On the pharmacological interactions of antibiotics magnesium and on the magnesium deficiency ar as a result of antibiotic treatment


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

There are antagonistic interaction between magnesium ions and certain antibiotics (especially aminoglycosides and fluoroquinolones). Firstly, antibiotics cause severe loss of magnesium that necessitates administration of magnesium preparations. Secondly, magnesium ions reduce the effectiveness of fluoroquinolones and aminoglycosides due to chelation. Therefore, separate intake of antibiotics and of magnesium preparations has to be stipulated in order to increase the efficiency and the safety of antibiotic therapy.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Olga Gromova

Ivanovo state medical academy

Email: unesco.gromova@gmail.com
MD, professor of the Department of pharmacology and clinical pharmacology

Ivan Torshin

Moscow institute of physics and technology (state university)

candidate of physico-mathematical sciences, associate professor of the Department of intelligent systems

Valentin Moiseev

Peoples' Friendsh ip University of Russia

academician of RAS, MD, professor, head of the Department of therapy

Maria Sorokina

Peoples' Friendship University of Russia

intern of the Department of therapy

Әдебиет тізімі

  1. June C.H., Thompson C.B., Kennedy M.S., Nims J., Thomas E.D. Profound hypomagnesemia and renal magnesium wasting associated with the use of cyclosporine for marrow transplantation. Transplantation. 1985;39(6):620-4.
  2. Quamme G.A. Renal handling of magnesium: drug and hormone interactions. Magnesium. 1986;5(5-6):248-72.
  3. Zumkley H., Losse H., Spieker C., Zidek W. Effects of drugs on magnesium requirements. Magnesium. 1987;6(1):12-7.
  4. Campo S., Breda E., Di Girolamo M. Hypomagnesaemia on antibiotic therapy. Postgrad. Med. J. 1988;64(750):336-7.
  5. Xie Y., Yang L. Calcium and Magnesium Ions Are Membrane-Active against Stationary-Phase Staphylococcus aureus with High Specificity. Sci. Rep. 2016;6:20628.
  6. Li Y., Liu G., Zhai Z., Liu L., Li H., Yang K., Tan L., Wan P., Liu X., Ouyang Z., Yu Z., Tang T., Zhu Z., Qu X., Dai K. Antibacterial properties of magnesium in vitro and in an in vivo model of implant-associated methicillin-resistant Staphylococcus aureus infection. Antimicrob. Agents Chemother. 2014;58(12):7586-91.
  7. D'amato R.F., Thornsberry C., Baker C.N., Kirven L.A. Effect of calcium and magnesium ions on the susceptibility of Pseudomonas species to tetracycline, gentamicin polymyxin B, and carbenicillin. Antimicrob. Agents Chemother. 1975;7(5):596-600.
  8. Lecomte S., Baron M.H., Chenon M.T., Coupry C., Moreau N.J. Effect of magnesium complexation by fluoroquinolones on their antibacterial properties. Antimicrob. Agents Chemother. 1994;38(12):2810-6.
  9. Jaehde U., Sorgel F., Stephan U., Schunack W. Effect of an antacid containing magnesium and aluminum on absorption, metabolism, and mechanism of renal elimination of pefloxacin in humans. Antimicrob. Agents Chemother. 1994;38(5):1129-33.
  10. Wade R.L., Chaudhari P., Natoli J.L., Taylor R.J., Nathanson B.H., Horn D.L. Nephrotoxicity and other adverse events among inpatients receiving liposomal amphotericin B or amphotericin B lipid complex. Diagn. Microbiol. Infect. Dis. 2013;76(3):361-7.
  11. Abo-Salem E., Fowler J.C., Attari M., Cox C.D., Perez-Verdia A., Panikkath R., Nugent K. Antibiotic-induced cardiac arrhythmias. Cardiovasc. Ther. 2014;32(1):19-25.
  12. Cervin A., Wallwork B. Efficacy and safety of long-term antibiotics (macrolides) for the treatment of chronic rhinosinusitis. Curr. Allergy Asthma Rep. 2014;14(3):416.
  13. Ayad R.F., Assar M.D., Simpson L., Garner J.B., Schussler J.M. Causes and management of drug-induced long QT syndrome. Proc. (Bayl. Univ. Med. Cent.). 2010;23(3):250-5.
  14. Kawamura Y. Drugs affecting serum magnesium concentration. Clin. Calcium. 2012;22(8):1211-6.
  15. Zaloga G.P., Chernow B., Pock A., Wood B., Zaritsky A., Zucker A. Hypomagnesemia is a common complication of aminoglycoside therapy. Surg. Gynecol. Obstet. 1984;158(6):561-5.
