Life quality in comorbid patients with atrial fibrillation and non-alcoholic fatty liver disease having hyperammoniemia

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Life quality of patients (LQ) is a key parameter of treatment efficacy. The influence of comorbid conditions at LQ has been repeatedly proven by many studies. However, in patients with atrial fibrillation (AF) in combination with non-alcoholic fatty liver disease (NAFLD) and hyperammonemia (HA), a comprehensive assessment of LQ has not been performed.

The aim: to estimate LQ in comorbid patients with AF and NAFLD with HA.

Material and methods. The study included 103 individuals: 40 healthy persons (15 females, 25 males, aged 58.24 ± 9.21 years) and 63 patients with permanent or persistent AF and NAFLD (25 females, 38 males, aged 63.92 ± 10.11 years). Among the study participants with AF in combination with NAFLD and HA, 2 randomized groups were identified: group 1 (n = 39) – patients who received standard therapy (angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, antiarrhythmic, diuretic, anticoagulant drugs); group 2 (n = 24) – patients who received L-ornithine-L-aspartate in addition to standard therapy. Validated SF-36 Health Status Survey (SF-36) questionnaire was used to assess LQ.

Results. It was reliably established that AF and NAFLD patients with GA have significantly lower LQ indexes comparatively to healthy individuals (p < 0.001). In patients with AF, NAFLD and HA, in the course of additional therapy by L-ornithine-L-aspartate, a significant improvement in LQ indexes was recorded comparatively to patients receiving standard therapy (p < 0.05).

Conclusion. Obtained data confirm the negative impact of AF in combination with NAFLD and HA at the LQ of patients. The addition of the hypoammonemic drug L-ornithine-L-aspartate to standard therapy demonstrated an advantage over standard treatment in this category of patients in the form of improved LQ indexes.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Sergey Alekseenko

Far Eastern State Medical University of the Ministry of Healthcare of Russia

Email: sa.alexeenko@gmail.com
ORCID iD: 0000-0003-1724-9980
SPIN-код: 9298-1764

MD, Dr. Sci.(Medicine), professor, head of the Department of hospital therapy

Ресей, Khabarovsk

Anastasia Pan

Far Eastern State Medical University of the Ministry of Healthcare of Russia

Хат алмасуға жауапты Автор.
Email: gjpbbnbdd@mail.ru
ORCID iD: 0009-0006-1606-5919
SPIN-код: 5314-2260

