Damage to the digestive organs in COVID-19: current state of the problem
- Authors: Osadchuk A.M.1, Loranskaya I.D.1, Osadchuk M.A.2, Stepanova E.V.1, Parusov A.I.1
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Affiliations:
- Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia
- I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
- Issue: Vol 7, No 4 (2021)
- Pages: 72-80
- Section: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/288205
- DOI: https://doi.org/10.18565/therapy.2021.4.72-80
- ID: 288205
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Abstract
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About the authors
Alexey M. Osadchuk
Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia
Email: a.m.osadchuk2020@mail.ru
MD, professor, professor of the Department of gastroenterology 123242, Moscow, 2/1 Barrikadnaya Str
Irina D. Loranskaya
Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia
Email: gastromapo@yandex.ru
MD, professor, head of the Department of gastroenterology 123242, Moscow, 2/1 Barrikadnaya Str
Mikhail A. Osadchuk
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Email: mikhail@yandex.ru
MD, professor, head of the Department of outpatient therapy 119435, Moscow, 2/9 Bol'shaya Pirogovskaya Str
Elena V. Stepanova
Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia
Email: gmunden2011@yandex.ru
PhD, associate professor, associate professor of the Department of gastroenterology 123242, Moscow, 2/1 Barrikadnaya Str
Andrey I. Parusov
Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia
Email: andre_webster@mail.ru
assistant of the Department of gastroenterology 123242, Moscow, 2/1 Barrikadnaya Str
References
- Fontanesi L., Marchetti D., Mazza C. et al. The effect of the COVID-19 lockdown on parents: A call to adopt urgent measures. Psychol Trauma. 2020; 12(S1): S79-S81. doi: 10.1037/tra0000672.
- Mazza C., Ricci E., Marchetti D. et al. How personality relates to distress in parents during the Covid-19 lockdown: The mediating role of child's emotional and behavioral difficulties and the moderating effect of living with other people. Int J Environ Res Public Health. 2020; 17(17): 6236. doi: 10.3390/ijerph17176236.
- Di Crosta A., Palumbo R., Marchetti D. et al. Individual differences, economic stability, and fear of contagion as risk factors for PTSD symptoms in the COVID-19 emergency. Front Psychol. 2020; 11: 567367. doi: 10.3389/fpsyg.2020.567367.
- Зольникова О.Ю., Джахая Н.Л., Поцхверашвили Н.Д. с соавт. Клинические особенности пациентов с SARS-CoV-2-инфекцией. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2020; 6: 28-39. doi: https://dx.doi.org/10.22416/1382-4376-2020-30-6-28-39.
- Walker M. Chronic liver conditions raise risk of death in COVID-19 patients. MedPage Today. November 16, 2020. URL: https://www.medpagetoday.com/meetingcoverage/aasld/89710 (date of access - 02.04.2020).
- Jin X., Lian J.S., Hu J.H. et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020; 69(6): 1002-09. doi: 10.1136/gutjnl-2020-320926.
- Pan L., Mu M., Yang P. et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive cross-sectional multicenter study. Am J Gastroenterol. 2020; 115(5): 766-73. doi: 10.14309/ajg.0000000000000620.
- Cheung K.S., Ivan F.N., Hung M.D. et al. Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from a Hong Kong cohort: systematic review and meta-analysis. Gastroenterology. 2020; 159(1): 81-95. doi: 10.1053/j.gastro.2020.03.065.
- D'Amico F., Baumgart D.C., Danese S., Peyrin-Biroulet L. Diarrhea during COVID-19 infection: Pathogenesis, epidemiology, prevention, and management. Clin Gastroenterol Hepatol. 2020; 18(8): 1663-72. doi: 10.1016/j.cgh.2020.04.001.
- Docherty A.B., Harrison E.M., Green C.A. et al. ISARIC4C investigators. Features of 20,133 UK patients in hospital with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020; 369: m1985. doi: 10.1136/bmj. m1985.
- Argenziano M.G., Bruce S.L., Slater C.L. et al. Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series. BMJ. 2020; 369: m1996. doi: 10.1136/bmj.m1996.
