Study of macrophage infiltration of various organs’ tissues in case of COVID-19 coronavirus infection

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Resumo

Studies of the presence of macrophages in various organs and tissues in COVID-19 are fragmented and mainly limited to the study of the lungs. The aim of the study was to determine the presence of macrophage infiltration in various organs and tissues in patients with COVID-19. Material and methods. A complex pathoanatomical study of sectional material obtained after autopsies of 23 deceased patients with the main diagnosis of COVID-19 was carried out. Results. Multiple aberrant aggregations of obese CD68 positive macrophages were found, with lesions predominantly observed in the parenchyma of the lungs and kidneys. Conclusion. CD68-positive macrophages were detected in all organs studied in COVID-19 patients, with different intensity and localization of infiltration, which may indicate a single mechanism of pathogenesis in lesions of various organs in patients with this disease.

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Sobre autores

Dmitry Vishnyakov

Bashkir State Medical University of the Ministry of Healthcare of Russia

Email: nomadsoul84@gmail.com
assistant of the Department of pathological anatomy

Ildar Kabirov

Bashkir State Medical University of the Ministry of Healthcare of Russia

Email: ildarkabirov@gmail.ru
PhD in Medicine, acting vice-rector for innovative work and digital transformation, associate professor of the Department of urology with the course of FVE

Kadriya Enikeeva

Bashkir State Medical University of the Ministry of Healthcare of Russia

Email: kalya1996@mail.ru
assistant of the Department of pharmacology with a course of clinical pharmacology

Liliya Kalimullina

Bashkir State Medical University of the Ministry of Healthcare of Russia

Email: lilia.kalim@mail.ru
junior researcher at central scientific research laboratory

Lidiya Sadretdinova

Bashkir State Medical University of the Ministry of Healthcare of Russia

Email: shuraleyka1@mail.ru
assistant at the Department of internal medicine

Anton Tyurin

Bashkir State Medical University of the Ministry of Healthcare of Russia

Email: anton.bgmu@gmail.com
PhD in Medicine, professor, head of the Department of internal diseases

Valentin Pavlov

Bashkir State Medical University of the Ministry of Healthcare of Russia

Email: pavlov@bashgmu.ru
Dr. med. habil., professor, academician of the Russian Academy of Sciences, head of the Department of urology with the course of FVE

Julia Kzhyskowska

University of Heidelberg; National Research Tomsk State University

Email: julia.kzhyshkowska@medma.uni-heidelberg.de
Doctor of Biological Sciences, professor, head of the Department of innate immunity and immunological tolerance, Institute of immunology and transfusion medicine, Faculty of Medicine, Mannheim; head of the laboratory of translational cellular and molecular biomedicine

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