  16. Garland H.O., Birdsey T.J., Davidge C.G., McLaughlin J.T., Oakes L.M., Smith A.J, Harpur E.S. Effects of gentamicin, neomycin and tobramycin on renal calcium and magnesium handling in two rat strains. Clin. Exp. Pharmacol. Physiol. 1994;21(2):109-15.
  17. Kes P., Reiner Z. Symptomatic hypomagnesemia associated with gentamicin therapy. Magnes Trace Elem. 1990;9(1):54-60.
  18. Rankin L.I., Krous H., Fryer A.W., Whang R. Enhancement of gentamicin nephrotoxicity by magnesium depletion in the rat. Miner. Electrolyte Metab. 1984;10(3):199-203.
  19. Wong N.L., Magil A.B., Dirks J.H. Effect of magnesium diet in gentamicin-induced acute renal failure in rats. Nephron. 1989;51(1):84-8.
  20. Nanji A.A., Denegri J.F. Hypomagnesemia associated with gentamicin therapy. Drug Intell. Clin. Pharm. 1984;18(7-8):596-8.
  21. von Vigier R.O., Truttmann A.C., Zindler-Schmocker K., Bettinelli A., Aebischer C.C., Wermuth B., Bianchetti M.G. Aminoglycosides and renal magnesium homeostasis in humans. Nephrol. Dial. Transplant. 2000;15(6):822-6.
  22. Barton C.H., Pahl M., Vaziri N.D., Cesario T. Renal magnesium wasting associated with amphotericin B therapy. Am. J. Med. 1984;77131:471-4.
  23. Elliott C., Newman N., Madan A. Gentamicin effects on urinary electrolyte excretion in healthy subjects. Clin. Pharmacol. Ther. 2000;67111:16-21.
  24. Cunningham J.J., Anbar R.D., Crawford J.D. Hypomagnesemia: a multifactorial complication of treatment of patients with severe burn trauma. JPEN J. Parenter. Enteral. Nutr. 1987;11(4):364-7.
  25. Lee C.T., Chen H.C., Ng H.Y., Lai L.W., Lien Y.H. Renal adaptation to gentamicin-induced mineral loss. Am. J. Nephrol. 2012;35(3):279-86.
  26. Kushner J.M., Peckman H.J., Snyder C.R. Seizures associated with fluoroquinolones. Ann. Pharmacother. 2001;35(10):1194-8.
  27. Stahlmann R., Lode H. Safety considerations of fluoroquinolones in the elderly: an update. Drugs Aging. 2010;27(3):193-209.
  28. Shakibaei M., de Souza P., van Sickle D., Stahlmann R. Biochemical changes in Achilles tendon from juvenile dogs after treatment with ciprofloxacin or feeding a magnesium-deficient diet. Arch. Toxicol. 2001;75(6):369-74.
  29. Торшин И.Ю., Громова О.А. Молекулярные механизмы магния и дисплазии соединительной ткани. РМЖ. 2008;4:263-9. [Torshin I. Yu., Gromova O. A. Molecular mechanisms of magnesium and connective tissue dysplasia. Russian medical journal. 2008;4:263-9 (in Russ.)]
  30. Egerbacher M., Wolfesberger B., Walter I., Seirberl G. Integrins mediate the effects of quinolones and magnesium deficiency on cultured rat chondrocytes. Eur. J. Cell. Biol. 1999;78(6):391-7.
  31. Forster C., Schwabe R., Lozo E., Zippel U., Vormann J., Gunther T., Merker H.J., Stahlmann R. Quinolone-induced arthropathy: exposure of magnesium-deficient aged rats or immature rats, mineral concentrations in target tissues and pharmacokinetics. Arch. Toxicol. 1997;72(1):26-32.
  32. Forster C., Rucker M., Shakibaei M., Baumann-Wilschke I., Vormann J., Stahlmann R. Effects of fluoroquinolones and magnesium deficiency in murine limb bud cultures. Arch. Toxicol. 1998;72(7):411-9.
  33. Shakibaei M., Kociok K., Forster C., Vormann J., Gunther T., Stahlmann R., Merker H.J. Comparative evaluation of ultrastructural changes in articular cartilage of ofloxacin-treated and magnesium-deficient immature rats. Toxicol. Pathol. 1996;24(5):580-7.
  34. Forster C., Kociok K., Shakibaei M., Merker H.J., Vormann J., Gunther T., Stahlmann R. Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats. Arch. Toxicol. 1996;70(5):261-70.
  35. Громова О.А., Калачева А.Г., Торшин И.Ю. и др. Недостаточность магния - достоверный фактор риска коморбидных состояний: результаты крупномасштабного скрининга магниевого статуса в регионах России. Фарматека. 2013;6:116-29. [Gromova O.A., Kalacheva A.G., Torshin I.Yu. et al. Deficiency of magnesium - a significant risk factor of comorbid conditions: results of a large-scale screening of magnesium status in the regions of Russia. Pharmateca. 2013;6:116-29 (in Russ.)]

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML

© Bionika Media, 2017

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>