- Arjmand B., Ghorbani F., Koushki M. et al. Gastrointestinal symptoms in patients with mild and severe COVID-19: a scoping review and meta-analysis. Gastroenterol Hepatol Bed Bench. 2020; 13(4): 321-30.
- Andrews P.L.R., Cai W., Rudd J.A., Sanger G.J. COVID-19, nausea, and vomiting. J Gastroenterol Hepatol. 2021; 36(3): 646-56. doi: 10.1111/jgh.15261.
- Al-Ani R.M., Acharya D. Prevalence of anosmia and ageusiain patients with COVID-19 at primary Health Center, Doha, Qatar. Indian J Otolaryngol Head Neck Surg. 2020: 1-7. doi: 10.1007/s12070-020-02064-9.
- Hunt R.H., East J.E., Lanas A. et al. COVID-19 and gastrointestinal disease: Implications for the gastroenterologist. Dig Dis. 2021; 39(2): 119-39. doi: 10.1159/000512152.
- Rokkas T. Gastrointestinal involvement in COVID-19: a systematic review and meta-analysis. Ann Gastroenterol. 2020; 33(4): 355-65. doi: 10.20524/aog.2020.0506.
- Han C., Duan C., Zhang S. et al. Digestive symptoms in COVID-19 patients with mild disease severity: clinical presentation, stool viral RNA testing, and outcomes. Am J Gastroenterol. 2020; 115(6): 916-23. doi: 10.14309/ajg.0000000000000664.
- Parasa S., Desai M., Chandrasekar V.T. et al. Prevalence of gastrointestinal symptoms and fecal viral shedding in patients with coronavirus disease 2019: A systematic review and meta-analysis. JAMA Netw Open. 2020; 3(6): e2011335. doi: 10.1001/jamanetworkopen.2020.11335.
- Garrido I., Liberal R., Macedo G. COVID-19 and liver disease-what we know on 1st May 2020. Aliment Pharmacol Ther. 2020; 52(2): 267-75. doi: 10.1111/apt.15813.
- Cai Q., Huang D., Yu H.et al. COVID-19: Abnormal liver function tests. J Hepatol. 2020; 73: 566-74. doi: 10.1016/j.jhep.2020.04.006.
- Gadour E., Hassan Z., Shrwani K. Covid-19 induced hepatitis (CIH), definition and diagnostic criteria of a poorly understood new clinical syndrome. Gut 2020; 69 (Suppl 1): A1-A51. doi: 10.47690/WJGHE.2020.3301.
- Wang Y., Liu S., Liu H. et al. SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19. J Hepatol. 2020; 73: 807-16.doi: 10.1016/j.jhep.2020.05.002.
- Boettler T., Marjot T., Newsome P.N. et al. Impact of COVID-19 on the care of patients with liver disease: EASL-ESCMID position paper after 6 months of the pandemic. JHEP Rep. 2020; 2(5): 100169. doi: 10.1016/j.jhepr.2020.100169.
- Vespa E., Pugliese N., Piovani D. et al. Liver tests abnormalities in COVID-19: trick or treat?. J Hepatol. 2020; 73(5): 1275-76. doi: 10.1016/j.jhep.2020.05.033.
- Kumar A., Kumar P., Dungdung A. et al. Pattern of liver function and clinical profile in COVID-19: A cross-sectional study of 91 patients. Diabetes Metab Syndr. 2020; 14(6): 1951-54. doi: 10.1016/j.dsx.2020.10.001.
- Zuo T., Liu Q., Zhang F. et al. Depicting SARSCoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19. Gut. 2021; 70: 276-84. doi: 10.1136/gutjnl-2020-322294.
- Massironi S., Vigano C., Dioscoridi L. et al. Endoscopic findings in patients infected with 2019 novel coronavirus in Lombardy, Italy. Clin Gastroenterol Hepatol. 2020; 18(10): 2375-77. doi: 10.1016/j.cgh.2020.05.045.
- Inamdar S., Benias P.C., Liu Y. et al. Prevalence, risk factors, and outcomes of hospitalized patients with COVID-19 presenting as acute pancreatitis. Gastroenterology. 2020; 159(6): 2226-28.e2. doi: 10.1053/j.gastro.2020.08.044.
