PROBLEM OF EFFICIENCY AND SAFETY OF TREATMENT OF PATIENTS WITH LOW BACK PAIN


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Musculoskeletal pain syndromes, such as low back pain, are very common in the population, and are associated with significant periods of temporary disability and enormous material costs. Effective treatment of such conditions are often fraught with the risk of undesirable side effects. The possibility of use in the treatment of such patients the drug Nolodatak (flupirtine), which has analgesic, muscle relaxant and neuroprotective effects is analyzed. There are also analyzed indications for its intended purpose, the possible risks of the therapy and how to prevent them. Existing data allow us to examine flupirtine as an effective drug for the treatment of patients with musculoskeletal pain syndromes, particularly lower back pain. The exact adherence to the instructions for use of the drug, the correct assessment of the clinical picture of the disease, including the presence of concomitant somatic diseases, able to ensure the safety of the treatment process.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Pavel Kamchatnov

N.I. Pirogov Russian National Medical Research University

Email: pavkam7@gmail.com

Maya Magomedova

Izberbash Central District Hospital

Aleksandr Chugunov

N.I. Pirogov Russian National Medical Research University

Әдебиет тізімі

  1. Есин Р.Г., Лотфуллина Н.З., Есин О.Р. Цервикалгия, дорзалгия, люмбалгия. Дифференциальная диагностика, дифференцированная терапия. ИИЦ УД Президента РТ. Казань, 2015
  2. Камчатнов П.Р., Батышева Т.Т., Ганжула П.А., Гапонова О.В., Журавлева Е.Ю., Исмаилов A.M., Костенко Е.В., Бойко А.Н. Применение катадолона у больных со спондилогенной дорсопатией. Журнал неврологии и психиатрии им. С.С. Корсакова. 2006;106(11):46-9
  3. Brown D., Passmore G. Neural KCNQ (Kv7) channels. Br. J. Pharmacol. 2009;156(8):1185-95.
  4. Douros A., Bronder E., Andersohn F., Klimpel A., Thomae M., Sarganas G., Kreutz R., Garbe E. Drug-induced liver injury: results from the hospital-based Berlin Case-Control Surveillance Study. Br. J. Clin. Pharmacol. 2015;79(6):988-99.
  5. Fleckenstein J., Sittl R., Averbeck B., Lang P.M., Irnich D., Carr R.W. Activation of axonal Kv7 channels in human peripheral nerve by flupirtine but not placebo - therapeutic potential for peripheral neuropathies: results of a randomised controlled trial. J. Transl. Med. 2013;11:34-9.
  6. Klawe C., Maschke M. Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound. Expert Opin. Pharmacother. 2009;10(9):1495-500.
  7. Kornhuber J., Bleich S., Wiltfang J., Maler M., Parsons C.G. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2* block via activation of voltage independent potassium channels. J. Neural. Transm. 1999;106(9-10):857-67.
  8. Mueller-Schwefe G. Flupirtine in acute and chronic pain associated with muscle tenseness. Results of a postmarket surveillance study. Fortschr. Med. Orig. 2003;121(1):11-18.
  9. Szelenyi I., Nickel B., Borbe H.O., Brune H. Mode of antinociceptive action on flupirtine in the rats. Br. J. Pharmacol. 1989;97:835-42.
  10. Uberall M.A., Mueller-Schwefe G.H., Terhaag B. Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double-blind, placebo- and active-controlled parallel-group phase IV study. Curr. Med. Res. Opin. 2012;28(10):1617-34.
  11. Wörz R., Stroehmann I. Ruckemschmerzen: Leitlinien der medicamentosen therapie. Munch. Med. Wschr. 2000:142; 27-33.
  12. Wörz R. Long-term-treatment of chronic pain patients with flupirtine on hepatotoxicity and persistent effectiveness from 7 months to 22 years. MMW Fortschr. Med. 2014;156(Suppl 4):127-34.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

© Bionika Media, 2016

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>