MD, assistant at the Department of hospital therapy

Ресей, Khabarovsk

Irina Zaikova-Khelimskaya

Far Eastern State Medical University of the Ministry of Healthcare of Russia

Email: irinavh@mail.ru
ORCID iD: 0000-0002-7517-4027
SPIN-код: 7311-3389

MD, Dr. Sci. (Medicine), professor of the Department of hospital therapy

Ресей, Khabarovsk

Әдебиет тізімі

  1. Потемина Т.Е., Кузнецова С.В., Перешеин А.В., Самойлова О.Ю., Янушанец О.И. Качество жизни в здравоохранении: критерии, цели, перспективы. Российский остеопатический журнал. 2018;(3–4):98–106. [Potemina TE, Kuznetsova SV, Pereshein AV, Samoilova OYu, Yanushanets OI. Quality of life in healthcare services: Criteria, goals, prospects. Rossiiskiy osteopaticheskiy zhurnal = Russian Osteopathic Journal. 2018;(3–4):98–106 (In Russ.)]. EDN: YSGAKT. https://doi.org/10.32885/2220-0975-2018-3-4-98-106
  2. Van Gelder IC, Rienstra M, Bunting KV, Casado-Arroyo R, Caso V, Crijns HJGM et al.; ESC Scientific Document Group. 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2024;45(36):3314–3414. PMID: 39210723. https://doi.org/10.1093/eurheartj/ehae176
  3. Пан А.А., Зайкова-Хелимская И.В., Алексеенко С.А. Клиническое значение и возможности коррекции гипераммониемии у больных с фибрилляцией предсердий. Бюллетень физиологии и патологии дыхания. 2024;(92):85−92. [Pan AА, Zaikova-Khelimskaya IV, Alekseenko SA. Clinical significance and possibilities for correction of hyperammonemia in patients with atrial fibrillation. Byulleten’ fiziologii i patologii dyhaniya = Bulletin of Physiology and Pathology of Respiration. 2024;(92):85−92 (In Russ.)]. EDN: BTTOAS. https://doi.org/10.36604/1998-5029-2024-92-85-92
  4. Алиева Л.Х., Резник Е.В. Гипераммониемия у пациентов с хронической сердечной недостаточностью. Терапия. 2024;10(S6):50. [Alieva LKh, Reznik EV. Hyperammonemia in patients with chronic heart failure. Terapiya = Therapy. 2024;10(S6):50 (In Russ.)]. EDN: EJNHPF. https://dx.doi.org/10.18565/therapy.2024.8suppl.1-393
  5. Алиева Л.Х., Ильясова Щ.М., Азизова Х.Ш., Резник Е.В. Тревога и депрессия у пациентов с сердечной недостаточностью. Терапия. 2024;10(S6):49. [Alieva LKh, Ilyasova ShM, Azizova KhSh, Reznik EV. Anxiety and depression in patients with heart failure. Terapiya = Therapy. 2024;10(S6):49 (In Russ.)]. EDN: YJJRLU. https://dx.doi.org/10.18565/therapy.2024.8suppl.1-393
  6. Жидяевский А.Г., Галяутдинов Г.С., Галеева Ш.Ш. Влияние фибрилляции предсердий на качество жизни пациентов с хронической сердечной недостаточностью. Терапия. 2024;10(S6):137. [Zhidyaevsky AG, Galyautdinov GS, Galeeva ShSh. The impact of atrial fibrillation on the quality of life of patients with chronic heart failure. Terapiya = Therapy. 2024;10(S6):137 (In Russ.)]. EDN: OLHQMW. https://dx.doi.org/10.18565/therapy.2024.8suppl.1-393
  7. Галеева Ш.Ш., Галяутдинов Г.С., Жидяевский А.Г. Анализ уровня психосоциальной адаптации пациентов с ишемической болезнью сердца и фибрилляцией предсердий к хронической сердечной недостаточности. Терапия. 2024;10(S6):105. [Galeeva ShSh, Galyautdinov GS, Zhidyaevsky AG. Analysis of the level of psychosocial adaptation of patients with coronary heart disease and atrial fibrillation to chronic heart failure. Terapiya = Therapy. 2024;10(S6):105 (In Russ.)]. EDN: QAVNNC. https://dx.doi.org/10.18565/therapy.2024.8suppl.1-393
  8. Rush KL, Seaton CL, Burton L, Loewen P, O’Connor BP, Moroz L et al. Quality of life among patients with atrial fibrillation: A theoretically-guided cross-sectional study. PLoS One. 2023;18(10):e0291575. PMID: 37797044. PMCID: PMC10553272. https://doi.org/10.1371/journal.pone.0291575
  9. Taylor EC, O’Neill M, Hughes LD, Moss-Morris R. Atrial fibrillation, quality of life and distress: A cluster analysis of cognitive and behavioural responses. Qual Life Res. 2022;31(5):1415–25. PMID: 34618326. PMCID: PMC9023425. https://doi.org/10.1007/s11136-021-03006-w
