TherapyTherapyТерапия2412-40362713-1823Bionika Media64657510.18565/therapy.2024.9.152-162LECTURES & REPORTSЛЕКЦИИ & ДОКЛАДЫResearch ArticlePhenomenon of aging liver. Part I: Molecular-genetic, cellular, and tissue mechanismsФеномен стареющей печени. Часть 1: молекулярно-генетические, клеточные и тканевые механизмыhttps://orcid.org/0000-0002-4690-1811PrikhodkoVeronika A.ПриходькоВероника Александровна
Russian Federation

PhD (Biology), senior lecturer of the Department of pharmacology and clinical pharmacology

к. биол. н., старший преподаватель кафедры фармакологии и клинической фармакологии

veronika.prihodko@pharminnotech.comhttps://orcid.org/0000-0003-4294-5531OkovityiSergey V.ОковитыйСергей Владимирович
Russian Federation

MD, Dr. Sci. (Medicine), professor, head of the Department of pharmacology and clinical pharmacology of the, clinical and educational center for gastroenterology and hepatology

д. м. н., профессор, заведующий кафедрой фармакологии и клинической фармакологии, профессор Научно-клинического и образовательного центра гастроэнтерологии и гепатологии

sergey.okovity@pharminnotech.comSaint Petersburg State Chemical and Pharmaceutical University of the Ministry of Healthcare of RussiaФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава РоссииSaint Petersburg State Chemical and Pharmaceutical University of the Ministry of Healthcare of Russia, professor of the scientificФГБОУ ВО «Санкт-Петербургский государственный химико-фармацевтический университет» Минздрава РоссииSaint Petersburg State UniversityФГБОУ ВО «Санкт-Петербургский государственный университет»281120241091521622301202523012025Copyright ©; 2024, Bionika MediaCopyright ©; 2024, ООО «Бионика Медиа»2024Bionika MediaООО «Бионика Медиа»https://journals.eco-vector.com/2412-4036/article/view/646575

As the life expectancy of the world’s population increases, the medical and biological aspects of aging of both the body as a whole and individual organs are becoming increasingly important. The aim of the review is to summarize the literature data on numerous mechanisms and factors of liver aging at various levels of organization of living systems. The first part of the review contains information concerning molecular-genetic, cellular, and tissue changes that occur in liver during its natural aging.

По мере увеличения ожидаемой продолжительности жизни мирового населения все бóльшую актуальность приобретают медико-биологические аспекты старения как организма в целом, так и отдельных органов. Цель обзора – обобщить литературные данные о многочисленных механизмах и факторах старения печени на различных уровнях организации живых систем. В первой части обзора рассмотрены молекулярно-генетические, клеточные и тканевые изменения, происходящие в печени в ходе ее естественного старения.

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