Patient with comorbidity. Pathogenetic principles of antimicrobial treatment of urinary tract infections in diabetic patients


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Abstract

Urinary tract infections (UTIs) are a fairly heterogeneous group of diseases, which is very common and is second only to acute respiratory infections on prevalence after according to some data. The spectrum of these pathologies can vary from spontaneously resolving cystitis (or even asymptomatic bacteriuria) to a life-threatening septic syndrome. The lecture discusses the classification, epidemiology, pathogenesis, and antibacterial therapy of UTIs. Due to the fact that patients with diabetes mellitus (DM) represent a separate group of high risk for UTIs, the features of clinical variants of UTIs in DM, epidemiological features, and features of antimicrobial therapy of UTIs in diabetic patients are mentioned in the lecture.

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About the authors

Ivan G. Kayukov

I.P. Pavlov First Saint Petersburg state medical university

Email: kaukov0nephrologia.ru
MD, professor, Department of nephrology and dialysis of the faculty of postgraduate education

Ashot M. Yesayan

I.P. Pavlov First Saint Petersburg state medical university

MD, professor, head of the Department of nephrology and dialysis of the faculty of postgraduate education

References

  1. Ушкалова Е.А. Фторхинолоны в лечении инфекций мочевыводящих путей: современное состояние вопроса. Фарматека. 2005;16:15-22. [Ushkalova Ye.A. Fluoroquinolones in the treatment of urinary tract infections: the current state of the issue. Pharmateca. 2005;16:15-22 (in Russ.)]
  2. Ejrnæs K. Bacterial characteristics of importance for recurrent urinary tract infections caused by Escherichia coli. Dan. Med. Bull. 2011;58(4):4187.
  3. Hisano M., Bruschini H., Nicodemo A.C., Srougi M. Cranberries and lower urinary tract infection prevention. Clinics (Sao Paulo). 2012;67(6):661-8.
  4. Fünfstück R., Nicolle L.E., Hanefeld M., Naber K.G. Urinary tract infection in patients with diabetes mellitus. Clin. Nephrol. 2012;77(1):40-8.
  5. Brown J.S., Wessells H., Chancellor M.B., Howards S.S., Stamm W.E., Stapleton A.E., Steers W.D., Van Den Eeden S.K., McVary K.T. Urologic complications of diabetes. Diabetes Care. 2005;28(1):177-85.
  6. Grabe M., Bartoletti R., Bjerklund Johansen T.E. et al. Guidelines on urological infections. 2015 (http://uroweb.org/wp-content/ uploads/19-Urological-infections_LR2.pdf).
  7. Mnif M.F., Kamoun M., Kacem F.H., Bouaziz Z., Charfi N., Mnif F., Naceur B.B., Rekik N., Abid M. Complicated urinary tract infections associated with diabetes mellitus: pathogenesis, diagnosis and management. Indian J. Endocrinol. Metab. 2013;17(3):442-5.
  8. Nitzan O., Elias M., Chazan B., Saliba W. Urinary tract infections in patients with type 2 diabetes mellitus: review of prevalence, diagnosis, and management. Diabetes Metab. Syndr. Obes. 2015;8:129-36.
  9. Yu S., Fu A.Z., Qiu Y., et al. Disease burden of urinary tract infections among type 2 diabetes mellitus patients in the US. J. Diabetes Complications. 2014;28(5):621-6.
  10. Foxman B. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Dis. Mon. 2003;49(2):53-70.
  11. Лопаткин Н.А., Мартов А.Г. Состояние и перспективы развития урологической помощи в Российской федерации. Материалы X Всероссийского съезда урологов. М., 2002:5-30. [Lopatkin N.A. Martov A.G. Status and prospects of development of urological care in the Russian Federation. Proceedings of X Congress of urologists of Russia. Moscow, 2002:5-30 (in Russ.)]
  12. Лоран О.Б. Эпидемиологические аспекты инфекций мочевыводящих путей. Материалы международного симпозиума «Инфекции мочевыводящих путей у амбулаторных больных». М., 1999:5-8. [Loran O.B. Epidemiological aspects of urinary tract infections. Proceedings of the International symposium «Urinary tract infection in outpatients». Moscow, 1999:5-8 (in Russ.)]