- Wang F., Wang H., Fan J. et al. Pancreatic injury patterns in patients with coronavirus disease 19 pneumonia. Gastroenterology. 2020; 159(1): 367-70. doi: 10.1053/j.gastro.2020.03.055.
- Tositti G., Fabris P., Barnes E.et al. Pancreatic hyperamylasemia during acute gastroenteritis: incidence and clinical relevance. BMC Infect Dis. 2001; 1(1): 18. doi: 10.1186/1471-2334-1-18.
- Dirweesh A., Li Y., Trikudanathan G. et al. Clinical outcomes of acute pancreatitis in patients with coronavirus disease 2019. Gastroenterology 2020; 159: 1972-74. doi: 10.1053/j.gastro.2020.07.038.
- Balaphas A., Gkoufa K., Meyer J. et al. Covid-19 can mimic acute cholecystitis and is associated with the presence of viral RNA in the gallbladder wall. J Hepatol. 2020; 73(6): 1566-68. doi: 10.1016/j.jhep.2020.08.020.
- Xiao F., Tang M., Zheng X. et al. Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020; 158(6): 1831-33.e3. doi: 10.1053/j.gastro.2020.02.055.
- Connors J.M., Levy J.H. COVID-19 and its implications for thrombosis and anticoagulation. Blood. 2020; 135(23): 2033-40. doi: 10.1182/blood.2020006000.
- Lanas A., Dumonceau J.M., Hunt R.H. et al. Non-variceal upper gastrointestinal bleeding. Nat Rev Dis Primers. 2018; 4: 18020. doi: 10.1038/nrdp.2018.20.
- Zuo T., Zhang F., Lui G.C.Y. et al. Alterations in gut microbiota of patients with COVID-19 during time of hospitalization. Gastroenterology. 2020; 159(3): 944-55.e8. doi: 10.1053/j.gastro.2020.05.048.
- Pan Y., Zhang D., Yang P. et al. Viral load of SARS-CoV-2 in clinical samples. Lancet Infect Dis. 2020; 20(4): 411-12. doi: 10.1016/ S1473-3099 (20) 30113-4.
- Huizen J. (Fact checked by Alexandra Sanfins, Ph.D.) Gastrointestinal symptoms in COVID-19: What we know so far and why it is important. Medical News Today. 12 February 2021. URL: https://www.medicalnewstoday.com/articles/gastrointestinal-symptoms-in-covid-19-what-do-we-know-so-far (date of access - 02.04.2021).
- Yang X., Yu Y., Xu J. et al. Clinical course and outcomes of critically ill patients with SARSCoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020; 8(5): 475-81. doi: 10.1016/S2213-2600(20)30079-5.
- Chan K.H., Lim S.L., Damati A. et al. Coronavirus disease 2019 (COVID-19) and ischemic colitis: An under-recognized complication. Am J Emerg Med. 2020; 38(12): 2758.e1-2758.e4. doi: 10.1016/j.ajem.2020.05.072.
- Levi M., Thachil J., Iba T., Levy J.H. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol. 2020; 7(6): e438-40. doi: 10.1016/S2352-3026(20)30145-9.
- Farina D., Rondi P., Botturi E. et al. Gastrointestinal: bowel ischemia in a suspected coronavirus disease (COVID-19) patient. J J Gastroenterol Hepatol. 2021; 36(1): 41. doi: 10.1111/jgh.15094.
- Tian Y., Rong L., Nian W. Gastrointestinal features in COVID-19 and the possibility of faecal transmission. Aliment Pharmacol Ther. 2020;51:843-51.
- Muus C., Luecken M.D., Eraslan G. et al. Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells. bioRxiv. 2020: 2020.04.19.049254. doi: 10.1101/2020.04.19.049254.
- Hoffmann M., Kleine-Weber H., Schroeder S. et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181(2): 271-80.e8. doi: 10.1016/j.cell.2020.02.052.
- Yang L., Han Y., Nilsson-Payant B.E. et al. A human pluripotent stem cell-based platform to study SARSCoV-2 tropism and model virus infection in human cells and organoids. Cell Stem Cell. 2020; 27(1): 125-136.e7. doi: 10.1016/j.stem.2020.06.015.
