Peculiarities of the course of rheumatoid arthritis in patients with thrombocytosis and comorbid conditions

Мұқаба

Дәйексөз келтіру

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Аннотация

Rheumatoid arthritis (RA) is a disease with a wide comorbid background, with the most common and socially significant being cardiovascular disease, which is the main cause of mortality.

Aim: to estimate and compare comorbidity profile in groups of RA patients with and without thrombocytosis.

Material and methods. The study enrolled 240 patients with RA, of whom 120 patients with normal thrombocytosis and 120 with thrombocytosis. Laboratory tests included assessment of the levels of RF, ACPA, ESR, CRP, ferritin, TPO, IL-6, soluble P-selectin. RA activity was determined by DAS28, instrumental examination consisted in determination of radiological stage of hand and foot lesions according to Steinbroecker, besides, the frequency of comorbid pathology was evaluated.

Results. The levels of ESR, CRP, IL-6, TPO-ferritin, RF and median values of DAS28 activity by ESR and CRP were significantly higher in subjects with RA and thrombocytosis compared to patients with normal level of platelets. There were also differences in the incidence of radiological stages I and III. In turn, in patients with thrombocytosis, the incidence of some comorbidities was significantly higher.

Conclusion. RA patients with thrombocytosis have higher clinical and laboratory activity as well as radiological progression of the disease in comparison with RA patients without thrombocytosis. These peculiarities of the course of RA require more intensive treatment. Besides, wide range of comorbid pathology is more frequent in the group of RA patients with thrombocytosis and this fact should be taken into consideration in real clinical practice.

Толық мәтін

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Авторлар туралы

Vadim Mazurov

I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatology Hospital No. 25

Хат алмасуға жауапты Автор.
Email: maz.nwgmu@yandex.ru
ORCID iD: 0000-0002-0797-2051

MD, professor, academician of RAS, Chief scientific consultant, director, head of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, head of the Center for autoimmune diseases, Honored Worker of Science of the Russian Federation

Ресей, Saint Petersburg; 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya Str.

Evgeny Melnikov

I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatology Hospital No. 25

Email: melnikovzhenya@mail.ru
ORCID iD: 0000-0002-8521-6542

postgraduate student at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald, rheumatologist

Ресей, Saint Petersburg; 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya Str.

Kira Morozova

Clinical Rheumatology Hospital No. 25

Email: kiramorozoba@mail.ru
ORCID iD: 0000-0002-4113-3104

rheumatologist

Ресей, 190068, Saint Petersburg, 30 Bol`shaya Pod`yacheskaya Str.

Victoria Evgrafova

Inlab Genetics LLC

Email: Tinakonan@mail.ru
ORCID iD: 0000-0002-7050-6838

laboratory assistant

Ресей, 192019, Saint Petersburg, 37 Sedova Str.

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