  13. Hirji I., Guo Z., Andersson S.W., Hammar N., Gomez-Caminero A. Incidence of urinary tract infection among patients with type 2 diabetes in the UK General Practice Research Database (GPRD). J. Diabetes Complications. 2012;26(6):513-6.
  14. Hammar N., Farahmand B., Gran M., Joelson S., Andersson S.W. Incidence of urinary tract infection in patients with type 2 diabetes. Experience from adverse event reporting in clinical trials. Pharmacoepidemiol. Drug Saf. 2010;19(12):1287-92.
  15. Fu A.Z., Iglay K., Qiu Y., Engel S., Shankar R., Brodovicz K. Risk characterization for urinary tract infections in subjects with newly diagnosed type 2 diabetes. J. Diabetes Complications. 2014;28(6):805-10.
  16. Colgan R., Nicolle L.E., McGlone A., Hooton T.M. Asymptomatic bacteriuria in adults. Am. Fam. Physician. 2006;74(6):985-90.
  17. Nicolle L.E. Asymptomatic bacteriuria. Curr. Opin. Infect. Dis. 2014;27(1):90-6.
  18. Renko M., Tapanainen P., Tossavainen P., Pokka T., Uhari M. Meta-analysis of the significance of asymptomatic bacteriuria in diabetes. Diabetes Care. 2011;34(1):230-5.
  19. Aswani S.M., Chandrashekar U., Shivashankara K., Pruthvi B. Clinical profile of urinary tract infections in diabetics and nondiabetics. Australas. Med. J. 2014;7(1):29-34.
  20. Scholes D., Hooton T.M., Roberts P.L., Gupta K., Stapleton A.E., Stamm W.E. Risk factors associated with acute pyelonephritis in healthy women. Ann. Intern. Med. 2005;142(1):20-7.
  21. Nicolle L.E., Friesen D., Harding G.K., Roos L.L. Hospitalization for acute pyelonephritis in Manitoba, Canada, during the period from 1989 to 1992; impact of diabetes, pregnancy, and aboriginal origin. Clin. Infect. Dis. 1996;22(6):1051-6.
  22. Benfield T., Jensen J.S., Nordestgaard B.G. Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia. 2007;50(3):549-54.
  23. Bilo H.J. Susceptibility to infection in patients with diabetes mellitus. Ned. Tijdschr. Geneeskd. 2006;150(10):533-4 (in Dutch).
  24. Wen S.C., Juan Y.S., Wang C.J., Chang K., Shih M.C., Shen J.T., Wu W.J., Jang M.Y. Emphysematous prostatic abscess: case series study and review. Int. J. Infect. Dis. 2012;16(5):e344-e349.
  25. Cegelski L., Marshall G.R., Eldridge G.R., Hultgren S.J. The biology and future prospects of antivirulence therapies. Nat. Rev. Microbiol. 2008;6(1):17-7.
  26. Garofalo C.K., Hooton T.M., Martin S.M., Stamm W.E., Palermo J.J., Gordon J.I., Hultgren S.J. Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation. Infect. Immun. 2007;75(1):52-60.
  27. Russo T.A., Stapleton A., Wenderoth S., Hooton T.M., Stamm W.E. Chromosomal restriction fragment length polymorphism analysis of Escherichia co/istrains causing recurrent urinary tract infections in young women. J. Infect. Dis. 1995;172(2):440-5.
  28. Manges A.R., Tabor H., Tellis P., Vincent C., Tellier P.P. Endemic and epidemic lineages of Escherichia coli that cause urinary tract infections. Emerg. Infect. Dis. 2008;14(10):1 575-83.
  29. Foxman B., Manning S.D., Tallman P., Bauer R., Zhang L., Koopman J.S., Gillespie B., Sobel J.D., Marrs C.F. Uropathogenic Escherichia coli are more likely than commensal E coli to be shared between heterosexual sex partners. Am. J. Epidemiol. 2002;156(12):1 133-40.
  30. Chatterjee S., Chaudhury S., McShan A.C., Kaur K., De Guzman R.N. Structure and biophysics of type III secretion in bacteria. Biochemistry. 2013;52(15):2508-17.
  31. Alteri C.J., Mobley H.L. Escherichia coli physiology and metabolism dictates adaptation to diverse host microenvironments. Curr. Opin. Microbiol. 2012;15(1):3-9
  32. Silverman J.A., Schreiber H.L. 4th, Hooton T.M., Hultgren S.J. From physiology to pharmacy: developments in the pathogenesis and treatment of recurrenturinary tract infections. Curr. Urol. Rep. 2013;14(5):448-56.
  33. Vandewalle A. Toll-like receptors and renal bacterial infections. Chang Gung Med J. 2008;31(6):525-37.
  34. Robson M.G. Toll-like receptors and renal disease. Nephron. Exp. Nephrol. 2009;113(1):e1-7.
  35. Gonçalves G.M., Castoldi A., Braga T.T., Câmara N.O. New roles for innate immune response in acute and chronic kidney injuries. Scand. J. Immunol. 2011;73(5):428-35.
