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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">697930</article-id><article-id pub-id-type="doi">10.18565/therapy.2025.9.106-110</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Peculiarities of malaria caused by <italic>Plasmodium ovale</italic></article-title><trans-title-group xml:lang="ru"><trans-title>Особенности малярии, вызванной <italic>Plasmodium ovale</italic></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-0952-8295</contrib-id><name-alternatives><name xml:lang="en"><surname>Titov</surname><given-names>Vladislav D.</given-names></name><name xml:lang="ru"><surname>Титов</surname><given-names>Владислав Дмитриевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, resident physician</p></bio><bio xml:lang="ru"><p>врач-ординатор</p></bio><email>titoff.vlados@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8703-7671</contrib-id><name-alternatives><name xml:lang="en"><surname>Gopatsa</surname><given-names>Galina V.</given-names></name><name xml:lang="ru"><surname>Гопаца</surname><given-names>Галина Витальевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD (Medicine), head of the Department of infectious diseases No. 7, Infectious Diseases Clinical Hospital No. 1 of the Department of Healthcare of Moscow, senior researcher at the Clinical Department of infectious pathology, Central Research Institute of Epidemiology of Rospotrebnadzor</p></bio><bio xml:lang="ru"><p>к. м. н., заведующий инфекционным отделением № 7 ГБУЗ «Инфекционная клиническая больница № 1 Департамента здравоохранения г. Москвы», старший научный сотрудник клинического отдела инфекционной патологии ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора</p></bio><email>irinasemenova07@rambler.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6854-1722</contrib-id><name-alternatives><name xml:lang="en"><surname>Dzottsoeva</surname><given-names>Elina S.</given-names></name><name xml:lang="ru"><surname>Дзотцоева</surname><given-names>Элина Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD (Medicine), junior researcher at the Clinical Department of infectious pathology</p></bio><bio xml:lang="ru"><p>к. м. н., младший научный сотрудник клинического отдела инфекционной патологии</p></bio><email>sidelnicovaes@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6539-4878</contrib-id><name-alternatives><name xml:lang="en"><surname>Ponezheva</surname><given-names>Zhanna B.</given-names></name><name xml:lang="ru"><surname>Понежева</surname><given-names>Жанна Бетовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), head of the Clinical Department of infectious pathology</p></bio><bio xml:lang="ru"><p>д. м. н., заведующая клиническим отделом инфекционной патологии</p></bio><email>doktorim@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Central Research Institute of Epidemiology of Rospotrebnadzor</institution></aff><aff><institution xml:lang="ru">ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Infectious Diseases Clinical Hospital No. 1 of the Department of Healthcare of Moscow</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Инфекционная клиническая больница № 1 Департамента здравоохранения г. Москвы»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-12-06" publication-format="electronic"><day>06</day><month>12</month><year>2025</year></pub-date><volume>11</volume><issue>9</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>106</fpage><lpage>110</lpage><history><date date-type="received" iso-8601-date="2025-12-06"><day>06</day><month>12</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-12-06"><day>06</day><month>12</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, “Bionika Media” LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, ООО «Бионика Медиа»</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">“Bionika Media” LLC</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://journals.eco-vector.com/2412-4036/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/697930">https://journals.eco-vector.com/2412-4036/article/view/697930</self-uri><abstract xml:lang="en"><p>The actuality of malaria caused by Plasmodium ovale to Russian healthcare is persisting due to the steady increase of migration flows and rising of international tourism. Current article analyzes clinical and laboratory characteristics of malaria caused by this pathogen. A clinical observation of a 39-year-old patient hospitalized with cyclic fever, hepatomegaly, and intoxication syndrome is introduced. A key diagnostic advice during the patient’s examination was his epidemiological history – long-term residence in malaria-endemic regions (Cambodia, Uganda). This clinical case emphasizes the need to include malaria in the differential diagnosis row of the diseases for patients with fever who have traveled to endemic regions, even long after possible infection, due to the ability of P. ovale to persist in the body for a long time. Timely diagnosis and adequate therapy, including anti-hypnozoite drugs, are essential for preventing recurrences of the disease.</p></abstract><trans-abstract xml:lang="ru"><p>Актуальность проблемы малярии, вызванной Plasmodium ovale, для здравоохранения России обусловлена неуклонным ростом миграционных потоков и увеличением объемов международного туризма. В статье анализируются клинико-лабораторные особенности течения малярии, вызванной этим возбудителем. Представлено клиническое наблюдение пациента 39 лет, госпитализированного с цикличной лихорадкой, гепатомегалией и интоксикационным синдромом. Ключевой диагностической подсказкой в процессе его обследования стали данные эпидемиологического анамнеза – длительное проживание в эндемичных по малярии регионах (Камбоджа, Уганда). При рассмотрении приведенного клинического случая акцентируется внимание на необходимости включения малярии в дифференциально-диагностический ряд у пациентов с лихорадкой, побывавших в туристических поездках в эндемичных регионах, даже спустя длительное время после возможного инфицирования в связи со способностью P. ovale к длительной персистенции в организме. Своевременная диагностика и адекватная терапия, включающая препараты против гипнозоитов, являются обязательным условием для предотвращения рецидивов заболевания.</p></trans-abstract><kwd-group xml:lang="en"><kwd>malaria</kwd><kwd>fever</kwd><kwd>Plasmodium ovale</kwd><kwd>malaria treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>малярия</kwd><kwd>лихорадка</kwd><kwd>Plasmodium ovale</kwd><kwd>лечение малярии</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>World Health Organization. World malaria report 2023. 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