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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапия</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2412-4036</issn><issn publication-format="electronic">2713-1823</issn><publisher><publisher-name xml:lang="en">Bionika Media</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">707614</article-id><article-id pub-id-type="doi">10.18565/therapy.2026.3.93-97</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">A case of myxomatous degeneration of mitral valve leaflets complicated by chorda rupture</article-title><trans-title-group xml:lang="ru"><trans-title>Случай миксоматозной дегенерации створок митрального клапана, осложненной разрывом хорды</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1171-2746</contrib-id><contrib-id contrib-id-type="scopus">6506507539</contrib-id><contrib-id contrib-id-type="spin">7381-0612</contrib-id><name-alternatives><name xml:lang="en"><surname>Budnevsky</surname><given-names>Andrey V.</given-names></name><name xml:lang="ru"><surname>Будневский</surname><given-names>Андрей Валериевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor, Honored Inventor of the Russian Federation, Vice-Rector for Research and Innovation, Head of the Department of Faculty Therapy</p></bio><bio xml:lang="ru"><p>д. м. н., профессор, заслуженный изобретатель РФ, проректор по научно-инновационной деятельности, заведующий кафедрой факультетской терапии</p></bio><email>budnev@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-6419-5401</contrib-id><contrib-id contrib-id-type="spin">2300-7098</contrib-id><name-alternatives><name xml:lang="en"><surname>Grechkin</surname><given-names>Vyacheslav I.</given-names></name><name xml:lang="ru"><surname>Гречкин</surname><given-names>Вячеслав Иванович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD (Medicine), Associate Professor of the Department of Faculty Therapy</p></bio><bio xml:lang="ru"><p>к. м. н., доцент кафедры факультетской терапии</p></bio><email>grechkin.vi@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0297-1735</contrib-id><contrib-id contrib-id-type="scopus">56684358500</contrib-id><contrib-id contrib-id-type="spin">8452-1318</contrib-id><name-alternatives><name xml:lang="en"><surname>Kravchenko</surname><given-names>Andrey Y.</given-names></name><name xml:lang="ru"><surname>Кравченко</surname><given-names>Андрей Яковлевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor of the Department of Faculty Therapy</p></bio><bio xml:lang="ru"><p>д. м. н., профессор кафедры факультетской терапии</p></bio><email>drkay@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8984-1831</contrib-id><contrib-id contrib-id-type="scopus">58096896200</contrib-id><contrib-id contrib-id-type="spin">1432-9076</contrib-id><name-alternatives><name xml:lang="en"><surname>Pertsev</surname><given-names>Alexander V.</given-names></name><name xml:lang="ru"><surname>Перцев</surname><given-names>Александр Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD (Medicine), Associate Professor of the Department of Faculty Therapy</p></bio><bio xml:lang="ru"><p>к. м. н., доцент кафедры факультетской терапии</p></bio><email>pertsev.vrn@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">N.N. Burdenko Voronezh State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-05-21" publication-format="electronic"><day>21</day><month>05</month><year>2026</year></pub-date><volume>12</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>93</fpage><lpage>97</lpage><history><date date-type="received" iso-8601-date="2026-05-19"><day>19</day><month>05</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-05-19"><day>19</day><month>05</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, “Bionika Media” LLC</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, ООО «Бионика Медиа»</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">“Bionika Media” LLC</copyright-holder><copyright-holder xml:lang="ru">ООО «Бионика Медиа»</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/2412-4036/article/view/707614">https://journals.eco-vector.com/2412-4036/article/view/707614</self-uri><abstract xml:lang="en"><p>Acute mitral valve insufficiency is a common condition encountered by physicians of various specialties, including cardiologists, therapists, rheumatologists, and cardiac surgeons. The underlying causes of the disease are varied, and the severity of the condition, caused by the development of acute left ventricular failure, requires early diagnosis and urgent care, including surgical intervention. Current article presents a clinical case of myxomatous degeneration of the mitral valve leaflets in a 41-year-old patient, complicated by chordal rupture with the development of acute mitral regurgitation, which resulted in death.</p></abstract><trans-abstract xml:lang="ru"><p>Острая недостаточность митрального клапана – нередкая патология, с которой сталкиваются врачи различных специальностей: кардиологи, терапевты, ревматологи, кардиохирурги. В основе заболевания лежат различные причины, а тяжесть состояния, обусловленная развитием острой левожелудочковой недостаточности, требует ранней диагностики и оказания срочной, в том числе хирургической, помощи. В статье представлен клинический случай миксоматозной дегенерации створок митрального клапана у пациента 41 года, осложненной разрывом хорды с развитием острой митральной недостаточности, который закончился летальным исходом.</p></trans-abstract><kwd-group xml:lang="en"><kwd>mitral valve chordal rupture</kwd><kwd>mitral regurgitation</kwd><kwd>clinical case</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>отрыв хорды митрального клапана</kwd><kwd>митральная регургитация</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Андрияшкина Д.Ю., Демидова Н.А., Гевондян К.Р., Клименко А.А. Митральная регургитация: причины и механизмы развития, диагностика и исходы. Рациональная фармакотерапия в кардиологии. 2025;21(3):281–288. [Andriashkina DYu, Demidova NA, Gevondyan KR, Klimenko AA. Mitral regurgitation: Causes and mechanisms of development, diagnostics, and outcomes. 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