  10. Senoo K, Yukawa A, Ohkura T, Iwakoshi H, Nishimura T, Teramukai S et al. Depression and quality of life in older adults with atrial fibrillation: A cross-sectional community-based study. Geriatr Gerontol Int. 2022;22(7):505–10. PMID: 35614017. https://doi.org/10.1111/ggi.14397
  11. Germanova O, Koonts L, Reshetnikova Yu, Sheifer M, Bikbaeva K, Kuvshinova N et al. Quality of life evaluation in patients with paroxysmal atrial fibrillation. Psychiatr Danub. 2024;36(Suppl 2):303–7. PMID: 39378487.
  12. Де В.А., Батюкина С.В., Кочетков А.И., Клепикова М.В., Коник В.А., Остроумова О.Д. Когнитивный статус пациентов с ишемической болезнью сердца и сопутствующей фибрилляцией предсердий. Фарматека. 2024;31(4):40–47. [De VA, Batyukina SV, Kochetkov AI, Klepikova MV, Konik VA, Ostroumova OD. Cognitive status of patients with coronary artery disease and concomitant atrial fibrillation. Farmateka. 2024;31(4):40–47 (In Russ.)]. EDN: CTMYFU. https://dx.doi.org/10.18565/pharmateca.2024.4.40-47
  13. Орлова И.Ю., Батюкина С.В., Кочетков А.И., Пиксина Г.Ф., Плотникова Н.А., Остроумова О.Д. Состояние когнитивных функций у пациентов с различными формами фибрилляции предсердий. Фарматека. 2024;31(1):78–84. [Orlova IYu, Batyukina SV, Kochetkov AI, Piksina GF, Plotnikova NA, Ostroumova OD. State of cognitive functions in patients with various forms of atrial fibrillation. Farmateka. 2024;31(1):78–84 (In Russ.)]. EDN: GEJAKW. https://dx.doi.org/10.18565/pharmateca.2024.1.78-84
  14. Ивашкин В.Т., Драпкина О.М., Маевская М.В., Райхельсон К.Л., Оковитый С.В., Жаркова М.С. с соавт. Клинические рекомендации Российского общества по изучению печени, Российской гастроэнтерологической ассоциации, Российского общества профилактики неинфекционных заболеваний, Российской ассоциации эндокринологов, Российского научного медицинского общества терапевтов, Национального общества профилактической кардиологии, Российской ассоциации геронтологов и гериатров по неалкогольной жировой болезни печени. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2025;35(1):94–152. [Ivashkin VT, Drapkina OM, Maevskaya MV, Raikhelson KL, Okovityi SV, Zharkova MS et al. Clinical Guidelines of the Russian Society for the Study of the Liver, Russian Gastroenterological Association, Russian Society for the Prevention of Non-Communicable Diseases, Russian Association of Endocrinologists, Russian Scientific Medical Society of Therapists, National Society of Preventive Cardiology, Russian Association of Gerontologists and Geriatricians on Non-Alcoholic Fatty Liver Disease. Rossiiskiy zhurnal gastroenterologii, gepatologii, koloproktologii = Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2025;35(1):94–152 (In Russ.)]. EDN: HLXIGH. https://doi.org/10.22416/1382-4376-2025-35-1-94-152
  15. Инструкция по обработке данных, полученных с помощью опросника SF-36. Доступ: https://therapy.irkutsk.ru/doc/sf36a.pdf (дата обращения – 29.05.2025). [Instructions for processing data obtained using the SF-36 questionnaire. URL: https://therapy.irkutsk.ru/doc/sf36a.pdf (date of access – 29.05.2025) (In Russ.)].
  16. Лазебник Л.Б., Туркина С.В., Ермолова Т.В., Тарасова Л.В., Плотникова Е.Ю., Мязин Р.Г. с соавт. Гипераммониемия у взрослых – 2025. Практические рекомендации. Экспериментальная и клиническая гастроэнтерология. 2024;(12):167–189. [Lazebnik LB, Turkina SV, Ermolova TV, Tarasova LV, Plotnikova EYu, Myazin RG et al. Hyperammonemia in adults – 2025. Practical recommendations. Eksperimental’naya i klinicheskaya gastroenterologiya = Experimental and Clinical Gastroenterology. 2024;(12):167–189 (In Russ.)]. EDN: ITDGVX. https://doi.org/10.31146/1682-8658-ecg-232-12-167-189

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