Febuxostat: efficacy and safety of the drug, prospects for application (literature review)

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Дәйексөз келтіру

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Аннотация

Prevalence of hyperuricemia and gout is increasing worldwide, which also leads to growing expenses for the sphere of healthcare. The clinical significance of gout becomes even more significant due to its close association with cardiovascular and metabolic diseases. In this regard, the search for rational remedies for gout pharmacotherapy is quite actual. Current literature review highlights the aspect of main clinical studies of xanthine oxidase inhibitor febuxostat, with an emphasis on points of cardiovascular safety and nephroprotection. A conclusion was made concerning the efficacy and safety of the drug in gout treatment, and also about the presence, along with urate-lowering effect, of other potentially valuable pharmacotherapeutic properties. Febuxostat is the medicine of choice in patients with reduced renal function who are ineffective or poorly tolerated by allopurinol. The pleiotropic effects identified in febuxostat open up prospects for its use in various fields of medicine. That requires further research work.

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Авторлар туралы

Elena Shchemeleva

I.I. Dzhanelidze Saint Petersburg Research Institute

Хат алмасуға жауапты Автор.
Email: schemeleva@yandex.ru
ORCID iD: 0000-0003-3566-6761

MD, PhD (Medicine), researcher at the Department of emergency cardiology and rheumatology

Ресей, 192242, Saint Petersburg, 3 Budapeshtskaya St.

Elena Skorodumova

I.I. Dzhanelidze Saint Petersburg Research Institute

Email: elskor@mail.ru
ORCID iD: 0000-0002-5017-0214

MD, Dr. Sci. (Medicine), leading researcher at the Department of emergency cardiology and rheumatology

Ресей, 192242, Saint Petersburg, 3 Budapeshtskaya St.

Әдебиет тізімі

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