  36. Wang M.C., Tseng C.C., Wu A.B., Lin W.H., Teng C.H., Yan J.J., Wu J.J. Bacterial characteristics and glycemic control in diabetic patients with Escherichia coliurinary tract infection. J. Microbiol. Immunol. Infect. 2013;46(1):24-9.
  37. Boyko E.J., Fihn S.D., Scholes D., Abraham L., Monsey B. Risk of urinary tract infection and asymptomatic bacteriuria among diabetic and nondiabetic postmenopausal women. Am. J. Epidemiol. 2005;161(6):557-64.
  38. Schneeberger C., Kazemier B.M., Geerlings S.E. Asymptomatic bacteriuria and urinary tract infections in special patient groups: women with diabetes mellitus and pregnant women. Curr. Opin. Infect. Dis. 2014;27(1):108-14.
  39. Geerlings S.E., Brouwer E.C., van Kessel K.C, Gaastra W., Stolk R.P., Hoepelman A.I. Cytokine secretion is impaired in women with diabetes mellitus. Eur. J. Clin. Invest. 2000;30(11):995-1001.
  40. Kaplan S.A., Te A.E., Blaivas J.G. Urodynamic findings in patients with diabetic cystopathy. J. Urol. 1995;153(2):342-4.
  41. Al-Rubeaan K.A., Moharram O., Al-Naqeb D., Hassan A., Rafiullah M.R. Prevalence of urinary tract infection and risk factors among Saudi patients with diabetes. World J. Urol. 2013;31(3):573-8.
  42. Yang X.P., Lai D., Zhong X.Y., Shen H.P., Huang Y.L. Efficacy and safety of canagliflozin in subjects with type 2 diabetes: systematic review and meta-analysis. Eur. J. Clin. Pharmacol. 2014;70(10):1149-58.
  43. Ptaszynska A., Johnsson K.M., Parikh S.J., de Bruin T.W., Apanovitch A.M., List J.F. Safety profile of dapagliflozin for type 2 diabetes: pooled analysis of clinical studies for overall safety and rare events. Drug Saf. 2014;37(10):815-29.
  44. Палагин И.С. Современные аспекты выбора антимикробных препаратов при острых неосложненных циститах. Клин. микробиол. антимикроб. химиотер. 2009;11(4);327-34. [Palagin I.S. Modern aspects of the choice of antimicrobial drugs for acute uncomplicated cystitis. Clin. Microbiol. Antimicrob. Chemiother. 2009;11(4);327-34 (in Russ.)]
  45. Zalmanovici Trestioreanu A., Green H., Paul M., Yaphe J., Leibovici L. Antimicrobial agents for treating uncomplicated urinary tract infection in women. Cochrane Database Syst Rev. 2010;(10):CD007182
  46. Nicolle L.E. Short-term therapy for urinary tract infection: success and failure. Int. J. Antimicrob. Agents. 2008;31 (Suppl. 1):S40-45.
  47. Лопаткин Н.А., Аполихин О.И., Пушкарь Д.Ю., Камалов А.А., Перепановa Т.С. Российские национальные рекомендации «Антимикробная терапия и профилактика инфекций почек, мочевыводящих путей и мужских половых органов». М., 2014. 64 c. [Lopatkin N.A., Apolikhin O.I., Pushkar D.Yu., Kamalov A.A., Perepanova T.S. Russian national recommendations «Antimicrobial therapy and prevention of infections of kidneys, urinary tracts and male genital organs». Moscow, 2014. 64 p. (in Russ.)]
  48. Meiland R., Geerlings S.E., Stolk R.P., Netten P.M., Schneeberger P.M., Hoepelman A.I. Asymptomatic bacteriuria in women with diabetes mellitus: effect on renal function after 6 years of follow-up. Arch. Intern. Med. 2006;166(20):2222-7.
  49. Nicolle L.E., Zhanel G.G., Harding G.K. Microbiological outcomes in women with diabetes and untreated asymptomatic bacteriuria. World J. Urol. 2006;24(1):61-5.
  50. Harding G.K., Zhanel G.G., Nicolle L.E., Cheang M.; Manitoba diabetes urinary tract infection study group. Antimicrobial treatment in diabetic women with asymptomatic bacteriuria. N. Engl. J. Med. 2002;347(20):1576-83.
  51. Gupta K., Hooton T.M., Naber K.G., et al. Infectious Diseases Society of America; European Society for Microbiology and Infectious Diseases International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin. Infect. Dis. 2011;52(5):e103-e120.
  52. Hooton T.M., Bradley S.F., Cardenas D.D., et al. Infectious Diseases Society of America Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin. Infect. Dis. 2010;50(5):625-63.

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