Clinical and immunological peculiarities of ARVI in patients with concomitant allergic rhinitis in remission
- 作者: Ponezheva L.O.1, Turapova A.N.2, Mannanova I.V.2, Alakaev R.Z.3, Vyzhlova E.N.4, Bragina G.S.4, Kalyuzhin O.V.1
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隶属关系:
- I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
- Central Research Institute of Epidemiology of Rospotrebnadzor
- Institute of Dentistry and Maxillofacial Surgery of Kh.M. Berbekov Kabardino-Balkarian State University
- National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Healthcare of Russia
- 期: 卷 10, 编号 7 (2024)
- 页面: 50-57
- 栏目: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/637467
- DOI: https://doi.org/10.18565/therapy.2024.7.50-57
- ID: 637467
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详细
Combination of acute respiratory viral infection (ARVI) and allergy is characterized by a complex interaction and mutual influence of two pathological processes.
The aim: to find clinical and immunological peculiarities of seasonal ARVI in patients with concomitant allergic rhinitis (AR) in the remission stage, to determine the efficacy of various drug therapy options in such kind of patients.
Material and methods. 88 patients with uncomplicated ARVI were involved in the study. Group 1 included 32 persons with ARVI and seasonal AR who received recombinant interferon alpha-2b (IFN- α-2b) with antioxidants (VIFERON®). The same treatment regimen was received by the 2nd group of 29 patients with ARVI without allergy. Group 3 included 27 persons with ARVI without allergy who used umifenovir. The control group consisted of 30 conditionally healthy individuals.
Results. Concentration of IFN-α in the blood serum and the proportion of cells expressing CD118+ among peripheral blood lymphocytes in patients with ARVI + AR before treatment significantly exceeded this index in conditionally healthy patients. In patients with ARVI without allergy, the level of induced IFN-α production was significantly higher than in conditionally healthy patients and patients with ARVI and AR. After treatment, in both groups, concentration of serum and induced IFN-α decreased to the conditional norm, there was a tendency for increasing the levels of CD118+ and CD119+.
Conclusion. In the early stages of ARVI development, patients with AR in remission were found to have a decreased ability of blood cells to produce IFN types I and II in response to stimulation comparatively to patients without allergy. Comparison of the clinical efficacy of two treatment options in patients with ARVI revealed that the combination of nasal and rectal forms of recombinant IFN-α-2b with antioxidants (VIFERON®) is more effective than use of umifenovir in stopping clinical manifestations of ARVI in the presence of almost identical virological efficacy.
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作者简介
Liana Ponezheva
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
编辑信件的主要联系方式.
Email: ponejevaliana@gmail.com
ORCID iD: 0000-0001-9459-8143
MD, postgraduate student of the Department of clinical immunology and allergology
俄罗斯联邦, MoscowAlexandra Turapova
Central Research Institute of Epidemiology of Rospotrebnadzor
Email: alyaspid@gmail.com
ORCID iD: 0000-0002-2893-0854
MD, PhD (Medicine), researcher at the Clinical Department of infectious pathology
俄罗斯联邦, MoscowIrina Mannanova
Central Research Institute of Epidemiology of Rospotrebnadzor
Email: irinasemenova07@rambler.ru
ORCID iD: 0000-0003-2244-8810
SPIN 代码: 2975-3995
MD, PhD (Medicine), scientific researcher at the Clinical Department of infectious pathology
俄罗斯联邦, MoscowRamazan Alakaev
Institute of Dentistry and Maxillofacial Surgery of Kh.M. Berbekov Kabardino-Balkarian State University
Email: kerimyshka77@gmail.com
ORCID iD: 0009-0003-5517-6484
5th-year student
俄罗斯联邦, NalchikEvgeniya Vyzhlova
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Healthcare of Russia
Email: Evizhlova@yandex.ru
ORCID iD: 0000-0003-3054-8694
PhD (Biology), researcher at the Laboratory of ontogenesis and correction of the interferon system
俄罗斯联邦, MoscowGalina Bragina
National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Healthcare of Russia
Email: bragina56@yandex.ru
ORCID iD: 0000-0003-4216-5631
researcher at the Laboratory of ontogenesis and correction of the interferon system
俄罗斯联邦, MoscowOleg Kalyuzhin
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Email: kalyuzhin@list.ru
ORCID iD: 0000-0003-3628-2436
MD, Dr. Sci. (Medicine), professor, professor of the Department of clinical immunology and allergology
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