Dependence of cognitive profile of multimorbid elderly patients with hypertension from charlson comorbidity index
- Autores: Ostroumova O.D.1,2, Dzamikhov K.K.1, Kochetkov A.I.1, Ostroumova T.M.2, Shastina V.R.3, Lyakhova M.A.3
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Afiliações:
- Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
- I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
- Hospital for War Veterans No. 2 of the Department of Healthcare of Moscow
- Edição: Volume 10, Nº 5 (2024)
- Páginas: 22-30
- Seção: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/635059
- DOI: https://doi.org/10.18565/therapy.2024.5.22-30
- ID: 635059
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Resumo
Population aging entails an increased incidence of age-associated diseases that are risk factors for cognitive impairment.
The aim: to еvaluate cognitive function (CF) of multimorbid patients aged ≥ 60 years with arterial hypertension (AH) depending on the Charlson comorbidity index.
Material and methods. Study participants (n = 330) were divided into 3 groups depending on the Charlson index: group 1 – 0–4 points (n = 69, median age 72 years), group 2 – 5–7 points (n = 182, median age 80 years), group 3 – ≥ 8 points (n = 79, median age 82 years). All patients were assessed for QF using a range of cognitive tests.
Results. The Montreal Cognitive Assessment Scale (MoCA) revealed statistically significant differences between groups 1 and 2, 1 and 3 (p = 0.032 and p < 0.001, respectively; maximum in group 1, minimum in group 3), on the Mini-Mental State Examination (MMSE) – between groups 1 and 3 (27 and 26 points respectively, p = 0.014), on the Alzheimer’s Disease Assessment Scale – Cognitive subscale (ADAS-Cog) – between groups 1 and 2 (12 and 15 points respectively, p = 0.011). Group 3 patients scored statistically significantly lower on the Boston Test compared to groups 1 and 2 (p₁₋₂₋₃ = 0.008). In the literal association’s subtest, group 3 patients named statistically significantly fewer words compared to patients in groups 1 and 2 (p = 0.002 and p = 0.006, respectively). In the Digit Symbol Substitution Test, statistically significant differences were recorded between groups 1 and 3 (p = 0.022). Statistically significant differences between the groups (p₁₋₂₋₃ < 0.001) were also found when evaluating the results of the maximum digit series memorization test.
Conclusion. The obtained results indicate a direct influence of the number of certain comorbidities and age of patients, which reflects the Charlson comorbidity index, on the severity of cognitive impairment in polymorbid elderly and senile patients with AH.
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Sobre autores
Olga Ostroumova
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Autor responsável pela correspondência
Email: ostroumova.olga@mail.ru
ORCID ID: 0000-0002-0795-8225
Código SPIN: 3910-6585
MD, Dr. Sci. (Medicine), professor, head of the Department of therapy and multimorbid pathology named after academician M.S. Vovsi, professor of the Department of clinical pharmacology and propaedeutics of internal diseases
Rússia, 125993, Moscow, 2/1 build. 1 Barrikadnaya St.; 119048, Moscow, 8 build. 2 Trubetskaya St.Kantemir Dzamikhov
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
Email: kantemir.dk@mail.ru
ORCID ID: 0000-0002-8941-7018
Código SPIN: 9603-5881
MD, postgraduate student of the Department of therapy and multimorbid pathology named after academician M.S. Vovsi
Rússia, 125993, Moscow, 2/1 build. 1 Barrikadnaya St.Alexey Kochetkov
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia
Email: ak_info@list.ru
ORCID ID: 0000-0001-5801-3742
Código SPIN: 9212-6010
MD, PhD (Medicine), associate professor, associate professor of the Department of therapy and multimorbid pathology named after academician M.S. Vovsi
Rússia, 125993, Moscow, 2/1 build. 1 Barrikadnaya St.Tatyana Ostroumova
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Email: t.ostroumova3@gmail.com
ORCID ID: 0000-0003-1499-247X
MD, PhD (Medicine), assistant at the Department of nervous diseases and neurosurgery
Rússia, 119048, Moscow, 8 build. 2 Trubetskaya St.Vera Shastina
Hospital for War Veterans No. 2 of the Department of Healthcare of Moscow
Email: ShastinaVR@zdrav.mos.ru
ORCID ID: 0000-0002-2933-7876
Código SPIN: 7230-9602
MD, PhD (Medicine), chief physician of Hospital for War Veterans No. 2 of the Department of Healthcare of Moscow
Rússia, 109472, Moscow, 168 Volgogradsky AvenueMarina Lyakhova
Hospital for War Veterans No. 2 of the Department of Healthcare of Moscow
Email: ShastinaVR@zdrav.mos.ru
MD, head of the Department of palliative care
Rússia, 109472, Moscow, 168 Volgogradsky AvenueBibliografia
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