given-names></name><name xml:lang="ru"><surname>Телкова</surname><given-names>Светлана Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, 1st year postgraduate student, senior laboratory assistant at the Department of therapy and polymorbid pathology named after academician M.S. Vovsi</p></bio><bio xml:lang="ru"><p>аспирант 1-го года, старший лаборант кафедры терапии и полиморбидной патологии им. академика М.С. Вовси </p></bio><email>svetlana.t03@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-6383-0016</contrib-id><name-alternatives><name xml:lang="en"><surname>Dubinina</surname><given-names>Anna V.</given-names></name><name xml:lang="ru"><surname>Дубинина</surname><given-names>Анна Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, 2nd year postgraduate student of the Department of therapy and polymorbid pathology named after academician M.S. Vovsi</p></bio><bio xml:lang="ru"><p>аспирант 2-го года обучения кафедры терапии и полиморбидной патологии им. академика М.С. Вовси</p></bio><email>dubinina_anna2023@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2988-1767</contrib-id><name-alternatives><name xml:lang="en"><surname>Mironova</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Миронова</surname><given-names>Елена Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD (Medicine), cardiologist, head of the Department of cardiology</p></bio><bio xml:lang="ru"><p>ассистент, старший лаборант кафедры терапии и полиморбидной патологии им. академика М.С. Вовси </p></bio><email>e.v.mironova@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-7241-0938</contrib-id><name-alternatives><name xml:lang="en"><surname>Filippova</surname><given-names>Tatiana V.</given-names></name><name xml:lang="ru"><surname>Филиппова</surname><given-names>Татьяна Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, assistant, senior laboratory assistant at the Department of therapy and polymorbid pathology named after academician M.S. Vovsi</p></bio><bio xml:lang="ru"><p>ассистент, старший лаборант кафедры терапии и полиморбидной патологии им. академика М.С. Вовси</p></bio><email>atv-tess@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0795-8225</contrib-id><contrib-id contrib-id-type="spin">3910-6585</contrib-id><name-alternatives><name xml:lang="en"><surname>Ostroumova</surname><given-names>Olga D.</given-names></name><name xml:lang="ru"><surname>Остроумова</surname><given-names>Ольга Дмитриевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), professor, head of the Department of therapy and polymorbid pathology named after academician M.S. Vovsi, professor of the Department of clinical pharmacology and propaedeutics of internal diseases</p></bio><bio xml:lang="ru"><p>д. м. н., профессор, заведующая кафедрой терапии и полиморбидной патологии им. академика М.С. Вовси, профессор кафедры клинической фармакологии и пропедевтики внутренних болезней</p></bio><email>ostroumova.olga@mail.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia.</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Central Clinical Hospital “RZhD-Medicine” </institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">I.M. Sechenov First Moscow Medical University of the Ministry of Healthcare of Russia (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-11-28" publication-format="electronic"><day>28</day><month>11</month><year>2024</year></pub-date><volume>10</volume><issue>9</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>130</fpage><lpage>139</lpage><history><date date-type="received" iso-8601-date="2025-01-23"><day>23</day><month>01</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-01-23"><day>23</day><month>01</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Bionika Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, ООО «Бионика Медиа»</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Bionika Media</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/646568">https://journals.eco-vector.com/2412-4036/article/view/646568</self-uri><abstract xml:lang="en"><p>Coronary heart disease (СHD) is a significant problem of modern medicine. Even with the increasing of the frequency of revascularization among patients with such type of disease, the necessity for antianginal therapy prescription remains to be high enough. According to clinical guidelines, two lines of drugs are indicated for the treatment of exertional angina. First-line drugs have anti-ischemic effect due to vasodilation or slowing of the heart rate, i.e. their efficacy is limited by the functional reserves of the myocardium during ischemia. The aim of the represented clinical analysis is to demonstrate the possibilities of a personalized approach to the management of exertional angina patients. Addition of prolonged-release trimetazidine in a single dose of 70 mg (Deprenorm<sup>®</sup> OD) 1 time per day to the ongoing antianginal therapy led to increase of the antianginal effect and improvement of life quality of the observed patient. A single dose of this medicine increases patient compliance with therapy, which allows us to consider its use as an optimal therapeutic option for СHD treatment.</p></abstract><trans-abstract xml:lang="ru"><p>Ишемическая болезнь сердца (ИБС) – значимая проблема современной медицины. Даже с увеличением частоты реваскуляризации среди пациентов с этим заболеванием потребность в антиангинальной терапии остается высокой. Согласно клиническим рекомендациям, для лечения стенокардии напряжения показано использование двух линий препаратов. Препараты первой линии оказывают антиишемическое действие за счет вазодилатации или урежения частоты сердечных сокращений, т. е. их эффект ограничен функциональными резервами миокарда во время ишемии. Цель представленного клинического разбора – продемонстрировать возможности персонализированного подхода к ведению пациентов со стенокардией напряжения. Добавление к проводимой антиангинальной терапии триметазидина с пролонгированнным действием для однократного приема 70 мг (препарат Депренорм<sup>®</sup> ОД) 1 р./сут. привело к усилению антиангинального эффекта и улучшению качества жизни наблюдавшегося больного. Однократный прием этого препарата повышает приверженность пациентов к терапии, что позволяет рассматривать его назначение в качестве оптимальной терапевтической опции при ИБС.</p></trans-abstract><kwd-group xml:lang="en"><kwd>coronary heart disease</kwd><kwd>exertional angina</kwd><kwd>polymorbidity</kwd><kwd>antianginal therapy</kwd><kwd>trimetazidine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ишемическая болезнь сердца</kwd><kwd>стенокардия напряжения</kwd><kwd>полиморбидность</kwd><kwd>антиангинальная терапия</kwd><kwd>триметазидин</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Roth G.A., Mensah G.A., Johnson C.O. et al.; GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group Global burden of cardiovascular diseases and risk factors, 1990–2019: Update from the GBD 2019 study. J Am Coll Cardiol. 2020; 76(25): 2982–3021. https://doi.org/.1016/j.jacc.2020.11.010. PMID: 33309175. 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