Some aspects of pathogenesis and prevention of sudden cardiac death in patients with chronic obstructive pulmonary disease


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Resumo

Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of sudden cardiac death (SCD), especially in patients with frequent exacerbations for 5 years after diagnosis. The article provides an overview of the problem of SCD in patients with COPD. Into the risk group of developing SCD we include patients with COPD with a previous pathology of the cardiovascular system (myocardial infarction, hypertension, arrhythmias), patients with severe COPD, who have phenotypes "frequent exacerbations" of respiratory disease. One of the main reasons that may underlie the development of sudden death, is the development of cardiac arrhythmias that most often recorded in patients with COPD undergoing extensive myocardial infarction. The pathogenesis of arrhythmias in patients with COPD is multifactorial. Detection of comorbidity in patients with COPD will allow to take into account their individual characteristics when choosing pharmacotherapy. COPD patients with a high risk of SCD is necessary to limit the frequent use of bronchodilators, in particular short-acting methylxanthines, drugs that can prolong the interval QT (for example, 14-membered macrolides).

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Sobre autores

Nina Karoli

V.I. Razumovsky Saratov State Medical University

MD, Professor of Department of Hospital Therapy

Andrey Rebrov

V.I. Razumovsky Saratov State Medical University

Email: andreyrebrov@yandex.ru
MD, professor, Head of Department of Hospital Therapy

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