- Iavarone M., D'Ambrosio R., Soria A. et al. High rates of 30-day mortality in patients with cirrhosis and COVID-19. J Hepatol. 2020; 73(5): 1063-71. doi: 10.1016/j.jhep.2020.06.001.
- Puelles V.G., Lutgehetmann M., Lindenmeyer M.T. et al. Multiorgan and renal tropism of SARS-CoV-2. N Engl J Med. 2020; 383(6): 590-92. doi: 10.1056/NEJMc2011400.
- Wichmann D., Sperhake J.P., Lutgehetmann M. et al. Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med. 2020; 173(4): 268-77. doi: 10.7326/M20-2003.
- Tian S., Xiong Y., Liu H. et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Mod Pathol. 2020; 33(6): 1007-14. doi: 10.1038/s41379-020-0536-x.
- Bangash M.N., Patel J.M., Parekh D. et al. SARSCoV-2: is the liver merely a bystander to severe disease? J Hepatol. 2020; 73(4): 995-96. doi: 10.1016/j.jhep.2020.05.035.
- Chai X., Hu L., Zhang Y. et al. Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. bioRxiv. 2020.02.03.931766. doi: 10.1101/2020.02.03.931766.
- Zhang C., Shi L., Wang F.S. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020; 5(5): 428-30. doi: 10.1016/S2468-1253(20)30057-1.
- Anand S., Mande S.S. Diet, microbiota and gut-lung connection. Front Microbiol. 2018; 9: 2147. doi: 10.3389/fmicb.2018.02147.
- Groves H.T., Higham S.L., Moffatt M.F. et al. Respiratory viral infection alters the gut microbiota by inducing inappetence. MBio. 2020; 11(1): e03236-19. doi: 10.1128/mBio.03236-19.
- Gu S., Chen Y., Wu Z. et al. Alterations of the gut microbiota in patients with COVID-19 or H1N1 influenza. Clin Infect Dis. 2020; 71(10): 2669-78. doi: 10.1093/cid/ciaa709.
- Hu Y., Lu G.-Z., Xu J. Discussion on symptoms of digestive tract caused by novel coronavirus infection. Chinese J Infect Dis 38: 2020. doi: 10.3760/cma.j.cn311365-20200220-00094.
- Zeng J., Wang C.T., Zhang F.S. et al. Effect of probiotics on the incidence of ventilator-associated pneumonia in critically ill patients: a randomized controlled multicenter trial. Intensive Care Med. 2016; 42(6): 1018-28. doi: 10.1007/s00134-016-4303-x.
- Brenner E.J., Ungaro R.C., Colombel J.F. et al. SECURE-IBD data base public data update [cited 2020 Sep 9]. Available from: covidibd. org (date of access - 02.04.2021).
- van Paassen J., Vos J.S., Hoekstra E.M. et al. Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes. Crit Care. 2020; 24(1): 696. doi: 10.1186/s13054-020-03400-9.
- Brain O., Satsangi J. Therapeutic decisions in inflammatory bowel disease in the SARS-CoV-2 pandemic. 2020; 15: S0016-5085(20)34775-2. doi: 10.1053/j.gastro.2020.05.083.
- Cai Q., Huang D., Yu H. et al. COVID-19: Abnormal liver function tests. Journal of Hepatology. 2020; 73: 566-74. doi: 10.1016/j.jhep.2020.04.006.
- Lerch M.M., Saluja A.K., Dawra R. et al. The effect of chloroquine dministration on two experimental models of acute pancreatitis. Gastroenterology. 1993; 104(6): 1768-79. doi: 10.1016/0016-5085(93)91022-a.
- Frommeyer G., Fischer C., Ellermann C. et al. Severe proarrhythmic potential of the antiemetic agents ondansetron and domperidone. Cardiovasc Toxicol. 2017; 17(4): 451-57. doi: 10.1007/s12012-017-9403-5.
- Lee S.W., Ha E.K., Yeniova A.O. et al. Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching. Gut. 2021; 70(1):76-84. doi: 10.1136/gutjnl-2020-322248.
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