Dynamics of morphofunctional indexes of microcirculatory bloodstream in a patient who have suffered from COVID-19


Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Acesso é pago ou somente para assinantes

Resumo

In the pathogenesis of COVID-19, a significant role is assigned to microcirculation disorders. A number of works performed by various methods in vivo have shown similar disorders in patients with a new coronavirus infection at various stages of the disease. However, there have been no studies on the non-invasive research of microcirculation parameters in patients before the beginning of new coronavirus infection and at the stage of resolution of polysegmental pneumonia associated with COVID-19. In the represented clinical case, using bulbar microscopy, we revealed a significant declination of microcirculation indexes in a patient with pneumonia associated with COVID-19, at the resolution stage, compared with the initial data before the start of the disease, which suggests the influence of COVID-19 at the morphofunctional parameters of the microcirculatory bloodstream. The obtained data are consistent with the concept of the role of microcirculation disorders caused by endothelial damage in COVID-19 pathogenesis.

Texto integral

Acesso é fechado

Sobre autores

T. Kheilo

LLC «Center for Therapeutic Ophthalmology» (LLC «CTO»)

Email: cto96@mail.ru
117218, Moscow, 18/2 Krzhizhanovskogo Str. Tel.: +7 (985) 769-73-50

E. Gladysheva

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: еglad8@mail.ru
129090, Moscow, 3/1 Bolshaya Sukharevskaya Sq. Tel.: +7 (903) 670-69-81

Yu. Danilogorskaya

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: julia_dan@mail.ru
129090, Moscow, 3/1 Bolshaya Sukharevskaya Sq. Tel.: +7 (903) 670-69-81

M. Dzhavatkhanova

I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)

Email: mmm-2200@mail.ru
129090, Moscow, 3/1 Bolshaya Sukharevskaya Sq. Tel.: +7 (903) 670-69-81

Bibliografia

  1. Quinaglia T., Shabani M., Breder I. et al. Coronavirus disease-19: The multi-level, multi-faceted vasculopathy. Atherosclerosis. 2021; 322: 39-50. doi: 10.1016/j.atherosclerosis.2021.02.009.
  2. Varga Z., Flammer A.J., Steiger P. et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020; 395(10234): 1417-18. doi: 10.1016/S0140-6736(20)30937-5.
  3. Mondal R., Lahiri D., Deb S. et al. COVID-19: Are we dealing with a multisystem vasculopathy in disguise of a viral infection? J Thromb Thrombolysis. 2020; 50(3): 567-79. doi: 10.1007/s11239-020-02210-8.
  4. Tibirica E., De Lorenzo A. Importance of the evaluation of systemic microvascular flow and reactivity in critically ill patients with coronavirus disease 2019 - COVID-19. Microvasc Res. 2020; 131: 104028. doi: 10.1016/j. mvr.2020.104028.
  5. Gupta A., Madhavan M.V., Sehgal K. et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020; 26(7): 1017-32. doi: 10.1038/ s41591-020-0968-3.
  6. Huertas A., Montani D., Savale L. et al. Endothelial cell dysfunction: A major player in SARS-CoV-2 infection (COVID-19)? Eur Respir J. 2020; 56(1): 2001634. doi: 10.1183/13993003.01634-2020.
  7. Bikdeli B., Madhavan M.V., Jimenez D. et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, antithrombotic therapy, and follow-up: JACC state-of-the-art review. J Am Coll Cardiol. 2020; 75(23): 2950-73. doi: 10.1016/j. jacc.2020.04.031.
  8. Levi M., Thachil J., Iba T., Levy J.H. Coagulation abnormalities and thrombosis in patients with COVID-19. Lancet Haematol. 2020; 7(6): e438-e440. doi: 10.1016/S2352-3026(20)30145-9.
  9. Martini R. The compelling arguments for the need of microvascular investigation in COVID-19 critical patients. Clin Hemorheol Microcirc. 2020; 75(1): 27-34. doi: 10.3233/CH200895.
  10. Петрищев Н.Н., Халепо О.В., Вавиленкова Ю.А., Власов Т.Д. COVID-19 и сосудистые нарушения (обзор литературы). Регионарное кровообращение и микроциркуляция. 2020; 3: 90-98. @@Petrishchev N.N., Khalepo O. V., Vavilenkova Yu.A., Vlasov T.D. COVID-19 and vascular disorders (literature review). Regionarnoe krovoobrashcheniye i mikrotsirkulyatsiya = Regional hemodynamics and microcirculation. 2020; 3:90-98 (In Russ.). doi: https://doi.org/10.24884/1682-6655-2020-19-3-90-98.
  11. Kanoore Edul V.S., Caminos Eguillor J.F., Ferrara G. et al. Microcirculation alterations in severe COVID-19 pneumonia. J Crit Care. 2021; 61: 73-75. doi: 10.1016/j.jcrc.2020.10.002.
  12. Damiani E., Carsetti A., Casarotta E. et al. Microvascular alterations in patients with SARS-CoV-2 severe pneumonia. Ann Intensive Care. 2020; 10(1): 60. doi: 10.1186/s13613-020-00680-w.
  13. Глазкова П.А., Куликов Д.А., Рогаткин Д.А. с соавт. Неинвазивная оценка кожной микроциркуляции крови у пациентов с COVID-19. Три клинических наблюдения. Альманах клинической медицины. 2020; 48: 27-31. @@Glazkova P.A., Kulikov D.A., Rogatkin D.A. et al. Non-invasive assessment of skin microcirculation in patients with COVID-19: three clinical cases. Al'manakh klinicheskoy meditsiny = Almanac of Clinical Medicine. 2020; 48: 27-31 (In Russ.). doi: https://doi.org/10.18786/2072-0505-2020-48-037.
  14. Jung E.M., Stroszczynski C., Jung F. Contrast enhanced ultrasonography (CEUS) to detect abdominal microcirculatory disorders in severe cases of COVID-19 infection: First experience. Clin Hemorheol Microcirc. 2020; 74(4): 353-61. doi: 10.3233/CH-209003.
  15. Natalello G., De Luca G., Gigante L. et al. Nailfold capillaroscopy findings in patients with coronavirus disease 2019: Broadening the spectrum of COVID-19 microvascular involvement. Microvasc Res. 2021; 133: 104071. doi: 10.1016/j.mvr.2020.104071. www.rnmot.ru
  16. Козлов В.И. Капилляроскопия в клинической практике. М.: Практическая медицина. 2015; 232 с. @@Kozlov V.I. Capillaroscopy in clinical practice. Moscow: Prakticheskaya mediczina = Practical Medicine., 2015; 232pp. (In Russ.). ISBN: 978-5-98811-342-3.
  17. Hernandez A., Vinals M., Pablos A. et al. Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study. Int Immunopharmacol. 2021; 90: 107261. doi: 10.1016/j.intimp.2020.107261.
  18. Shah M., Captain J., Vaidya V. et al. Safety and efficacy of ozone therapy in mild to moderate COVID-19 patients: A phase 1/11 randomized control trial (SEOT study). Int Immunopharmacol. 2021; 91: 107301. doi: 10.1016/j.intimp.2020.107301.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML

Declaração de direitos autorais © Bionika Media, 2021

Este site utiliza cookies

Ao continuar usando nosso site, você concorda com o procedimento de cookies que mantêm o site funcionando normalmente.

Informação sobre cookies